| Full name: ERCC excision repair 5, endonuclease | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q33.1 | ||
| Entrez ID: 2073 | HGNC ID: HGNC:3437 | Ensembl Gene: ENSG00000134899 | OMIM ID: 133530 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ERCC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERCC5 | 2073 | 202414_at | -0.4493 | 0.3915 | |
| GSE20347 | ERCC5 | 2073 | 202414_at | -0.5745 | 0.0001 | |
| GSE23400 | ERCC5 | 2073 | 202414_at | -0.1556 | 0.0136 | |
| GSE26886 | ERCC5 | 2073 | 202414_at | 0.0406 | 0.9030 | |
| GSE29001 | ERCC5 | 2073 | 202414_at | -0.4503 | 0.1565 | |
| GSE38129 | ERCC5 | 2073 | 202414_at | -0.5125 | 0.0000 | |
| GSE45670 | ERCC5 | 2073 | 202414_at | -0.3004 | 0.0647 | |
| GSE53622 | ERCC5 | 2073 | 55483 | -0.4678 | 0.0000 | |
| GSE53624 | ERCC5 | 2073 | 55483 | -0.4775 | 0.0000 | |
| GSE63941 | ERCC5 | 2073 | 202414_at | -0.8625 | 0.0627 | |
| GSE77861 | ERCC5 | 2073 | 202414_at | -0.5561 | 0.0081 | |
| GSE97050 | ERCC5 | 2073 | A_23_P117225 | 0.1198 | 0.6426 | |
| SRP007169 | ERCC5 | 2073 | RNAseq | 0.5318 | 0.5757 | |
| SRP064894 | ERCC5 | 2073 | RNAseq | -0.1131 | 0.4015 | |
| SRP133303 | ERCC5 | 2073 | RNAseq | -0.6058 | 0.0000 | |
| SRP159526 | ERCC5 | 2073 | RNAseq | -0.9715 | 0.0000 | |
| SRP193095 | ERCC5 | 2073 | RNAseq | -0.6781 | 0.0000 | |
| SRP219564 | ERCC5 | 2073 | RNAseq | -0.1338 | 0.7206 | |
| TCGA | ERCC5 | 2073 | RNAseq | -0.1460 | 0.0028 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ERCC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERCC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERCC5 | 2073 | 4 | 9 | 17 | |
| GSE20123 | ERCC5 | 2073 | 4 | 8 | 18 | |
| GSE43470 | ERCC5 | 2073 | 4 | 12 | 27 | |
| GSE46452 | ERCC5 | 2073 | 0 | 32 | 27 | |
| GSE47630 | ERCC5 | 2073 | 3 | 26 | 11 | |
| GSE54993 | ERCC5 | 2073 | 11 | 4 | 55 | |
| GSE54994 | ERCC5 | 2073 | 6 | 10 | 37 | |
| GSE60625 | ERCC5 | 2073 | 0 | 3 | 8 | |
| GSE74703 | ERCC5 | 2073 | 3 | 10 | 23 | |
| GSE74704 | ERCC5 | 2073 | 2 | 8 | 10 | |
| TCGA | ERCC5 | 2073 | 15 | 35 | 46 |
Total number of gains: 52; Total number of losses: 157; Total Number of normals: 279.
Somatic mutations of ERCC5:
Generating mutation plots.
Highly correlated genes for ERCC5:
Showing top 20/163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERCC5 | TNR | 0.720323 | 3 | 0 | 3 |
| ERCC5 | RWDD3 | 0.700685 | 3 | 0 | 3 |
| ERCC5 | BRSK1 | 0.695446 | 3 | 0 | 3 |
| ERCC5 | NAA16 | 0.694815 | 4 | 0 | 4 |
| ERCC5 | SUMF1 | 0.673415 | 4 | 0 | 3 |
| ERCC5 | TMEM37 | 0.672911 | 3 | 0 | 3 |
| ERCC5 | NSG1 | 0.671287 | 5 | 0 | 4 |
| ERCC5 | ICAM3 | 0.668843 | 4 | 0 | 3 |
| ERCC5 | CYB5D2 | 0.645985 | 3 | 0 | 3 |
| ERCC5 | PNPLA7 | 0.638095 | 4 | 0 | 4 |
| ERCC5 | PCCA | 0.634225 | 10 | 0 | 9 |
| ERCC5 | MYH14 | 0.628142 | 4 | 0 | 3 |
| ERCC5 | MAST4 | 0.627024 | 7 | 0 | 5 |
| ERCC5 | PPP2R2B | 0.624985 | 3 | 0 | 3 |
| ERCC5 | RASSF6 | 0.624461 | 4 | 0 | 3 |
| ERCC5 | SLC37A1 | 0.614351 | 7 | 0 | 5 |
| ERCC5 | MYO1C | 0.614015 | 4 | 0 | 3 |
| ERCC5 | YIPF1 | 0.612387 | 5 | 0 | 4 |
| ERCC5 | CUL4A | 0.608308 | 5 | 0 | 3 |
| ERCC5 | PIDD1 | 0.607612 | 5 | 0 | 3 |
For details and further investigation, click here
