| Full name: serine protease 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 5644 | HGNC ID: HGNC:9475 | Ensembl Gene: ENSG00000204983 | OMIM ID: 276000 |
| Drug and gene relationship at DGIdb | |||
Expression of PRSS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | PRSS1 | 5644 | 63818 | -2.2876 | 0.0000 | |
| GSE53624 | PRSS1 | 5644 | 63818 | -3.5731 | 0.0000 | |
| GSE97050 | PRSS1 | 5644 | A_23_P380754 | -0.2787 | 0.5851 | |
| TCGA | PRSS1 | 5644 | RNAseq | -5.1905 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PRSS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRSS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRSS1 | 5644 | 3 | 2 | 25 | |
| GSE20123 | PRSS1 | 5644 | 3 | 2 | 25 | |
| GSE43470 | PRSS1 | 5644 | 2 | 4 | 37 | |
| GSE46452 | PRSS1 | 5644 | 7 | 2 | 50 | |
| GSE47630 | PRSS1 | 5644 | 6 | 7 | 27 | |
| GSE54993 | PRSS1 | 5644 | 3 | 4 | 63 | |
| GSE54994 | PRSS1 | 5644 | 5 | 8 | 40 | |
| GSE60625 | PRSS1 | 5644 | 0 | 0 | 11 | |
| GSE74703 | PRSS1 | 5644 | 2 | 4 | 30 | |
| GSE74704 | PRSS1 | 5644 | 1 | 2 | 17 | |
| TCGA | PRSS1 | 5644 | 29 | 23 | 44 |
Total number of gains: 61; Total number of losses: 58; Total Number of normals: 369.
Somatic mutations of PRSS1:
Generating mutation plots.
Highly correlated genes for PRSS1:
Showing top 20/264 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRSS1 | PRSS3 | 0.855415 | 3 | 0 | 3 |
| PRSS1 | SCNN1B | 0.813022 | 3 | 0 | 3 |
| PRSS1 | ACOT8 | 0.80436 | 3 | 0 | 3 |
| PRSS1 | DEGS2 | 0.784519 | 3 | 0 | 3 |
| PRSS1 | SPRR3 | 0.77552 | 3 | 0 | 3 |
| PRSS1 | IL36A | 0.77497 | 3 | 0 | 3 |
| PRSS1 | CLCA4 | 0.766432 | 3 | 0 | 3 |
| PRSS1 | SLURP1 | 0.766356 | 3 | 0 | 3 |
| PRSS1 | VSIG10L | 0.765142 | 3 | 0 | 3 |
| PRSS1 | GDPD3 | 0.762381 | 3 | 0 | 3 |
| PRSS1 | CD24 | 0.760843 | 3 | 0 | 3 |
| PRSS1 | NCCRP1 | 0.760723 | 3 | 0 | 3 |
| PRSS1 | PRSS27 | 0.758187 | 3 | 0 | 3 |
| PRSS1 | RHCG | 0.757691 | 3 | 0 | 3 |
| PRSS1 | SPINK5 | 0.755442 | 3 | 0 | 3 |
| PRSS1 | IQCF1 | 0.754137 | 3 | 0 | 3 |
| PRSS1 | VSIG2 | 0.754133 | 3 | 0 | 3 |
| PRSS1 | CRCT1 | 0.753541 | 3 | 0 | 3 |
| PRSS1 | EPS8L1 | 0.749245 | 3 | 0 | 3 |
| PRSS1 | C1orf116 | 0.746394 | 3 | 0 | 3 |
For details and further investigation, click here
