ZNF25

 

Full name: zinc finger protein 25 Alias Symbol: KOX19|FLJ31890|Zfp9
Type: protein-coding gene Cytoband: 10p11.21
Entrez ID: 219749 HGNC ID: HGNC:13043 Ensembl Gene: ENSG00000175395 OMIM ID: 194528
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZNF25:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZNF25 219749 228185_at -0.5968 0.3468
GSE26886 ZNF25 219749 228185_at 0.4622 0.1655
GSE45670 ZNF25 219749 235164_at -0.7716 0.0002
GSE53622 ZNF25 219749 33836 -0.2145 0.0441
GSE53624 ZNF25 219749 33836 -0.2532 0.0069
GSE63941 ZNF25 219749 228185_at -3.0779 0.0000
GSE77861 ZNF25 219749 235164_at -0.0160 0.9357
GSE97050 ZNF25 219749 A_24_P69691 -0.3458 0.2769
SRP007169 ZNF25 219749 RNAseq -0.3744 0.3469
SRP008496 ZNF25 219749 RNAseq 0.4968 0.1996
SRP064894 ZNF25 219749 RNAseq -0.1316 0.6234
SRP133303 ZNF25 219749 RNAseq -0.1297 0.5415
SRP159526 ZNF25 219749 RNAseq -0.4687 0.0154
SRP193095 ZNF25 219749 RNAseq 0.0672 0.5946
SRP219564 ZNF25 219749 RNAseq -0.0017 0.9972
TCGA ZNF25 219749 RNAseq -0.3645 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  


 

Survival by ZNF25 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of ZNF25:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZNF25 219749 2 6 22
GSE20123 ZNF25 219749 2 5 23
GSE43470 ZNF25 219749 2 3 38
GSE46452 ZNF25 219749 0 13 46
GSE47630 ZNF25 219749 5 11 24
GSE54993 ZNF25 219749 9 0 61
GSE54994 ZNF25 219749 3 9 41
GSE60625 ZNF25 219749 0 0 11
GSE74703 ZNF25 219749 1 1 34
GSE74704 ZNF25 219749 0 4 16
TCGA ZNF25 219749 14 22 60

Total number of gains: 38; Total number of losses: 74; Total Number of normals: 376.  


 

Somatic mutations of ZNF25:

 

Generating mutation plots.

 

Highly correlated genes for ZNF25:

 

Showing top 20/1094 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZNF25AFF30.89418303
ZNF25FIBIN0.852726404
ZNF25MAGI10.813293303
ZNF25PEG30.807942404
ZNF25RAB230.797262303
ZNF25CTR90.795446303
ZNF25CRLS10.78824303
ZNF25SLC37A30.780154303
ZNF25LRRN4CL0.775739606
ZNF25TBX50.774078606
ZNF25ANGPT10.766216606
ZNF25NPY1R0.766089303
ZNF25ZMAT30.765319303
ZNF25ZNF2250.764893404
ZNF25MAGI2-AS30.76337505
ZNF25RCN20.762211404
ZNF25AGTR10.761887606
ZNF25MBD50.759473303
ZNF25MYOCD0.759136505
ZNF25RCN10.75646303

For details and further investigation, click here