| Full name: activin A receptor type 1B | Alias Symbol: ALK4|SKR2|ActRIB | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 91 | HGNC ID: HGNC:172 | Ensembl Gene: ENSG00000135503 | OMIM ID: 601300 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ACVR1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of ACVR1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACVR1B | 91 | 213198_at | -0.2731 | 0.5357 | |
| GSE20347 | ACVR1B | 91 | 213198_at | -0.2693 | 0.0920 | |
| GSE23400 | ACVR1B | 91 | 213198_at | -0.2129 | 0.0023 | |
| GSE26886 | ACVR1B | 91 | 213198_at | -0.3799 | 0.1594 | |
| GSE29001 | ACVR1B | 91 | 213198_at | -0.2253 | 0.3186 | |
| GSE38129 | ACVR1B | 91 | 213198_at | 0.0431 | 0.8162 | |
| GSE45670 | ACVR1B | 91 | 213198_at | -0.2326 | 0.1482 | |
| GSE53622 | ACVR1B | 91 | 31590 | -0.1743 | 0.0477 | |
| GSE53624 | ACVR1B | 91 | 31590 | -0.3458 | 0.0001 | |
| GSE63941 | ACVR1B | 91 | 213198_at | 0.4686 | 0.2196 | |
| GSE77861 | ACVR1B | 91 | 213198_at | -0.4501 | 0.0069 | |
| GSE97050 | ACVR1B | 91 | A_33_P3364433 | -0.1849 | 0.6699 | |
| SRP007169 | ACVR1B | 91 | RNAseq | -0.2113 | 0.6083 | |
| SRP008496 | ACVR1B | 91 | RNAseq | -0.2501 | 0.3614 | |
| SRP064894 | ACVR1B | 91 | RNAseq | -0.6447 | 0.0008 | |
| SRP133303 | ACVR1B | 91 | RNAseq | -0.0523 | 0.7070 | |
| SRP159526 | ACVR1B | 91 | RNAseq | -0.0148 | 0.9705 | |
| SRP193095 | ACVR1B | 91 | RNAseq | -0.4816 | 0.0002 | |
| SRP219564 | ACVR1B | 91 | RNAseq | -0.6123 | 0.0810 | |
| TCGA | ACVR1B | 91 | RNAseq | -0.1180 | 0.0404 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ACVR1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACVR1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACVR1B | 91 | 8 | 2 | 20 | |
| GSE20123 | ACVR1B | 91 | 8 | 1 | 21 | |
| GSE43470 | ACVR1B | 91 | 4 | 0 | 39 | |
| GSE46452 | ACVR1B | 91 | 7 | 1 | 51 | |
| GSE47630 | ACVR1B | 91 | 10 | 2 | 28 | |
| GSE54993 | ACVR1B | 91 | 0 | 5 | 65 | |
| GSE54994 | ACVR1B | 91 | 3 | 2 | 48 | |
| GSE60625 | ACVR1B | 91 | 0 | 0 | 11 | |
| GSE74703 | ACVR1B | 91 | 3 | 0 | 33 | |
| GSE74704 | ACVR1B | 91 | 5 | 1 | 14 | |
| TCGA | ACVR1B | 91 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 25; Total Number of normals: 402.
Somatic mutations of ACVR1B:
Generating mutation plots.
Highly correlated genes for ACVR1B:
Showing top 20/757 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACVR1B | C6orf120 | 0.761179 | 3 | 0 | 3 |
| ACVR1B | ZNF175 | 0.755999 | 3 | 0 | 3 |
| ACVR1B | GNL3 | 0.746414 | 4 | 0 | 3 |
| ACVR1B | ZNF91 | 0.737164 | 3 | 0 | 3 |
| ACVR1B | ZNF213 | 0.734362 | 3 | 0 | 3 |
| ACVR1B | CASP9 | 0.731736 | 4 | 0 | 4 |
| ACVR1B | C1orf50 | 0.729607 | 3 | 0 | 3 |
| ACVR1B | PCTP | 0.727029 | 3 | 0 | 3 |
| ACVR1B | CDC16 | 0.726451 | 3 | 0 | 3 |
| ACVR1B | PPP1R11 | 0.72593 | 3 | 0 | 3 |
| ACVR1B | DLL1 | 0.725183 | 3 | 0 | 3 |
| ACVR1B | CAPZB | 0.723876 | 4 | 0 | 3 |
| ACVR1B | GNG5 | 0.722206 | 4 | 0 | 3 |
| ACVR1B | PHYHD1 | 0.721736 | 3 | 0 | 3 |
| ACVR1B | LAPTM4A | 0.717475 | 3 | 0 | 3 |
| ACVR1B | PARG | 0.707241 | 3 | 0 | 3 |
| ACVR1B | MTM1 | 0.706645 | 3 | 0 | 3 |
| ACVR1B | WBP2 | 0.703192 | 3 | 0 | 3 |
| ACVR1B | ZNF627 | 0.70295 | 3 | 0 | 3 |
| ACVR1B | SPRYD4 | 0.699526 | 4 | 0 | 3 |
For details and further investigation, click here
