| Full name: regulator of G protein signaling 11 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 8786 | HGNC ID: HGNC:9993 | Ensembl Gene: ENSG00000076344 | OMIM ID: 603895 |
| Drug and gene relationship at DGIdb | |||
Expression of RGS11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGS11 | 8786 | 211872_s_at | -0.6116 | 0.0925 | |
| GSE20347 | RGS11 | 8786 | 211872_s_at | -0.2623 | 0.0007 | |
| GSE23400 | RGS11 | 8786 | 211872_s_at | -0.2561 | 0.0000 | |
| GSE26886 | RGS11 | 8786 | 211872_s_at | 0.0616 | 0.7507 | |
| GSE29001 | RGS11 | 8786 | 211872_s_at | -0.1935 | 0.0242 | |
| GSE38129 | RGS11 | 8786 | 211872_s_at | -0.3012 | 0.0000 | |
| GSE45670 | RGS11 | 8786 | 211872_s_at | 0.0252 | 0.7878 | |
| GSE53622 | RGS11 | 8786 | 54299 | -1.0058 | 0.0000 | |
| GSE53624 | RGS11 | 8786 | 54299 | -1.3253 | 0.0000 | |
| GSE63941 | RGS11 | 8786 | 211872_s_at | 0.2283 | 0.1392 | |
| GSE77861 | RGS11 | 8786 | 211872_s_at | -0.2552 | 0.0387 | |
| GSE97050 | RGS11 | 8786 | A_23_P118122 | -0.4204 | 0.1540 | |
| SRP064894 | RGS11 | 8786 | RNAseq | -1.4639 | 0.0002 | |
| SRP133303 | RGS11 | 8786 | RNAseq | -2.3105 | 0.0000 | |
| SRP159526 | RGS11 | 8786 | RNAseq | -1.4182 | 0.0001 | |
| SRP193095 | RGS11 | 8786 | RNAseq | -1.2722 | 0.0008 | |
| SRP219564 | RGS11 | 8786 | RNAseq | -1.6426 | 0.0394 | |
| TCGA | RGS11 | 8786 | RNAseq | -1.6090 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by RGS11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGS11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGS11 | 8786 | 5 | 5 | 20 | |
| GSE20123 | RGS11 | 8786 | 5 | 4 | 21 | |
| GSE43470 | RGS11 | 8786 | 3 | 7 | 33 | |
| GSE46452 | RGS11 | 8786 | 38 | 1 | 20 | |
| GSE47630 | RGS11 | 8786 | 13 | 6 | 21 | |
| GSE54993 | RGS11 | 8786 | 3 | 5 | 62 | |
| GSE54994 | RGS11 | 8786 | 4 | 10 | 39 | |
| GSE60625 | RGS11 | 8786 | 4 | 0 | 7 | |
| GSE74703 | RGS11 | 8786 | 3 | 5 | 28 | |
| GSE74704 | RGS11 | 8786 | 3 | 2 | 15 | |
| TCGA | RGS11 | 8786 | 20 | 15 | 61 |
Total number of gains: 101; Total number of losses: 60; Total Number of normals: 327.
Somatic mutations of RGS11:
Generating mutation plots.
Highly correlated genes for RGS11:
Showing top 20/724 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGS11 | TCP11L2 | 0.734993 | 3 | 0 | 3 |
| RGS11 | MYZAP | 0.73254 | 3 | 0 | 3 |
| RGS11 | VMAC | 0.715038 | 3 | 0 | 3 |
| RGS11 | DEGS2 | 0.700776 | 4 | 0 | 3 |
| RGS11 | SH3BGRL2 | 0.699604 | 4 | 0 | 4 |
| RGS11 | GPX3 | 0.699231 | 8 | 0 | 8 |
| RGS11 | CGNL1 | 0.691177 | 4 | 0 | 4 |
| RGS11 | C4orf3 | 0.687259 | 4 | 0 | 3 |
| RGS11 | BHLHE23 | 0.671847 | 3 | 0 | 3 |
| RGS11 | MYL6 | 0.670196 | 3 | 0 | 3 |
| RGS11 | KMT2D | 0.66901 | 4 | 0 | 4 |
| RGS11 | JMJD1C | 0.665084 | 3 | 0 | 3 |
| RGS11 | PPP1R12C | 0.665077 | 4 | 0 | 3 |
| RGS11 | RAET1E | 0.66426 | 4 | 0 | 3 |
| RGS11 | ATP13A4 | 0.661084 | 4 | 0 | 3 |
| RGS11 | FAM3D | 0.660793 | 4 | 0 | 3 |
| RGS11 | CRISP3 | 0.660294 | 8 | 0 | 8 |
| RGS11 | LNX1 | 0.658574 | 4 | 0 | 4 |
| RGS11 | SHISA4 | 0.658133 | 3 | 0 | 3 |
| RGS11 | CAB39L | 0.656907 | 8 | 0 | 8 |
For details and further investigation, click here
