| Full name: roundabout guidance receptor 1 | Alias Symbol: DUTT1|FLJ21882|SAX3 | ||
| Type: protein-coding gene | Cytoband: 3p12.3 | ||
| Entrez ID: 6091 | HGNC ID: HGNC:10249 | Ensembl Gene: ENSG00000169855 | OMIM ID: 602430 |
| Drug and gene relationship at DGIdb | |||
ROBO1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of ROBO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ROBO1 | 6091 | 213194_at | 0.1274 | 0.9138 | |
| GSE20347 | ROBO1 | 6091 | 213194_at | -0.3421 | 0.4067 | |
| GSE23400 | ROBO1 | 6091 | 213194_at | 0.1172 | 0.5479 | |
| GSE26886 | ROBO1 | 6091 | 213194_at | -0.0204 | 0.9778 | |
| GSE29001 | ROBO1 | 6091 | 213194_at | -0.7019 | 0.4079 | |
| GSE38129 | ROBO1 | 6091 | 213194_at | 0.0411 | 0.9049 | |
| GSE45670 | ROBO1 | 6091 | 213194_at | 0.0731 | 0.8427 | |
| GSE53622 | ROBO1 | 6091 | 128988 | 0.2032 | 0.1410 | |
| GSE53624 | ROBO1 | 6091 | 128988 | -0.2437 | 0.0167 | |
| GSE63941 | ROBO1 | 6091 | 213194_at | -4.5422 | 0.0048 | |
| GSE77861 | ROBO1 | 6091 | 213194_at | -0.3751 | 0.3673 | |
| GSE97050 | ROBO1 | 6091 | A_23_P80503 | 0.8609 | 0.1069 | |
| SRP007169 | ROBO1 | 6091 | RNAseq | -0.2574 | 0.5968 | |
| SRP008496 | ROBO1 | 6091 | RNAseq | -0.1410 | 0.6974 | |
| SRP064894 | ROBO1 | 6091 | RNAseq | -0.1954 | 0.4988 | |
| SRP133303 | ROBO1 | 6091 | RNAseq | 0.0675 | 0.8023 | |
| SRP159526 | ROBO1 | 6091 | RNAseq | -0.2917 | 0.2912 | |
| SRP193095 | ROBO1 | 6091 | RNAseq | 0.2192 | 0.3950 | |
| SRP219564 | ROBO1 | 6091 | RNAseq | 0.6575 | 0.3697 | |
| TCGA | ROBO1 | 6091 | RNAseq | 0.1872 | 0.0741 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ROBO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ROBO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ROBO1 | 6091 | 2 | 18 | 10 | |
| GSE20123 | ROBO1 | 6091 | 2 | 18 | 10 | |
| GSE43470 | ROBO1 | 6091 | 0 | 22 | 21 | |
| GSE46452 | ROBO1 | 6091 | 2 | 17 | 40 | |
| GSE47630 | ROBO1 | 6091 | 3 | 20 | 17 | |
| GSE54993 | ROBO1 | 6091 | 4 | 3 | 63 | |
| GSE54994 | ROBO1 | 6091 | 1 | 30 | 22 | |
| GSE60625 | ROBO1 | 6091 | 3 | 1 | 7 | |
| GSE74703 | ROBO1 | 6091 | 0 | 19 | 17 | |
| GSE74704 | ROBO1 | 6091 | 1 | 13 | 6 | |
| TCGA | ROBO1 | 6091 | 1 | 78 | 17 |
Total number of gains: 19; Total number of losses: 239; Total Number of normals: 230.
Somatic mutations of ROBO1:
Generating mutation plots.
Highly correlated genes for ROBO1:
Showing top 20/140 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ROBO1 | SERPINB9 | 0.772593 | 3 | 0 | 3 |
| ROBO1 | CASP4 | 0.769192 | 3 | 0 | 3 |
| ROBO1 | RAB7B | 0.765296 | 3 | 0 | 3 |
| ROBO1 | RAD17 | 0.731654 | 4 | 0 | 4 |
| ROBO1 | ALDH7A1 | 0.722719 | 3 | 0 | 3 |
| ROBO1 | SH3RF3 | 0.717481 | 3 | 0 | 3 |
| ROBO1 | MTMR6 | 0.715484 | 3 | 0 | 3 |
| ROBO1 | APBB1IP | 0.71428 | 3 | 0 | 3 |
| ROBO1 | AP3S1 | 0.712143 | 3 | 0 | 3 |
| ROBO1 | ACSL5 | 0.711936 | 3 | 0 | 3 |
| ROBO1 | ANXA5 | 0.711859 | 3 | 0 | 3 |
| ROBO1 | ARG2 | 0.710241 | 3 | 0 | 3 |
| ROBO1 | ANKHD1 | 0.707581 | 3 | 0 | 3 |
| ROBO1 | MLKL | 0.705874 | 3 | 0 | 3 |
| ROBO1 | TMEM123 | 0.704952 | 3 | 0 | 3 |
| ROBO1 | KCNK6 | 0.701645 | 3 | 0 | 3 |
| ROBO1 | ELMOD2 | 0.699774 | 3 | 0 | 3 |
| ROBO1 | ANPEP | 0.699655 | 3 | 0 | 3 |
| ROBO1 | KDM5B | 0.688824 | 3 | 0 | 3 |
| ROBO1 | PRRC1 | 0.680771 | 3 | 0 | 3 |
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