| Full name: apoptosis associated tyrosine kinase | Alias Symbol: AATYK|KIAA0641|LMTK1|LMR1|AATYK1|PPP1R77 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 9625 | HGNC ID: HGNC:21 | Ensembl Gene: ENSG00000181409 | OMIM ID: 605276 |
| Drug and gene relationship at DGIdb | |||
Expression of AATK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AATK | 9625 | 205986_at | 0.0913 | 0.7896 | |
| GSE20347 | AATK | 9625 | 205986_at | -0.0241 | 0.8461 | |
| GSE23400 | AATK | 9625 | 205986_at | -0.1041 | 0.0249 | |
| GSE26886 | AATK | 9625 | 205986_at | 0.4320 | 0.0021 | |
| GSE29001 | AATK | 9625 | 205986_at | -0.0312 | 0.8981 | |
| GSE38129 | AATK | 9625 | 205986_at | -0.2843 | 0.0141 | |
| GSE45670 | AATK | 9625 | 205986_at | -0.0774 | 0.4163 | |
| GSE53622 | AATK | 9625 | 47720 | -0.2821 | 0.0374 | |
| GSE53624 | AATK | 9625 | 47720 | 0.1276 | 0.1327 | |
| GSE63941 | AATK | 9625 | 205986_at | 0.9386 | 0.0001 | |
| GSE77861 | AATK | 9625 | 205986_at | 0.0238 | 0.9075 | |
| GSE97050 | AATK | 9625 | A_23_P10559 | -0.8169 | 0.1681 | |
| SRP064894 | AATK | 9625 | RNAseq | -0.0835 | 0.6518 | |
| SRP133303 | AATK | 9625 | RNAseq | -0.9677 | 0.0036 | |
| SRP159526 | AATK | 9625 | RNAseq | -0.0341 | 0.9253 | |
| SRP193095 | AATK | 9625 | RNAseq | 0.0115 | 0.9707 | |
| SRP219564 | AATK | 9625 | RNAseq | -0.1415 | 0.8348 | |
| TCGA | AATK | 9625 | RNAseq | -1.0090 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AATK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AATK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AATK | 9625 | 4 | 4 | 22 | |
| GSE20123 | AATK | 9625 | 4 | 4 | 22 | |
| GSE43470 | AATK | 9625 | 3 | 5 | 35 | |
| GSE46452 | AATK | 9625 | 34 | 0 | 25 | |
| GSE47630 | AATK | 9625 | 9 | 2 | 29 | |
| GSE54993 | AATK | 9625 | 2 | 5 | 63 | |
| GSE54994 | AATK | 9625 | 10 | 6 | 37 | |
| GSE60625 | AATK | 9625 | 6 | 0 | 5 | |
| GSE74703 | AATK | 9625 | 3 | 3 | 30 | |
| GSE74704 | AATK | 9625 | 4 | 3 | 13 | |
| TCGA | AATK | 9625 | 26 | 14 | 56 |
Total number of gains: 105; Total number of losses: 46; Total Number of normals: 337.
Somatic mutations of AATK:
Generating mutation plots.
Highly correlated genes for AATK:
Showing top 20/797 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AATK | EPN1 | 0.757124 | 4 | 0 | 4 |
| AATK | TMEM222 | 0.750692 | 3 | 0 | 3 |
| AATK | IL17F | 0.743128 | 3 | 0 | 3 |
| AATK | IFT122 | 0.722745 | 3 | 0 | 3 |
| AATK | CNTD2 | 0.714507 | 6 | 0 | 6 |
| AATK | LKAAEAR1 | 0.713342 | 3 | 0 | 3 |
| AATK | TTC9B | 0.709508 | 4 | 0 | 4 |
| AATK | ZSCAN10 | 0.705129 | 3 | 0 | 3 |
| AATK | TMEM145 | 0.702344 | 4 | 0 | 4 |
| AATK | MIER2 | 0.693053 | 4 | 0 | 3 |
| AATK | HRC | 0.692894 | 3 | 0 | 3 |
| AATK | TMEM102 | 0.692776 | 3 | 0 | 3 |
| AATK | SP8 | 0.691486 | 3 | 0 | 3 |
| AATK | TRAPPC1 | 0.685023 | 3 | 0 | 3 |
| AATK | NEUROD2 | 0.684788 | 3 | 0 | 3 |
| AATK | CNTN2 | 0.680148 | 6 | 0 | 5 |
| AATK | OR10J1 | 0.677898 | 3 | 0 | 3 |
| AATK | GSK3A | 0.677473 | 5 | 0 | 4 |
| AATK | FGF16 | 0.677211 | 6 | 0 | 6 |
| AATK | E2F4 | 0.676933 | 4 | 0 | 4 |
For details and further investigation, click here
