| Full name: major histocompatibility complex, class II, DO alpha | Alias Symbol: HLA-D0-alpha | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3111 | HGNC ID: HGNC:4936 | Ensembl Gene: ENSG00000204252 | OMIM ID: 142930 |
| Drug and gene relationship at DGIdb | |||
HLA-DOA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of HLA-DOA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DOA | 3111 | 226878_at | -0.0254 | 0.9858 | |
| GSE20347 | HLA-DOA | 3111 | 211142_x_at | -0.1139 | 0.2051 | |
| GSE23400 | HLA-DOA | 3111 | 217001_x_at | -0.3072 | 0.0000 | |
| GSE26886 | HLA-DOA | 3111 | 211142_x_at | -0.2149 | 0.0524 | |
| GSE29001 | HLA-DOA | 3111 | 217001_x_at | -0.1434 | 0.4285 | |
| GSE38129 | HLA-DOA | 3111 | 211142_x_at | -0.1819 | 0.0600 | |
| GSE45670 | HLA-DOA | 3111 | 211142_x_at | -0.0638 | 0.4858 | |
| GSE53622 | HLA-DOA | 3111 | 28383 | -0.2217 | 0.1900 | |
| GSE53624 | HLA-DOA | 3111 | 28383 | -0.4694 | 0.0022 | |
| GSE63941 | HLA-DOA | 3111 | 211142_x_at | 0.1883 | 0.2540 | |
| GSE77861 | HLA-DOA | 3111 | 211142_x_at | -0.1157 | 0.1400 | |
| GSE97050 | HLA-DOA | 3111 | A_32_P356316 | 0.4110 | 0.3584 | |
| SRP007169 | HLA-DOA | 3111 | RNAseq | 0.0541 | 0.9382 | |
| SRP008496 | HLA-DOA | 3111 | RNAseq | -0.0870 | 0.8550 | |
| SRP064894 | HLA-DOA | 3111 | RNAseq | 0.2048 | 0.4688 | |
| SRP133303 | HLA-DOA | 3111 | RNAseq | -0.1856 | 0.2526 | |
| SRP159526 | HLA-DOA | 3111 | RNAseq | -1.1008 | 0.1991 | |
| SRP193095 | HLA-DOA | 3111 | RNAseq | -0.0723 | 0.6770 | |
| SRP219564 | HLA-DOA | 3111 | RNAseq | 0.7490 | 0.0557 | |
| TCGA | HLA-DOA | 3111 | RNAseq | -0.0275 | 0.8934 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HLA-DOA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DOA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DOA | 3111 | 5 | 0 | 25 | |
| GSE20123 | HLA-DOA | 3111 | 5 | 0 | 25 | |
| GSE43470 | HLA-DOA | 3111 | 5 | 1 | 37 | |
| GSE46452 | HLA-DOA | 3111 | 2 | 9 | 48 | |
| GSE47630 | HLA-DOA | 3111 | 8 | 4 | 28 | |
| GSE54993 | HLA-DOA | 3111 | 3 | 1 | 66 | |
| GSE54994 | HLA-DOA | 3111 | 11 | 4 | 38 | |
| GSE60625 | HLA-DOA | 3111 | 1 | 0 | 10 | |
| GSE74703 | HLA-DOA | 3111 | 5 | 0 | 31 | |
| GSE74704 | HLA-DOA | 3111 | 2 | 0 | 18 |
Total number of gains: 47; Total number of losses: 19; Total Number of normals: 326.
Somatic mutations of HLA-DOA:
Generating mutation plots.
Highly correlated genes for HLA-DOA:
Showing top 20/1022 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DOA | RBP5 | 0.788057 | 3 | 0 | 3 |
| HLA-DOA | MS4A6A | 0.787733 | 5 | 0 | 5 |
| HLA-DOA | MPEG1 | 0.779398 | 4 | 0 | 4 |
| HLA-DOA | BTLA | 0.77082 | 4 | 0 | 4 |
| HLA-DOA | ZBTB33 | 0.754717 | 3 | 0 | 3 |
| HLA-DOA | PHLDB1 | 0.748957 | 6 | 0 | 6 |
| HLA-DOA | CD74 | 0.748698 | 6 | 0 | 5 |
| HLA-DOA | CGA | 0.746681 | 4 | 0 | 4 |
| HLA-DOA | CCR5 | 0.744906 | 3 | 0 | 3 |
| HLA-DOA | ARHGDIB | 0.744756 | 5 | 0 | 5 |
| HLA-DOA | GIMAP7 | 0.744498 | 5 | 0 | 5 |
| HLA-DOA | HVCN1 | 0.740914 | 4 | 0 | 4 |
| HLA-DOA | HLA-DPA1 | 0.73752 | 6 | 0 | 5 |
| HLA-DOA | EPHA5 | 0.737148 | 4 | 0 | 4 |
| HLA-DOA | PARVG | 0.735958 | 6 | 0 | 6 |
| HLA-DOA | SLC6A5 | 0.733325 | 4 | 0 | 4 |
| HLA-DOA | OR10J1 | 0.732946 | 4 | 0 | 4 |
| HLA-DOA | CORO1A | 0.72784 | 5 | 0 | 4 |
| HLA-DOA | PTPRC | 0.727491 | 3 | 0 | 3 |
| HLA-DOA | PSG1 | 0.722656 | 4 | 0 | 4 |
For details and further investigation, click here
