| Full name: 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) | Alias Symbol: PHACS|ACS | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 84680 | HGNC ID: HGNC:23989 | Ensembl Gene: ENSG00000110455 | OMIM ID: 608405 |
| Drug and gene relationship at DGIdb | |||
Expression of ACCS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACCS | 84680 | 228264_at | -0.6397 | 0.2909 | |
| GSE26886 | ACCS | 84680 | 228264_at | 0.4155 | 0.0798 | |
| GSE45670 | ACCS | 84680 | 228264_at | -0.3810 | 0.2037 | |
| GSE53622 | ACCS | 84680 | 62659 | -0.2936 | 0.0120 | |
| GSE53624 | ACCS | 84680 | 62659 | -0.3844 | 0.0001 | |
| GSE63941 | ACCS | 84680 | 228264_at | -0.1027 | 0.8734 | |
| GSE77861 | ACCS | 84680 | 228264_at | -0.0268 | 0.8213 | |
| GSE97050 | ACCS | 84680 | A_23_P24586 | -0.2531 | 0.2850 | |
| SRP007169 | ACCS | 84680 | RNAseq | -1.5411 | 0.0041 | |
| SRP064894 | ACCS | 84680 | RNAseq | 0.0336 | 0.9125 | |
| SRP133303 | ACCS | 84680 | RNAseq | -0.3371 | 0.2023 | |
| SRP159526 | ACCS | 84680 | RNAseq | -0.5210 | 0.1242 | |
| SRP193095 | ACCS | 84680 | RNAseq | 0.1645 | 0.5489 | |
| SRP219564 | ACCS | 84680 | RNAseq | -0.2459 | 0.5837 | |
| TCGA | ACCS | 84680 | RNAseq | -0.4203 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ACCS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACCS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACCS | 84680 | 2 | 7 | 21 | |
| GSE20123 | ACCS | 84680 | 2 | 6 | 22 | |
| GSE43470 | ACCS | 84680 | 3 | 4 | 36 | |
| GSE46452 | ACCS | 84680 | 8 | 5 | 46 | |
| GSE47630 | ACCS | 84680 | 3 | 9 | 28 | |
| GSE54993 | ACCS | 84680 | 3 | 0 | 67 | |
| GSE54994 | ACCS | 84680 | 3 | 9 | 41 | |
| GSE60625 | ACCS | 84680 | 0 | 0 | 11 | |
| GSE74703 | ACCS | 84680 | 2 | 2 | 32 | |
| GSE74704 | ACCS | 84680 | 2 | 5 | 13 | |
| TCGA | ACCS | 84680 | 15 | 20 | 61 |
Total number of gains: 43; Total number of losses: 67; Total Number of normals: 378.
Somatic mutations of ACCS:
Generating mutation plots.
Highly correlated genes for ACCS:
Showing all 16 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACCS | ERBB2 | 0.705108 | 3 | 0 | 3 |
| ACCS | SYTL5 | 0.623088 | 3 | 0 | 3 |
| ACCS | ZFYVE19 | 0.612006 | 3 | 0 | 3 |
| ACCS | RASSF6 | 0.592977 | 4 | 0 | 4 |
| ACCS | STX19 | 0.589495 | 3 | 0 | 3 |
| ACCS | RGS11 | 0.581179 | 3 | 0 | 3 |
| ACCS | ERCC5 | 0.58027 | 4 | 0 | 3 |
| ACCS | FOXB1 | 0.564808 | 3 | 0 | 3 |
| ACCS | TMEM217 | 0.562556 | 3 | 0 | 3 |
| ACCS | THAP7-AS1 | 0.557427 | 3 | 0 | 3 |
| ACCS | GARNL3 | 0.535844 | 4 | 0 | 3 |
| ACCS | SETDB2 | 0.532666 | 4 | 0 | 3 |
| ACCS | DDB2 | 0.531987 | 4 | 0 | 3 |
| ACCS | NISCH | 0.52261 | 4 | 0 | 3 |
| ACCS | WDR6 | 0.502513 | 5 | 0 | 3 |
| ACCS | D2HGDH | 0.501261 | 5 | 0 | 3 |
For details and further investigation, click here
