| Full name: angiotensin II receptor type 1 | Alias Symbol: AT1|AT2R1|AGTR1A|AT2R1A|HAT1R|AG2S|AT2R1B|AT1B | ||
| Type: protein-coding gene | Cytoband: 3q24 | ||
| Entrez ID: 185 | HGNC ID: HGNC:336 | Ensembl Gene: ENSG00000144891 | OMIM ID: 106165 |
| Drug and gene relationship at DGIdb | |||
AGTR1 involved pathways:
Expression of AGTR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGTR1 | 185 | 205357_s_at | -2.0797 | 0.0821 | |
| GSE20347 | AGTR1 | 185 | 205357_s_at | -0.0750 | 0.5988 | |
| GSE23400 | AGTR1 | 185 | 205357_s_at | -0.1837 | 0.0346 | |
| GSE26886 | AGTR1 | 185 | 205357_s_at | -0.0163 | 0.9328 | |
| GSE29001 | AGTR1 | 185 | 205357_s_at | -0.3715 | 0.2273 | |
| GSE38129 | AGTR1 | 185 | 205357_s_at | -0.8429 | 0.0154 | |
| GSE45670 | AGTR1 | 185 | 205357_s_at | -2.8276 | 0.0000 | |
| GSE53622 | AGTR1 | 185 | 37465 | -1.1839 | 0.0000 | |
| GSE53624 | AGTR1 | 185 | 37465 | -0.8840 | 0.0000 | |
| GSE63941 | AGTR1 | 185 | 205357_s_at | -3.9549 | 0.0000 | |
| GSE77861 | AGTR1 | 185 | 208016_s_at | -0.0670 | 0.4711 | |
| GSE97050 | AGTR1 | 185 | A_23_P166616 | -0.3726 | 0.1711 | |
| SRP133303 | AGTR1 | 185 | RNAseq | -0.2538 | 0.6330 | |
| SRP219564 | AGTR1 | 185 | RNAseq | -1.0189 | 0.2850 | |
| TCGA | AGTR1 | 185 | RNAseq | -1.2567 | 0.0032 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by AGTR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AGTR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGTR1 | 185 | 22 | 0 | 8 | |
| GSE20123 | AGTR1 | 185 | 22 | 0 | 8 | |
| GSE43470 | AGTR1 | 185 | 23 | 0 | 20 | |
| GSE46452 | AGTR1 | 185 | 17 | 2 | 40 | |
| GSE47630 | AGTR1 | 185 | 19 | 3 | 18 | |
| GSE54993 | AGTR1 | 185 | 1 | 10 | 59 | |
| GSE54994 | AGTR1 | 185 | 35 | 1 | 17 | |
| GSE60625 | AGTR1 | 185 | 0 | 6 | 5 | |
| GSE74703 | AGTR1 | 185 | 20 | 0 | 16 | |
| GSE74704 | AGTR1 | 185 | 15 | 0 | 5 | |
| TCGA | AGTR1 | 185 | 70 | 1 | 25 |
Total number of gains: 244; Total number of losses: 23; Total Number of normals: 221.
Somatic mutations of AGTR1:
Generating mutation plots.
Highly correlated genes for AGTR1:
Showing top 20/1322 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGTR1 | NEGR1 | 0.854883 | 6 | 0 | 6 |
| AGTR1 | LAMA2 | 0.82704 | 7 | 0 | 7 |
| AGTR1 | MGARP | 0.814179 | 3 | 0 | 3 |
| AGTR1 | MRGPRF | 0.811367 | 7 | 0 | 7 |
| AGTR1 | PRICKLE2 | 0.806863 | 6 | 0 | 6 |
| AGTR1 | MYOCD | 0.798245 | 6 | 0 | 6 |
| AGTR1 | RASSF3 | 0.796622 | 4 | 0 | 4 |
| AGTR1 | OLFML1 | 0.789337 | 9 | 0 | 9 |
| AGTR1 | SGCD | 0.788889 | 8 | 0 | 7 |
| AGTR1 | MRVI1 | 0.786942 | 7 | 0 | 7 |
| AGTR1 | SVEP1 | 0.785934 | 8 | 0 | 8 |
| AGTR1 | UBXN10 | 0.784626 | 3 | 0 | 3 |
| AGTR1 | CILP | 0.783128 | 9 | 0 | 9 |
| AGTR1 | STARD9 | 0.782151 | 5 | 0 | 5 |
| AGTR1 | DIXDC1 | 0.775099 | 10 | 0 | 10 |
| AGTR1 | SYNC | 0.77397 | 7 | 0 | 7 |
| AGTR1 | ADAMTS5 | 0.770452 | 10 | 0 | 9 |
| AGTR1 | TNFSF12 | 0.769042 | 3 | 0 | 3 |
| AGTR1 | CNRIP1 | 0.767393 | 8 | 0 | 7 |
| AGTR1 | OPTN | 0.766416 | 3 | 0 | 3 |
For details and further investigation, click here
