PRKCA

 

Full name: protein kinase C alpha Alias Symbol: PKCα
Type: protein-coding gene Cytoband: 17q24.2
Entrez ID: 5578 HGNC ID: HGNC:9393 Ensembl Gene: ENSG00000154229 OMIM ID: 176960
Drug and gene relationship at DGIdb

 

PRKCA involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04066HIF-1 signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04530Tight junction
hsa04540Gap junction
hsa04650Natural killer cell mediated cytotoxicity
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa05110Vibrio cholerae infection
hsa05130Pathogenic Escherichia coli infection
hsa05161Hepatitis B
hsa05164Influenza A
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of PRKCA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKCA 5578 213093_at -0.9885 0.2886
GSE20347 PRKCA 5578 213093_at 0.4163 0.2032
GSE23400 PRKCA 5578 213093_at -0.1405 0.2720
GSE26886 PRKCA 5578 213093_at 1.4679 0.0055
GSE29001 PRKCA 5578 213093_at 0.3120 0.3557
GSE38129 PRKCA 5578 213093_at -0.0966 0.8171
GSE45670 PRKCA 5578 213093_at -0.6663 0.1202
GSE53622 PRKCA 5578 51065 -0.4234 0.0069
GSE53624 PRKCA 5578 51065 0.0457 0.6918
GSE63941 PRKCA 5578 213093_at -2.8145 0.0165
GSE77861 PRKCA 5578 213093_at 0.8182 0.0576
GSE97050 PRKCA 5578 A_24_P916496 -0.8208 0.1721
SRP007169 PRKCA 5578 RNAseq 1.2276 0.0230
SRP008496 PRKCA 5578 RNAseq 0.9543 0.0152
SRP064894 PRKCA 5578 RNAseq 0.4478 0.0321
SRP133303 PRKCA 5578 RNAseq 0.5739 0.0399
SRP159526 PRKCA 5578 RNAseq 0.6264 0.0330
SRP193095 PRKCA 5578 RNAseq 0.4765 0.0579
SRP219564 PRKCA 5578 RNAseq 0.3951 0.5411
TCGA PRKCA 5578 RNAseq -0.3828 0.0001

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by PRKCA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKCA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKCA 5578 3 2 25
GSE20123 PRKCA 5578 3 2 25
GSE43470 PRKCA 5578 5 0 38
GSE46452 PRKCA 5578 31 1 27
GSE47630 PRKCA 5578 7 1 32
GSE54993 PRKCA 5578 2 5 63
GSE54994 PRKCA 5578 9 4 40
GSE60625 PRKCA 5578 4 2 5
GSE74703 PRKCA 5578 5 0 31
GSE74704 PRKCA 5578 3 1 16
TCGA PRKCA 5578 29 9 58

Total number of gains: 101; Total number of losses: 27; Total Number of normals: 360.  

 

Somatic mutations of PRKCA:

 

Generating mutation plots.

 

Highly correlated genes for PRKCA:

 

Showing top 20/1149 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKCASORCS10.815043303
PRKCATMED80.776747303
PRKCAPREX20.776113303
PRKCATNFSF120.774635303
PRKCAZBED10.757648303
PRKCACYYR10.754292303
PRKCACCDC1210.754034303
PRKCAACO10.753628606
PRKCAMYADM0.750729505
PRKCASLC4A40.742382303
PRKCAKLHL150.739374404
PRKCACTNNA30.737527303
PRKCAFXYD10.731111404
PRKCAZEB10.730748303
PRKCAUSPL10.730094303
PRKCAPPP1R14A0.725173505
PRKCADNM3OS0.723278303
PRKCASESTD10.722447403
PRKCAPDK30.722118504
PRKCAFUNDC20.719301403

For details and further investigation, click here