| Full name: growth differentiation factor 5 | Alias Symbol: CDMP1|BMP14 | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 8200 | HGNC ID: HGNC:4220 | Ensembl Gene: ENSG00000125965 | OMIM ID: 601146 |
| Drug and gene relationship at DGIdb | |||
GDF5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04390 | Hippo signaling pathway |
Expression of GDF5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GDF5 | 8200 | 206614_at | 0.2923 | 0.6766 | |
| GSE20347 | GDF5 | 8200 | 206614_at | 0.0460 | 0.6620 | |
| GSE23400 | GDF5 | 8200 | 206614_at | -0.1024 | 0.0136 | |
| GSE26886 | GDF5 | 8200 | 206614_at | -0.0658 | 0.7276 | |
| GSE29001 | GDF5 | 8200 | 206614_at | -0.1798 | 0.4000 | |
| GSE38129 | GDF5 | 8200 | 206614_at | -0.0655 | 0.6273 | |
| GSE45670 | GDF5 | 8200 | 206614_at | 0.1654 | 0.0302 | |
| GSE63941 | GDF5 | 8200 | 206614_at | 0.0580 | 0.6634 | |
| GSE77861 | GDF5 | 8200 | 206614_at | -0.1035 | 0.3480 | |
| GSE97050 | GDF5 | 8200 | A_23_P259955 | 0.0647 | 0.9011 | |
| TCGA | GDF5 | 8200 | RNAseq | 1.4216 | 0.0173 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GDF5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GDF5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GDF5 | 8200 | 16 | 0 | 14 | |
| GSE20123 | GDF5 | 8200 | 16 | 0 | 14 | |
| GSE43470 | GDF5 | 8200 | 13 | 0 | 30 | |
| GSE46452 | GDF5 | 8200 | 29 | 0 | 30 | |
| GSE47630 | GDF5 | 8200 | 25 | 0 | 15 | |
| GSE54993 | GDF5 | 8200 | 0 | 17 | 53 | |
| GSE54994 | GDF5 | 8200 | 24 | 0 | 29 | |
| GSE60625 | GDF5 | 8200 | 0 | 0 | 11 | |
| GSE74703 | GDF5 | 8200 | 11 | 0 | 25 | |
| GSE74704 | GDF5 | 8200 | 11 | 0 | 9 | |
| TCGA | GDF5 | 8200 | 49 | 3 | 44 |
Total number of gains: 194; Total number of losses: 20; Total Number of normals: 274.
Somatic mutations of GDF5:
Generating mutation plots.
Highly correlated genes for GDF5:
Showing top 20/683 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GDF5 | KRTAP5-8 | 0.781205 | 4 | 0 | 4 |
| GDF5 | CLC | 0.761746 | 3 | 0 | 3 |
| GDF5 | GABRR2 | 0.755928 | 5 | 0 | 5 |
| GDF5 | MAPK11 | 0.754037 | 3 | 0 | 3 |
| GDF5 | CBL | 0.753472 | 5 | 0 | 5 |
| GDF5 | WDR37 | 0.751318 | 3 | 0 | 3 |
| GDF5 | PHLDB1 | 0.746541 | 5 | 0 | 4 |
| GDF5 | CLDN18 | 0.742128 | 3 | 0 | 3 |
| GDF5 | RHAG | 0.73881 | 3 | 0 | 3 |
| GDF5 | GAK | 0.734693 | 3 | 0 | 3 |
| GDF5 | PRPF40A | 0.729625 | 3 | 0 | 3 |
| GDF5 | VAMP2 | 0.725838 | 3 | 0 | 3 |
| GDF5 | ZMIZ2 | 0.719982 | 3 | 0 | 3 |
| GDF5 | LGI2 | 0.717567 | 3 | 0 | 3 |
| GDF5 | OPHN1 | 0.715141 | 5 | 0 | 4 |
| GDF5 | RAPGEF1 | 0.715117 | 4 | 0 | 4 |
| GDF5 | TAF6L | 0.713961 | 3 | 0 | 3 |
| GDF5 | GP2 | 0.713509 | 4 | 0 | 4 |
| GDF5 | BRINP2 | 0.710415 | 4 | 0 | 4 |
| GDF5 | NEU3 | 0.705764 | 5 | 0 | 5 |
For details and further investigation, click here
