| Full name: matrix metallopeptidase 25 | Alias Symbol: MT6-MMP | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 64386 | HGNC ID: HGNC:14246 | Ensembl Gene: ENSG00000008516 | OMIM ID: 608482 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP25:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP25 | 64386 | 207890_s_at | 0.2068 | 0.4459 | |
| GSE20347 | MMP25 | 64386 | 207890_s_at | -0.0429 | 0.6416 | |
| GSE23400 | MMP25 | 64386 | 207289_at | -0.2402 | 0.0000 | |
| GSE26886 | MMP25 | 64386 | 207890_s_at | 0.0749 | 0.6658 | |
| GSE29001 | MMP25 | 64386 | 207289_at | -0.4772 | 0.0027 | |
| GSE38129 | MMP25 | 64386 | 207890_s_at | -0.1729 | 0.0428 | |
| GSE45670 | MMP25 | 64386 | 207890_s_at | 0.1825 | 0.2072 | |
| GSE53622 | MMP25 | 64386 | 146910 | 0.5906 | 0.0000 | |
| GSE53624 | MMP25 | 64386 | 146910 | 0.3776 | 0.0014 | |
| GSE63941 | MMP25 | 64386 | 207890_s_at | 0.3029 | 0.1802 | |
| GSE77861 | MMP25 | 64386 | 207289_at | -0.1354 | 0.2644 | |
| GSE97050 | MMP25 | 64386 | A_33_P3262124 | 0.4991 | 0.3880 | |
| SRP064894 | MMP25 | 64386 | RNAseq | 0.2530 | 0.4238 | |
| SRP133303 | MMP25 | 64386 | RNAseq | 0.4040 | 0.0376 | |
| SRP159526 | MMP25 | 64386 | RNAseq | 0.6710 | 0.3034 | |
| SRP193095 | MMP25 | 64386 | RNAseq | 1.2158 | 0.0000 | |
| SRP219564 | MMP25 | 64386 | RNAseq | 1.1910 | 0.0049 | |
| TCGA | MMP25 | 64386 | RNAseq | 0.3996 | 0.0246 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MMP25 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP25:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP25 | 64386 | 5 | 5 | 20 | |
| GSE20123 | MMP25 | 64386 | 5 | 4 | 21 | |
| GSE43470 | MMP25 | 64386 | 3 | 8 | 32 | |
| GSE46452 | MMP25 | 64386 | 38 | 1 | 20 | |
| GSE47630 | MMP25 | 64386 | 13 | 6 | 21 | |
| GSE54993 | MMP25 | 64386 | 3 | 5 | 62 | |
| GSE54994 | MMP25 | 64386 | 5 | 9 | 39 | |
| GSE60625 | MMP25 | 64386 | 4 | 0 | 7 | |
| GSE74703 | MMP25 | 64386 | 3 | 6 | 27 | |
| GSE74704 | MMP25 | 64386 | 3 | 2 | 15 | |
| TCGA | MMP25 | 64386 | 19 | 13 | 64 |
Total number of gains: 101; Total number of losses: 59; Total Number of normals: 328.
Somatic mutations of MMP25:
Generating mutation plots.
Highly correlated genes for MMP25:
Showing top 20/667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP25 | MYL3 | 0.733263 | 3 | 0 | 3 |
| MMP25 | GJA3 | 0.713098 | 3 | 0 | 3 |
| MMP25 | BRINP2 | 0.710808 | 4 | 0 | 3 |
| MMP25 | MTUS2 | 0.69829 | 3 | 0 | 3 |
| MMP25 | TMEM132E | 0.697712 | 3 | 0 | 3 |
| MMP25 | RABEP2 | 0.694943 | 3 | 0 | 3 |
| MMP25 | GDAP1L1 | 0.684841 | 4 | 0 | 4 |
| MMP25 | HAGHL | 0.677138 | 3 | 0 | 3 |
| MMP25 | CYLC1 | 0.676289 | 4 | 0 | 4 |
| MMP25 | PITX3 | 0.67594 | 6 | 0 | 6 |
| MMP25 | TSSK1B | 0.675258 | 3 | 0 | 3 |
| MMP25 | CLCNKB | 0.667896 | 5 | 0 | 5 |
| MMP25 | SLC1A7 | 0.666339 | 6 | 0 | 5 |
| MMP25 | DPF1 | 0.665801 | 4 | 0 | 4 |
| MMP25 | FGF21 | 0.662595 | 7 | 0 | 5 |
| MMP25 | ART1 | 0.661907 | 6 | 0 | 4 |
| MMP25 | HTR6 | 0.661811 | 7 | 0 | 7 |
| MMP25 | CD5L | 0.66037 | 5 | 0 | 5 |
| MMP25 | OR2H2 | 0.659586 | 4 | 0 | 4 |
| MMP25 | GJC2 | 0.655495 | 6 | 0 | 5 |
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