| Full name: acyl-CoA thioesterase 8 | Alias Symbol: hACTE-III|hTE|PTE-2|NAP1 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 10005 | HGNC ID: HGNC:15919 | Ensembl Gene: ENSG00000101473 | OMIM ID: 608123 |
| Drug and gene relationship at DGIdb | |||
Expression of ACOT8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACOT8 | 10005 | 204212_at | 0.3392 | 0.2928 | |
| GSE20347 | ACOT8 | 10005 | 204212_at | -0.3909 | 0.0008 | |
| GSE23400 | ACOT8 | 10005 | 204212_at | -0.2240 | 0.0000 | |
| GSE26886 | ACOT8 | 10005 | 204212_at | -0.0983 | 0.6267 | |
| GSE29001 | ACOT8 | 10005 | 204212_at | -0.4568 | 0.0271 | |
| GSE38129 | ACOT8 | 10005 | 204212_at | -0.2025 | 0.0679 | |
| GSE45670 | ACOT8 | 10005 | 204212_at | -0.0482 | 0.7092 | |
| GSE53622 | ACOT8 | 10005 | 123445 | -2.3056 | 0.0000 | |
| GSE53624 | ACOT8 | 10005 | 123445 | -1.5058 | 0.0000 | |
| GSE63941 | ACOT8 | 10005 | 204212_at | 0.2112 | 0.6874 | |
| GSE77861 | ACOT8 | 10005 | 204212_at | -0.3752 | 0.0733 | |
| GSE97050 | ACOT8 | 10005 | A_33_P3352544 | -0.4340 | 0.3659 | |
| SRP007169 | ACOT8 | 10005 | RNAseq | -1.1060 | 0.0098 | |
| SRP008496 | ACOT8 | 10005 | RNAseq | -0.8597 | 0.0128 | |
| SRP064894 | ACOT8 | 10005 | RNAseq | 0.3112 | 0.2822 | |
| SRP133303 | ACOT8 | 10005 | RNAseq | -0.0727 | 0.6380 | |
| SRP159526 | ACOT8 | 10005 | RNAseq | -0.1169 | 0.6306 | |
| SRP193095 | ACOT8 | 10005 | RNAseq | -0.6066 | 0.0000 | |
| SRP219564 | ACOT8 | 10005 | RNAseq | -0.0478 | 0.8351 | |
| TCGA | ACOT8 | 10005 | RNAseq | -0.1700 | 0.0030 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ACOT8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACOT8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACOT8 | 10005 | 14 | 1 | 15 | |
| GSE20123 | ACOT8 | 10005 | 14 | 1 | 15 | |
| GSE43470 | ACOT8 | 10005 | 12 | 1 | 30 | |
| GSE46452 | ACOT8 | 10005 | 29 | 0 | 30 | |
| GSE47630 | ACOT8 | 10005 | 24 | 1 | 15 | |
| GSE54993 | ACOT8 | 10005 | 0 | 18 | 52 | |
| GSE54994 | ACOT8 | 10005 | 25 | 0 | 28 | |
| GSE60625 | ACOT8 | 10005 | 0 | 0 | 11 | |
| GSE74703 | ACOT8 | 10005 | 10 | 1 | 25 | |
| GSE74704 | ACOT8 | 10005 | 10 | 0 | 10 | |
| TCGA | ACOT8 | 10005 | 46 | 3 | 47 |
Total number of gains: 184; Total number of losses: 26; Total Number of normals: 278.
Somatic mutations of ACOT8:
Generating mutation plots.
Highly correlated genes for ACOT8:
Showing top 20/505 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACOT8 | NCCRP1 | 0.890951 | 3 | 0 | 3 |
| ACOT8 | IQCF1 | 0.86607 | 4 | 0 | 4 |
| ACOT8 | FAM163B | 0.840019 | 3 | 0 | 3 |
| ACOT8 | KRTAP20-1 | 0.826033 | 3 | 0 | 3 |
| ACOT8 | MUC22 | 0.820012 | 3 | 0 | 3 |
| ACOT8 | ANKRD24 | 0.819366 | 3 | 0 | 3 |
| ACOT8 | TMPRSS11A | 0.816877 | 3 | 0 | 3 |
| ACOT8 | PRSS1 | 0.80436 | 3 | 0 | 3 |
| ACOT8 | KPRP | 0.804347 | 3 | 0 | 3 |
| ACOT8 | MFSD2B | 0.800569 | 3 | 0 | 3 |
| ACOT8 | OTOP3 | 0.800502 | 3 | 0 | 3 |
| ACOT8 | CYP3A7 | 0.795525 | 3 | 0 | 3 |
| ACOT8 | SPRR2F | 0.79485 | 3 | 0 | 3 |
| ACOT8 | MORN3 | 0.79242 | 4 | 0 | 4 |
| ACOT8 | OXT | 0.779418 | 3 | 0 | 3 |
| ACOT8 | SPRR2E | 0.779118 | 3 | 0 | 3 |
| ACOT8 | UPK3B | 0.778234 | 3 | 0 | 3 |
| ACOT8 | APOA1 | 0.774747 | 5 | 0 | 5 |
| ACOT8 | SPRR2A | 0.769419 | 3 | 0 | 3 |
| ACOT8 | RNF222 | 0.763277 | 3 | 0 | 3 |
For details and further investigation, click here
