| Full name: SET domain bifurcated histone lysine methyltransferase 2 | Alias Symbol: CLLD8|CLLL8|KMT1F | ||
| Type: protein-coding gene | Cytoband: 13q14.2 | ||
| Entrez ID: 83852 | HGNC ID: HGNC:20263 | Ensembl Gene: ENSG00000136169 | OMIM ID: 607865 |
| Drug and gene relationship at DGIdb | |||
Expression of SETDB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SETDB2 | 83852 | 235339_at | -0.4702 | 0.1671 | |
| GSE26886 | SETDB2 | 83852 | 235338_s_at | 0.1481 | 0.5483 | |
| GSE45670 | SETDB2 | 83852 | 235339_at | -0.3249 | 0.0412 | |
| GSE53622 | SETDB2 | 83852 | 64069 | -0.2049 | 0.0000 | |
| GSE53624 | SETDB2 | 83852 | 64069 | -0.3318 | 0.0000 | |
| GSE63941 | SETDB2 | 83852 | 235339_at | -2.0850 | 0.0008 | |
| GSE77861 | SETDB2 | 83852 | 235339_at | -0.1183 | 0.3505 | |
| GSE97050 | SETDB2 | 83852 | A_23_P341532 | -0.1837 | 0.3364 | |
| SRP007169 | SETDB2 | 83852 | RNAseq | -0.4845 | 0.4085 | |
| SRP008496 | SETDB2 | 83852 | RNAseq | 0.2025 | 0.6391 | |
| SRP064894 | SETDB2 | 83852 | RNAseq | -0.0292 | 0.8727 | |
| SRP133303 | SETDB2 | 83852 | RNAseq | -0.4489 | 0.0043 | |
| SRP159526 | SETDB2 | 83852 | RNAseq | -0.6880 | 0.0386 | |
| SRP193095 | SETDB2 | 83852 | RNAseq | -0.6539 | 0.0000 | |
| SRP219564 | SETDB2 | 83852 | RNAseq | -0.4113 | 0.0598 | |
| TCGA | SETDB2 | 83852 | RNAseq | -0.3150 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SETDB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SETDB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SETDB2 | 83852 | 1 | 13 | 16 | |
| GSE20123 | SETDB2 | 83852 | 1 | 12 | 17 | |
| GSE43470 | SETDB2 | 83852 | 3 | 13 | 27 | |
| GSE46452 | SETDB2 | 83852 | 0 | 32 | 27 | |
| GSE47630 | SETDB2 | 83852 | 2 | 27 | 11 | |
| GSE54993 | SETDB2 | 83852 | 12 | 2 | 56 | |
| GSE54994 | SETDB2 | 83852 | 2 | 14 | 37 | |
| GSE60625 | SETDB2 | 83852 | 0 | 3 | 8 | |
| GSE74703 | SETDB2 | 83852 | 3 | 10 | 23 | |
| GSE74704 | SETDB2 | 83852 | 0 | 9 | 11 | |
| TCGA | SETDB2 | 83852 | 9 | 38 | 49 |
Total number of gains: 33; Total number of losses: 173; Total Number of normals: 282.
Somatic mutations of SETDB2:
Generating mutation plots.
Highly correlated genes for SETDB2:
Showing top 20/124 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SETDB2 | CADPS | 0.761757 | 3 | 0 | 3 |
| SETDB2 | ZADH2 | 0.76166 | 3 | 0 | 3 |
| SETDB2 | EMILIN1 | 0.750528 | 3 | 0 | 3 |
| SETDB2 | SCN3A | 0.750499 | 3 | 0 | 3 |
| SETDB2 | KATNAL2 | 0.736966 | 3 | 0 | 3 |
| SETDB2 | MAGEL2 | 0.731413 | 3 | 0 | 3 |
| SETDB2 | TBX3 | 0.730173 | 3 | 0 | 3 |
| SETDB2 | DEPTOR | 0.713847 | 3 | 0 | 3 |
| SETDB2 | ZFPM2 | 0.708789 | 3 | 0 | 3 |
| SETDB2 | CHST10 | 0.708584 | 3 | 0 | 3 |
| SETDB2 | GH1 | 0.705476 | 3 | 0 | 3 |
| SETDB2 | ZNF763 | 0.691909 | 5 | 0 | 4 |
| SETDB2 | ZC3H10 | 0.687142 | 4 | 0 | 4 |
| SETDB2 | FBXO38 | 0.681911 | 3 | 0 | 3 |
| SETDB2 | DMGDH | 0.67681 | 3 | 0 | 3 |
| SETDB2 | PNPLA7 | 0.669329 | 3 | 0 | 3 |
| SETDB2 | LRRC2 | 0.66513 | 4 | 0 | 3 |
| SETDB2 | ZCCHC18 | 0.661495 | 4 | 0 | 4 |
| SETDB2 | RNF180 | 0.65947 | 4 | 0 | 3 |
| SETDB2 | RXFP3 | 0.647651 | 3 | 0 | 3 |
For details and further investigation, click here
