| Full name: cardiolipin synthase 1 | Alias Symbol: dJ967N21.6|CLS1|GCD10 | ||
| Type: protein-coding gene | Cytoband: 20p12.3 | ||
| Entrez ID: 54675 | HGNC ID: HGNC:16148 | Ensembl Gene: ENSG00000088766 | OMIM ID: 608188 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CRLS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRLS1 | 54675 | 223978_s_at | 0.2992 | 0.5080 | |
| GSE26886 | CRLS1 | 54675 | 225324_at | 0.6303 | 0.0202 | |
| GSE45670 | CRLS1 | 54675 | 223978_s_at | 0.1990 | 0.2723 | |
| GSE53622 | CRLS1 | 54675 | 564 | 0.3186 | 0.0001 | |
| GSE53624 | CRLS1 | 54675 | 564 | 0.5732 | 0.0000 | |
| GSE63941 | CRLS1 | 54675 | 223978_s_at | 0.2364 | 0.6458 | |
| GSE77861 | CRLS1 | 54675 | 223978_s_at | 0.0495 | 0.8530 | |
| GSE97050 | CRLS1 | 54675 | A_33_P3502315 | 0.2508 | 0.4794 | |
| SRP007169 | CRLS1 | 54675 | RNAseq | 0.3650 | 0.4777 | |
| SRP008496 | CRLS1 | 54675 | RNAseq | 0.7469 | 0.0265 | |
| SRP064894 | CRLS1 | 54675 | RNAseq | 0.4228 | 0.0069 | |
| SRP133303 | CRLS1 | 54675 | RNAseq | 0.4203 | 0.0005 | |
| SRP159526 | CRLS1 | 54675 | RNAseq | 0.4070 | 0.0993 | |
| SRP193095 | CRLS1 | 54675 | RNAseq | -0.2373 | 0.1929 | |
| SRP219564 | CRLS1 | 54675 | RNAseq | 0.7205 | 0.0454 | |
| TCGA | CRLS1 | 54675 | RNAseq | -0.2198 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CRLS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRLS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRLS1 | 54675 | 11 | 2 | 17 | |
| GSE20123 | CRLS1 | 54675 | 11 | 2 | 17 | |
| GSE43470 | CRLS1 | 54675 | 12 | 1 | 30 | |
| GSE46452 | CRLS1 | 54675 | 26 | 1 | 32 | |
| GSE47630 | CRLS1 | 54675 | 18 | 4 | 18 | |
| GSE54993 | CRLS1 | 54675 | 1 | 14 | 55 | |
| GSE54994 | CRLS1 | 54675 | 25 | 2 | 26 | |
| GSE60625 | CRLS1 | 54675 | 0 | 0 | 11 | |
| GSE74703 | CRLS1 | 54675 | 9 | 1 | 26 | |
| GSE74704 | CRLS1 | 54675 | 5 | 1 | 14 | |
| TCGA | CRLS1 | 54675 | 40 | 11 | 45 |
Total number of gains: 158; Total number of losses: 39; Total Number of normals: 291.
Somatic mutations of CRLS1:
Generating mutation plots.
Highly correlated genes for CRLS1:
Showing top 20/535 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRLS1 | NSMCE4A | 0.797054 | 3 | 0 | 3 |
| CRLS1 | NAP1L1 | 0.796125 | 3 | 0 | 3 |
| CRLS1 | ZBTB44 | 0.793964 | 3 | 0 | 3 |
| CRLS1 | ZNF25 | 0.78824 | 3 | 0 | 3 |
| CRLS1 | ANAPC4 | 0.771572 | 3 | 0 | 3 |
| CRLS1 | GNS | 0.761704 | 3 | 0 | 3 |
| CRLS1 | DNAJC9 | 0.754936 | 3 | 0 | 3 |
| CRLS1 | AASDHPPT | 0.751126 | 3 | 0 | 3 |
| CRLS1 | ANGEL2 | 0.748067 | 3 | 0 | 3 |
| CRLS1 | MCMBP | 0.743048 | 4 | 0 | 4 |
| CRLS1 | HMG20A | 0.742394 | 3 | 0 | 3 |
| CRLS1 | WDR61 | 0.73385 | 3 | 0 | 3 |
| CRLS1 | FBXO21 | 0.732597 | 3 | 0 | 3 |
| CRLS1 | KLHL15 | 0.731937 | 3 | 0 | 3 |
| CRLS1 | CCDC82 | 0.729482 | 3 | 0 | 3 |
| CRLS1 | PTPN11 | 0.727834 | 3 | 0 | 3 |
| CRLS1 | DHX15 | 0.725935 | 3 | 0 | 3 |
| CRLS1 | PPP2R1B | 0.72468 | 3 | 0 | 3 |
| CRLS1 | ASXL2 | 0.723429 | 3 | 0 | 3 |
| CRLS1 | ELP2 | 0.722311 | 4 | 0 | 4 |
For details and further investigation, click here
