| Full name: angiopoietin 1 | Alias Symbol: KIAA0003|Ang1 | ||
| Type: protein-coding gene | Cytoband: 8q23.1 | ||
| Entrez ID: 284 | HGNC ID: HGNC:484 | Ensembl Gene: ENSG00000154188 | OMIM ID: 601667 |
| Drug and gene relationship at DGIdb | |||
ANGPT1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway | |
| hsa04066 | HIF-1 signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway |
Expression of ANGPT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANGPT1 | 284 | 205608_s_at | -0.4619 | 0.7464 | |
| GSE20347 | ANGPT1 | 284 | 205608_s_at | -0.0181 | 0.9006 | |
| GSE23400 | ANGPT1 | 284 | 205608_s_at | -0.2115 | 0.0045 | |
| GSE26886 | ANGPT1 | 284 | 205608_s_at | 0.1926 | 0.6181 | |
| GSE29001 | ANGPT1 | 284 | 205609_at | -0.0511 | 0.8974 | |
| GSE38129 | ANGPT1 | 284 | 205608_s_at | -0.6102 | 0.0547 | |
| GSE45670 | ANGPT1 | 284 | 205609_at | -1.6631 | 0.0007 | |
| GSE53622 | ANGPT1 | 284 | 8376 | -0.6122 | 0.0005 | |
| GSE53624 | ANGPT1 | 284 | 8376 | -0.1295 | 0.5084 | |
| GSE63941 | ANGPT1 | 284 | 205608_s_at | -4.1628 | 0.0003 | |
| GSE77861 | ANGPT1 | 284 | 205608_s_at | -0.0798 | 0.5271 | |
| GSE97050 | ANGPT1 | 284 | A_23_P216023 | -0.9000 | 0.1531 | |
| SRP007169 | ANGPT1 | 284 | RNAseq | 1.7450 | 0.0068 | |
| SRP008496 | ANGPT1 | 284 | RNAseq | 1.7993 | 0.0006 | |
| SRP064894 | ANGPT1 | 284 | RNAseq | 0.6095 | 0.1725 | |
| SRP133303 | ANGPT1 | 284 | RNAseq | 0.0559 | 0.8904 | |
| SRP159526 | ANGPT1 | 284 | RNAseq | 0.2828 | 0.4965 | |
| SRP193095 | ANGPT1 | 284 | RNAseq | 0.6836 | 0.0161 | |
| SRP219564 | ANGPT1 | 284 | RNAseq | 0.0987 | 0.9283 | |
| TCGA | ANGPT1 | 284 | RNAseq | -0.2757 | 0.2067 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by ANGPT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANGPT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANGPT1 | 284 | 16 | 0 | 14 | |
| GSE20123 | ANGPT1 | 284 | 17 | 0 | 13 | |
| GSE43470 | ANGPT1 | 284 | 22 | 0 | 21 | |
| GSE46452 | ANGPT1 | 284 | 25 | 0 | 34 | |
| GSE47630 | ANGPT1 | 284 | 24 | 0 | 16 | |
| GSE54993 | ANGPT1 | 284 | 0 | 20 | 50 | |
| GSE54994 | ANGPT1 | 284 | 37 | 1 | 15 | |
| GSE60625 | ANGPT1 | 284 | 0 | 4 | 7 | |
| GSE74703 | ANGPT1 | 284 | 19 | 0 | 17 | |
| GSE74704 | ANGPT1 | 284 | 11 | 0 | 9 | |
| TCGA | ANGPT1 | 284 | 59 | 1 | 36 |
Total number of gains: 230; Total number of losses: 26; Total Number of normals: 232.
Somatic mutations of ANGPT1:
Generating mutation plots.
Highly correlated genes for ANGPT1:
Showing top 20/1075 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANGPT1 | MRGPRF | 0.802139 | 6 | 0 | 6 |
| ANGPT1 | C20orf194 | 0.79319 | 3 | 0 | 3 |
| ANGPT1 | LRCH2 | 0.774146 | 7 | 0 | 7 |
| ANGPT1 | FIBIN | 0.773685 | 4 | 0 | 4 |
| ANGPT1 | SPATA9 | 0.770413 | 3 | 0 | 3 |
| ANGPT1 | ZNF25 | 0.766216 | 6 | 0 | 6 |
| ANGPT1 | LRRN4CL | 0.765394 | 6 | 0 | 6 |
| ANGPT1 | ZFAND5 | 0.764193 | 3 | 0 | 3 |
| ANGPT1 | PGR | 0.761899 | 6 | 0 | 6 |
| ANGPT1 | PPP1R14A | 0.755821 | 4 | 0 | 4 |
| ANGPT1 | ZEB1 | 0.752984 | 3 | 0 | 3 |
| ANGPT1 | SMIM10 | 0.749888 | 5 | 0 | 5 |
| ANGPT1 | MYOCD | 0.748237 | 5 | 0 | 5 |
| ANGPT1 | CLIP3 | 0.747445 | 9 | 0 | 9 |
| ANGPT1 | LNP1 | 0.747232 | 3 | 0 | 3 |
| ANGPT1 | BHMT2 | 0.743048 | 9 | 0 | 9 |
| ANGPT1 | KLHL41 | 0.74126 | 3 | 0 | 3 |
| ANGPT1 | PYGM | 0.739332 | 7 | 0 | 7 |
| ANGPT1 | KANK2 | 0.738559 | 8 | 0 | 8 |
| ANGPT1 | CLMP | 0.738102 | 6 | 0 | 5 |
For details and further investigation, click here
