GNGT2

 

Full name: G protein subunit gamma transducin 2 Alias Symbol: GNG9
Type: protein-coding gene Cytoband: 17q21
Entrez ID: 2793 HGNC ID: HGNC:4412 Ensembl Gene: ENSG00000167083 OMIM ID: 139391
Drug and gene relationship at DGIdb

 

GNGT2 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNGT2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNGT2 2793 235139_at 0.0662 0.8690
GSE26886 GNGT2 2793 235139_at -0.1239 0.4447
GSE45670 GNGT2 2793 235139_at 0.0030 0.9799
GSE53622 GNGT2 2793 18842 -0.2018 0.1204
GSE53624 GNGT2 2793 18842 -0.0539 0.7594
GSE63941 GNGT2 2793 235139_at -0.1556 0.2814
GSE77861 GNGT2 2793 235139_at -0.1895 0.1193
GSE97050 GNGT2 2793 A_23_P26994 0.1755 0.3910
SRP133303 GNGT2 2793 RNAseq -0.3165 0.3888
SRP159526 GNGT2 2793 RNAseq -0.5483 0.4780
SRP219564 GNGT2 2793 RNAseq 0.4867 0.4281
TCGA GNGT2 2793 RNAseq 0.3413 0.1853

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GNGT2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNGT2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNGT2 2793 6 2 22
GSE20123 GNGT2 2793 6 2 22
GSE43470 GNGT2 2793 3 2 38
GSE46452 GNGT2 2793 32 0 27
GSE47630 GNGT2 2793 9 0 31
GSE54993 GNGT2 2793 2 4 64
GSE54994 GNGT2 2793 10 6 37
GSE60625 GNGT2 2793 4 0 7
GSE74703 GNGT2 2793 3 2 31
GSE74704 GNGT2 2793 4 1 15
TCGA GNGT2 2793 27 7 62

Total number of gains: 106; Total number of losses: 26; Total Number of normals: 356.  

 

Somatic mutations of GNGT2:

 

Generating mutation plots.

 

Highly correlated genes for GNGT2:

 

Showing top 20/364 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNGT2PDE4B0.812344303
GNGT2KCNAB20.801937303
GNGT2ITGAM0.796036303
GNGT2IL2RB0.794732303
GNGT2CST70.781248505
GNGT2RHOH0.774736404
GNGT2SNX120.773302303
GNGT2SH3BP50.772777303
GNGT2TRAT10.764987303
GNGT2PIK3CG0.760482303
GNGT2CLDND20.755097303
GNGT2C16orf540.751829404
GNGT2MPP10.749035303
GNGT2SNX200.748903505
GNGT2CCL50.748462404
GNGT2FLI10.747938404
GNGT2PTPN220.746991303
GNGT2BNIP10.746055303
GNGT2SPI10.740762505
GNGT2DCTN30.731977303

For details and further investigation, click here