| Full name: damage specific DNA binding protein 2 | Alias Symbol: DDBB|UV-DDB2|FLJ34321|XPE | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 1643 | HGNC ID: HGNC:2718 | Ensembl Gene: ENSG00000134574 | OMIM ID: 600811 |
DDB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway |
Expression of DDB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDB2 | 1643 | 203409_at | -0.3176 | 0.2972 | |
| GSE20347 | DDB2 | 1643 | 203409_at | -0.3235 | 0.0504 | |
| GSE23400 | DDB2 | 1643 | 203409_at | -0.0037 | 0.9646 | |
| GSE26886 | DDB2 | 1643 | 203409_at | 0.1976 | 0.5001 | |
| GSE29001 | DDB2 | 1643 | 203409_at | -0.2905 | 0.3579 | |
| GSE38129 | DDB2 | 1643 | 203409_at | -0.1563 | 0.2626 | |
| GSE45670 | DDB2 | 1643 | 203409_at | -0.1789 | 0.3596 | |
| GSE53622 | DDB2 | 1643 | 99007 | -0.0560 | 0.6130 | |
| GSE53624 | DDB2 | 1643 | 47082 | -0.1090 | 0.1797 | |
| GSE63941 | DDB2 | 1643 | 203409_at | 0.7335 | 0.1550 | |
| GSE77861 | DDB2 | 1643 | 203409_at | -0.0337 | 0.9469 | |
| GSE97050 | DDB2 | 1643 | A_33_P3383955 | -0.1070 | 0.6270 | |
| SRP007169 | DDB2 | 1643 | RNAseq | -0.8433 | 0.0454 | |
| SRP008496 | DDB2 | 1643 | RNAseq | -0.8362 | 0.0020 | |
| SRP064894 | DDB2 | 1643 | RNAseq | 0.1093 | 0.5414 | |
| SRP133303 | DDB2 | 1643 | RNAseq | -0.3692 | 0.0292 | |
| SRP159526 | DDB2 | 1643 | RNAseq | -0.7428 | 0.0002 | |
| SRP193095 | DDB2 | 1643 | RNAseq | -0.4549 | 0.0035 | |
| SRP219564 | DDB2 | 1643 | RNAseq | -0.3329 | 0.3851 | |
| TCGA | DDB2 | 1643 | RNAseq | 0.3448 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DDB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDB2 | 1643 | 3 | 7 | 20 | |
| GSE20123 | DDB2 | 1643 | 3 | 6 | 21 | |
| GSE43470 | DDB2 | 1643 | 1 | 4 | 38 | |
| GSE46452 | DDB2 | 1643 | 8 | 5 | 46 | |
| GSE47630 | DDB2 | 1643 | 3 | 9 | 28 | |
| GSE54993 | DDB2 | 1643 | 3 | 0 | 67 | |
| GSE54994 | DDB2 | 1643 | 1 | 11 | 41 | |
| GSE60625 | DDB2 | 1643 | 0 | 0 | 11 | |
| GSE74703 | DDB2 | 1643 | 1 | 2 | 33 | |
| GSE74704 | DDB2 | 1643 | 2 | 4 | 14 | |
| TCGA | DDB2 | 1643 | 10 | 20 | 66 |
Total number of gains: 35; Total number of losses: 68; Total Number of normals: 385.
Somatic mutations of DDB2:
Generating mutation plots.
Highly correlated genes for DDB2:
Showing top 20/35 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDB2 | C19orf57 | 0.627381 | 3 | 0 | 3 |
| DDB2 | IL17RC | 0.614159 | 3 | 0 | 3 |
| DDB2 | SLC25A48 | 0.613307 | 4 | 0 | 3 |
| DDB2 | CES2 | 0.608905 | 4 | 0 | 3 |
| DDB2 | TMEM252 | 0.583996 | 3 | 0 | 3 |
| DDB2 | ALDH3A1 | 0.565051 | 6 | 0 | 4 |
| DDB2 | SOX6 | 0.559825 | 3 | 0 | 3 |
| DDB2 | GSDMC | 0.551141 | 3 | 0 | 3 |
| DDB2 | TGM5 | 0.546486 | 4 | 0 | 3 |
| DDB2 | CALML3 | 0.543025 | 7 | 0 | 4 |
| DDB2 | SVIL | 0.542678 | 5 | 0 | 3 |
| DDB2 | SOWAHC | 0.540303 | 4 | 0 | 3 |
| DDB2 | CBR3 | 0.533943 | 5 | 0 | 4 |
| DDB2 | THSD4 | 0.532393 | 4 | 0 | 3 |
| DDB2 | ACCS | 0.531987 | 4 | 0 | 3 |
| DDB2 | HRAS | 0.531919 | 7 | 0 | 3 |
| DDB2 | TRIM16 | 0.531288 | 6 | 0 | 3 |
| DDB2 | PIK3C2B | 0.529262 | 5 | 0 | 3 |
| DDB2 | SERPINB3 | 0.524343 | 5 | 0 | 4 |
| DDB2 | CYB5D2 | 0.524256 | 5 | 0 | 3 |
For details and further investigation, click here
