| Full name: phosphofructokinase, liver type | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 5211 | HGNC ID: HGNC:8876 | Ensembl Gene: ENSG00000141959 | OMIM ID: 171860 |
| Drug and gene relationship at DGIdb | |||
PFKL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa04152 | AMPK signaling pathway | |
| hsa04922 | Glucagon signaling pathway |
Expression of PFKL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PFKL | 5211 | 211065_x_at | 0.2066 | 0.6430 | |
| GSE20347 | PFKL | 5211 | 211065_x_at | -0.3866 | 0.0001 | |
| GSE23400 | PFKL | 5211 | 211065_x_at | -0.2610 | 0.0001 | |
| GSE26886 | PFKL | 5211 | 211065_x_at | -0.5664 | 0.0007 | |
| GSE29001 | PFKL | 5211 | 211065_x_at | -0.2767 | 0.1342 | |
| GSE38129 | PFKL | 5211 | 211065_x_at | -0.2275 | 0.0106 | |
| GSE45670 | PFKL | 5211 | 211065_x_at | -0.0710 | 0.5320 | |
| GSE53622 | PFKL | 5211 | 44797 | -0.2706 | 0.0001 | |
| GSE53624 | PFKL | 5211 | 44797 | -0.1860 | 0.0107 | |
| GSE63941 | PFKL | 5211 | 211065_x_at | 0.2131 | 0.5024 | |
| GSE77861 | PFKL | 5211 | 201102_s_at | -0.3411 | 0.0963 | |
| GSE97050 | PFKL | 5211 | A_23_P29079 | -0.0647 | 0.8130 | |
| SRP007169 | PFKL | 5211 | RNAseq | -1.5841 | 0.0023 | |
| SRP008496 | PFKL | 5211 | RNAseq | -1.4490 | 0.0000 | |
| SRP064894 | PFKL | 5211 | RNAseq | -0.0086 | 0.9678 | |
| SRP133303 | PFKL | 5211 | RNAseq | -0.4781 | 0.0004 | |
| SRP159526 | PFKL | 5211 | RNAseq | -0.1492 | 0.2525 | |
| SRP193095 | PFKL | 5211 | RNAseq | -0.4127 | 0.0005 | |
| SRP219564 | PFKL | 5211 | RNAseq | -0.3833 | 0.1192 | |
| TCGA | PFKL | 5211 | RNAseq | -0.0591 | 0.1816 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PFKL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PFKL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PFKL | 5211 | 2 | 8 | 20 | |
| GSE20123 | PFKL | 5211 | 2 | 8 | 20 | |
| GSE43470 | PFKL | 5211 | 0 | 13 | 30 | |
| GSE46452 | PFKL | 5211 | 1 | 21 | 37 | |
| GSE47630 | PFKL | 5211 | 6 | 17 | 17 | |
| GSE54993 | PFKL | 5211 | 8 | 1 | 61 | |
| GSE54994 | PFKL | 5211 | 4 | 8 | 41 | |
| GSE60625 | PFKL | 5211 | 0 | 0 | 11 | |
| GSE74703 | PFKL | 5211 | 0 | 10 | 26 | |
| GSE74704 | PFKL | 5211 | 1 | 4 | 15 | |
| TCGA | PFKL | 5211 | 8 | 39 | 49 |
Total number of gains: 32; Total number of losses: 129; Total Number of normals: 327.
Somatic mutations of PFKL:
Generating mutation plots.
Highly correlated genes for PFKL:
Showing top 20/928 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PFKL | COG3 | 0.78337 | 3 | 0 | 3 |
| PFKL | JOSD2 | 0.781119 | 3 | 0 | 3 |
| PFKL | POLN | 0.766454 | 3 | 0 | 3 |
| PFKL | TSEN34 | 0.748699 | 3 | 0 | 3 |
| PFKL | MAPK11 | 0.747756 | 3 | 0 | 3 |
| PFKL | NLGN3 | 0.736835 | 3 | 0 | 3 |
| PFKL | CDH24 | 0.736307 | 3 | 0 | 3 |
| PFKL | ZNF416 | 0.722783 | 4 | 0 | 4 |
| PFKL | CCDC12 | 0.721816 | 3 | 0 | 3 |
| PFKL | RNFT2 | 0.706628 | 3 | 0 | 3 |
| PFKL | C1orf159 | 0.704974 | 4 | 0 | 3 |
| PFKL | LACTBL1 | 0.70454 | 3 | 0 | 3 |
| PFKL | SPRY1 | 0.700342 | 3 | 0 | 3 |
| PFKL | CPTP | 0.69383 | 6 | 0 | 6 |
| PFKL | MED15 | 0.691001 | 3 | 0 | 3 |
| PFKL | MEAF6 | 0.68945 | 3 | 0 | 3 |
| PFKL | ZNF287 | 0.689272 | 4 | 0 | 3 |
| PFKL | ANKRD54 | 0.68895 | 3 | 0 | 3 |
| PFKL | GRN | 0.686134 | 8 | 0 | 6 |
| PFKL | SLC25A39 | 0.685712 | 5 | 0 | 5 |
For details and further investigation, click here
