| Full name: T-box transcription factor 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q24.21 | ||
| Entrez ID: 6910 | HGNC ID: HGNC:11604 | Ensembl Gene: ENSG00000089225 | OMIM ID: 601620 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TBX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBX5 | 6910 | 240715_at | -0.7484 | 0.2752 | |
| GSE20347 | TBX5 | 6910 | 211886_s_at | 0.1391 | 0.1187 | |
| GSE23400 | TBX5 | 6910 | 211886_s_at | -0.1374 | 0.0010 | |
| GSE26886 | TBX5 | 6910 | 240715_at | 0.5745 | 0.0069 | |
| GSE29001 | TBX5 | 6910 | 211886_s_at | -0.1687 | 0.1539 | |
| GSE38129 | TBX5 | 6910 | 211886_s_at | -0.0193 | 0.8378 | |
| GSE45670 | TBX5 | 6910 | 240715_at | -1.6029 | 0.0000 | |
| GSE53622 | TBX5 | 6910 | 79521 | -0.5328 | 0.0249 | |
| GSE53624 | TBX5 | 6910 | 79521 | -0.4868 | 0.0022 | |
| GSE63941 | TBX5 | 6910 | 240715_at | -4.1961 | 0.0000 | |
| GSE77861 | TBX5 | 6910 | 211886_s_at | -0.0475 | 0.6571 | |
| GSE97050 | TBX5 | 6910 | A_23_P25176 | -1.4315 | 0.1200 | |
| SRP064894 | TBX5 | 6910 | RNAseq | -0.0091 | 0.9805 | |
| SRP133303 | TBX5 | 6910 | RNAseq | -0.0284 | 0.9503 | |
| SRP159526 | TBX5 | 6910 | RNAseq | 0.5759 | 0.4185 | |
| SRP219564 | TBX5 | 6910 | RNAseq | -0.0798 | 0.9312 | |
| TCGA | TBX5 | 6910 | RNAseq | 0.3689 | 0.2012 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by TBX5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBX5 | 6910 | 4 | 3 | 23 | |
| GSE20123 | TBX5 | 6910 | 4 | 3 | 23 | |
| GSE43470 | TBX5 | 6910 | 2 | 0 | 41 | |
| GSE46452 | TBX5 | 6910 | 9 | 1 | 49 | |
| GSE47630 | TBX5 | 6910 | 9 | 3 | 28 | |
| GSE54993 | TBX5 | 6910 | 0 | 5 | 65 | |
| GSE54994 | TBX5 | 6910 | 6 | 5 | 42 | |
| GSE60625 | TBX5 | 6910 | 0 | 0 | 11 | |
| GSE74703 | TBX5 | 6910 | 2 | 0 | 34 | |
| GSE74704 | TBX5 | 6910 | 2 | 2 | 16 | |
| TCGA | TBX5 | 6910 | 22 | 11 | 63 |
Total number of gains: 60; Total number of losses: 33; Total Number of normals: 395.
Somatic mutations of TBX5:
Generating mutation plots.
Highly correlated genes for TBX5:
Showing top 20/948 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBX5 | CNTN3 | 0.871942 | 3 | 0 | 3 |
| TBX5 | MGARP | 0.847028 | 3 | 0 | 3 |
| TBX5 | DCHS1 | 0.827092 | 5 | 0 | 5 |
| TBX5 | MSRB3 | 0.823976 | 6 | 0 | 6 |
| TBX5 | JAM3 | 0.82312 | 7 | 0 | 7 |
| TBX5 | ZCCHC24 | 0.816112 | 7 | 0 | 7 |
| TBX5 | SYNC | 0.814793 | 4 | 0 | 4 |
| TBX5 | MRGPRF | 0.811272 | 7 | 0 | 7 |
| TBX5 | DACT3 | 0.810993 | 6 | 0 | 6 |
| TBX5 | KANK2 | 0.803851 | 7 | 0 | 7 |
| TBX5 | DIXDC1 | 0.800288 | 6 | 0 | 6 |
| TBX5 | MAGI2-AS3 | 0.798499 | 6 | 0 | 6 |
| TBX5 | BNC2 | 0.79634 | 7 | 0 | 7 |
| TBX5 | LRRN4CL | 0.793912 | 7 | 0 | 7 |
| TBX5 | ITGA1 | 0.793147 | 7 | 0 | 6 |
| TBX5 | COX7A1 | 0.785474 | 7 | 0 | 7 |
| TBX5 | LINC01279 | 0.784092 | 4 | 0 | 4 |
| TBX5 | PDE5A | 0.781949 | 7 | 0 | 7 |
| TBX5 | ZEB1 | 0.780205 | 3 | 0 | 3 |
| TBX5 | C1QTNF7 | 0.779337 | 5 | 0 | 5 |
For details and further investigation, click here
