| Full name: oxytocin/neurophysin I prepropeptide | Alias Symbol: OXT-NPI|OT-NPI | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 5020 | HGNC ID: HGNC:8528 | Ensembl Gene: ENSG00000101405 | OMIM ID: 167050 |
| Drug and gene relationship at DGIdb | |||
OXT involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04921 | Oxytocin signaling pathway |
Expression of OXT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OXT | 5020 | 207576_x_at | 0.1090 | 0.6093 | |
| GSE20347 | OXT | 5020 | 207576_x_at | -0.0697 | 0.3255 | |
| GSE23400 | OXT | 5020 | 207576_x_at | -0.0601 | 0.0763 | |
| GSE26886 | OXT | 5020 | 207576_x_at | 0.2236 | 0.1496 | |
| GSE29001 | OXT | 5020 | 207576_x_at | -0.2099 | 0.2306 | |
| GSE38129 | OXT | 5020 | 207576_x_at | -0.0540 | 0.4582 | |
| GSE45670 | OXT | 5020 | 207576_x_at | 0.0924 | 0.2939 | |
| GSE53622 | OXT | 5020 | 36926 | -1.6868 | 0.0000 | |
| GSE53624 | OXT | 5020 | 36926 | -1.6493 | 0.0000 | |
| GSE63941 | OXT | 5020 | 207576_x_at | 0.0679 | 0.7436 | |
| GSE77861 | OXT | 5020 | 207576_x_at | 0.0358 | 0.8416 | |
| GSE97050 | OXT | 5020 | A_24_P382579 | -0.3301 | 0.3552 | |
| TCGA | OXT | 5020 | RNAseq | 1.4404 | 0.0543 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by OXT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OXT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OXT | 5020 | 12 | 3 | 15 | |
| GSE20123 | OXT | 5020 | 13 | 3 | 14 | |
| GSE43470 | OXT | 5020 | 10 | 1 | 32 | |
| GSE46452 | OXT | 5020 | 26 | 1 | 32 | |
| GSE47630 | OXT | 5020 | 18 | 4 | 18 | |
| GSE54993 | OXT | 5020 | 2 | 14 | 54 | |
| GSE54994 | OXT | 5020 | 24 | 2 | 27 | |
| GSE60625 | OXT | 5020 | 0 | 0 | 11 | |
| GSE74703 | OXT | 5020 | 9 | 1 | 26 | |
| GSE74704 | OXT | 5020 | 8 | 1 | 11 | |
| TCGA | OXT | 5020 | 40 | 11 | 45 |
Total number of gains: 162; Total number of losses: 41; Total Number of normals: 285.
Somatic mutations of OXT:
Generating mutation plots.
Highly correlated genes for OXT:
Showing top 20/493 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OXT | OR5AS1 | 0.834028 | 3 | 0 | 3 |
| OXT | NCCRP1 | 0.8067 | 3 | 0 | 3 |
| OXT | KPRP | 0.786505 | 3 | 0 | 3 |
| OXT | ACOT8 | 0.779418 | 3 | 0 | 3 |
| OXT | TMPRSS11E | 0.76736 | 3 | 0 | 3 |
| OXT | TMPRSS11A | 0.754581 | 3 | 0 | 3 |
| OXT | BLVRB | 0.753476 | 3 | 0 | 3 |
| OXT | OR2Z1 | 0.750708 | 3 | 0 | 3 |
| OXT | OTOP3 | 0.744417 | 3 | 0 | 3 |
| OXT | KRTAP20-1 | 0.742398 | 3 | 0 | 3 |
| OXT | MFSD2B | 0.740105 | 3 | 0 | 3 |
| OXT | FAM163B | 0.739033 | 3 | 0 | 3 |
| OXT | SPRR2D | 0.738799 | 3 | 0 | 3 |
| OXT | GPX6 | 0.733971 | 3 | 0 | 3 |
| OXT | FAM180B | 0.731213 | 3 | 0 | 3 |
| OXT | UPK3B | 0.73071 | 3 | 0 | 3 |
| OXT | DGCR5 | 0.729377 | 4 | 0 | 4 |
| OXT | IL2 | 0.728415 | 3 | 0 | 3 |
| OXT | C3orf20 | 0.728069 | 4 | 0 | 3 |
| OXT | HAMP | 0.727887 | 4 | 0 | 4 |
For details and further investigation, click here
