| Full name: acyl-CoA synthetase long chain family member 6 | Alias Symbol: KIAA0837|ACS2|LACS5|LACS2 | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 23305 | HGNC ID: HGNC:16496 | Ensembl Gene: ENSG00000164398 | OMIM ID: 604443 |
| Drug and gene relationship at DGIdb | |||
ACSL6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway |
Expression of ACSL6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACSL6 | 23305 | 216409_at | -0.1492 | 0.5413 | |
| GSE20347 | ACSL6 | 23305 | 216409_at | -0.0578 | 0.5164 | |
| GSE23400 | ACSL6 | 23305 | 216409_at | -0.1217 | 0.0094 | |
| GSE26886 | ACSL6 | 23305 | 216409_at | -0.0208 | 0.8684 | |
| GSE29001 | ACSL6 | 23305 | 216409_at | -0.1116 | 0.5910 | |
| GSE38129 | ACSL6 | 23305 | 216409_at | -0.1458 | 0.0572 | |
| GSE45670 | ACSL6 | 23305 | 216409_at | 0.1222 | 0.2274 | |
| GSE53622 | ACSL6 | 23305 | 49280 | -1.1485 | 0.0000 | |
| GSE53624 | ACSL6 | 23305 | 49280 | -0.5366 | 0.0000 | |
| GSE63941 | ACSL6 | 23305 | 216409_at | 0.1733 | 0.3161 | |
| GSE77861 | ACSL6 | 23305 | 216409_at | -0.1210 | 0.3072 | |
| GSE97050 | ACSL6 | 23305 | A_33_P3390656 | -0.4102 | 0.1936 | |
| SRP007169 | ACSL6 | 23305 | RNAseq | 0.5564 | 0.4913 | |
| SRP064894 | ACSL6 | 23305 | RNAseq | -0.8038 | 0.0215 | |
| SRP133303 | ACSL6 | 23305 | RNAseq | -0.5610 | 0.0116 | |
| SRP159526 | ACSL6 | 23305 | RNAseq | 1.5716 | 0.0621 | |
| SRP193095 | ACSL6 | 23305 | RNAseq | -0.4487 | 0.0649 | |
| SRP219564 | ACSL6 | 23305 | RNAseq | -0.5413 | 0.3696 | |
| TCGA | ACSL6 | 23305 | RNAseq | -0.7614 | 0.2356 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ACSL6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACSL6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACSL6 | 23305 | 1 | 11 | 18 | |
| GSE20123 | ACSL6 | 23305 | 1 | 11 | 18 | |
| GSE43470 | ACSL6 | 23305 | 2 | 9 | 32 | |
| GSE46452 | ACSL6 | 23305 | 0 | 27 | 32 | |
| GSE47630 | ACSL6 | 23305 | 0 | 21 | 19 | |
| GSE54993 | ACSL6 | 23305 | 9 | 1 | 60 | |
| GSE54994 | ACSL6 | 23305 | 2 | 14 | 37 | |
| GSE60625 | ACSL6 | 23305 | 0 | 0 | 11 | |
| GSE74703 | ACSL6 | 23305 | 2 | 6 | 28 | |
| GSE74704 | ACSL6 | 23305 | 1 | 5 | 14 | |
| TCGA | ACSL6 | 23305 | 3 | 39 | 54 |
Total number of gains: 21; Total number of losses: 144; Total Number of normals: 323.
Somatic mutations of ACSL6:
Generating mutation plots.
Highly correlated genes for ACSL6:
Showing top 20/668 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACSL6 | GTF2IRD2B | 0.751774 | 3 | 0 | 3 |
| ACSL6 | CGA | 0.739799 | 3 | 0 | 3 |
| ACSL6 | OBSL1 | 0.722024 | 3 | 0 | 3 |
| ACSL6 | GRIP2 | 0.698407 | 4 | 0 | 4 |
| ACSL6 | LGI2 | 0.68999 | 3 | 0 | 3 |
| ACSL6 | CYP2A6 | 0.689936 | 3 | 0 | 3 |
| ACSL6 | SPX | 0.689384 | 3 | 0 | 3 |
| ACSL6 | VWA7 | 0.68136 | 4 | 0 | 4 |
| ACSL6 | PDYN | 0.672773 | 3 | 0 | 3 |
| ACSL6 | MAML3 | 0.669118 | 4 | 0 | 4 |
| ACSL6 | TUBB4A | 0.668594 | 4 | 0 | 4 |
| ACSL6 | HAO2 | 0.66755 | 3 | 0 | 3 |
| ACSL6 | GNRH2 | 0.665476 | 4 | 0 | 4 |
| ACSL6 | CXCR1 | 0.665049 | 4 | 0 | 4 |
| ACSL6 | GRIK5 | 0.65986 | 5 | 0 | 5 |
| ACSL6 | ZC3H6 | 0.652746 | 4 | 0 | 3 |
| ACSL6 | DAB1 | 0.65028 | 4 | 0 | 3 |
| ACSL6 | IFNA4 | 0.650201 | 4 | 0 | 3 |
| ACSL6 | MYL7 | 0.646071 | 3 | 0 | 3 |
| ACSL6 | HOXA3 | 0.642873 | 4 | 0 | 4 |
For details and further investigation, click here
