| Full name: oxysterol binding protein like 6 | Alias Symbol: ORP6 | ||
| Type: protein-coding gene | Cytoband: 2q31.2 | ||
| Entrez ID: 114880 | HGNC ID: HGNC:16388 | Ensembl Gene: ENSG00000079156 | OMIM ID: 606734 |
| Drug and gene relationship at DGIdb | |||
Expression of OSBPL6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OSBPL6 | 114880 | 223805_at | 0.4069 | 0.7692 | |
| GSE26886 | OSBPL6 | 114880 | 223805_at | -0.4921 | 0.2671 | |
| GSE45670 | OSBPL6 | 114880 | 223805_at | 0.3480 | 0.2165 | |
| GSE53622 | OSBPL6 | 114880 | 31364 | 0.1202 | 0.4064 | |
| GSE53624 | OSBPL6 | 114880 | 121602 | 0.4126 | 0.0001 | |
| GSE63941 | OSBPL6 | 114880 | 223805_at | -0.9858 | 0.2951 | |
| GSE77861 | OSBPL6 | 114880 | 223805_at | 0.3007 | 0.2108 | |
| GSE97050 | OSBPL6 | 114880 | A_33_P3255194 | 0.1745 | 0.6270 | |
| SRP007169 | OSBPL6 | 114880 | RNAseq | 1.0797 | 0.0277 | |
| SRP008496 | OSBPL6 | 114880 | RNAseq | 1.0071 | 0.0080 | |
| SRP064894 | OSBPL6 | 114880 | RNAseq | 0.3070 | 0.1338 | |
| SRP133303 | OSBPL6 | 114880 | RNAseq | -0.1176 | 0.6399 | |
| SRP159526 | OSBPL6 | 114880 | RNAseq | -0.1281 | 0.6562 | |
| SRP193095 | OSBPL6 | 114880 | RNAseq | 0.2612 | 0.3341 | |
| SRP219564 | OSBPL6 | 114880 | RNAseq | -0.6255 | 0.1100 | |
| TCGA | OSBPL6 | 114880 | RNAseq | 0.5109 | 0.0002 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by OSBPL6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OSBPL6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OSBPL6 | 114880 | 8 | 0 | 22 | |
| GSE20123 | OSBPL6 | 114880 | 8 | 0 | 22 | |
| GSE43470 | OSBPL6 | 114880 | 5 | 1 | 37 | |
| GSE46452 | OSBPL6 | 114880 | 1 | 4 | 54 | |
| GSE47630 | OSBPL6 | 114880 | 4 | 4 | 32 | |
| GSE54993 | OSBPL6 | 114880 | 0 | 5 | 65 | |
| GSE54994 | OSBPL6 | 114880 | 11 | 4 | 38 | |
| GSE60625 | OSBPL6 | 114880 | 0 | 3 | 8 | |
| GSE74703 | OSBPL6 | 114880 | 4 | 1 | 31 | |
| GSE74704 | OSBPL6 | 114880 | 5 | 0 | 15 | |
| TCGA | OSBPL6 | 114880 | 29 | 5 | 62 |
Total number of gains: 75; Total number of losses: 27; Total Number of normals: 386.
Somatic mutations of OSBPL6:
Generating mutation plots.
Highly correlated genes for OSBPL6:
Showing top 20/150 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OSBPL6 | PSMA4 | 0.764054 | 3 | 0 | 3 |
| OSBPL6 | IKBIP | 0.761759 | 3 | 0 | 3 |
| OSBPL6 | PLAT | 0.756315 | 3 | 0 | 3 |
| OSBPL6 | PDE8A | 0.734431 | 3 | 0 | 3 |
| OSBPL6 | CPT1A | 0.727903 | 3 | 0 | 3 |
| OSBPL6 | ZC3H12C | 0.722492 | 3 | 0 | 3 |
| OSBPL6 | BRAT1 | 0.713673 | 3 | 0 | 3 |
| OSBPL6 | AFAP1L2 | 0.702444 | 3 | 0 | 3 |
| OSBPL6 | TNFRSF21 | 0.697971 | 3 | 0 | 3 |
| OSBPL6 | TM2D3 | 0.697917 | 3 | 0 | 3 |
| OSBPL6 | ABCB6 | 0.695851 | 3 | 0 | 3 |
| OSBPL6 | NIF3L1 | 0.692846 | 3 | 0 | 3 |
| OSBPL6 | CTSB | 0.683078 | 3 | 0 | 3 |
| OSBPL6 | ACSL4 | 0.681127 | 3 | 0 | 3 |
| OSBPL6 | MANEA | 0.677982 | 3 | 0 | 3 |
| OSBPL6 | USP45 | 0.676652 | 4 | 0 | 3 |
| OSBPL6 | UBXN2A | 0.676571 | 4 | 0 | 3 |
| OSBPL6 | THOC1 | 0.674208 | 3 | 0 | 3 |
| OSBPL6 | GRPEL1 | 0.673233 | 3 | 0 | 3 |
| OSBPL6 | CNTNAP2 | 0.671389 | 3 | 0 | 3 |
For details and further investigation, click here
