| Full name: G protein nucleolar 3 | Alias Symbol: C77032|E2IG3|MGC800|NS | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 26354 | HGNC ID: HGNC:29931 | Ensembl Gene: ENSG00000163938 | OMIM ID: 608011 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GNL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNL3 | 26354 | 228395_at | -0.2324 | 0.8164 | |
| GSE26886 | GNL3 | 26354 | 228395_at | -0.2301 | 0.2361 | |
| GSE45670 | GNL3 | 26354 | 228395_at | -0.4799 | 0.0069 | |
| GSE53622 | GNL3 | 26354 | 41294 | -0.5546 | 0.0000 | |
| GSE53624 | GNL3 | 26354 | 41294 | -0.6163 | 0.0000 | |
| GSE63941 | GNL3 | 26354 | 228395_at | -0.2487 | 0.4364 | |
| GSE77861 | GNL3 | 26354 | 228395_at | -0.1843 | 0.0392 | |
| GSE97050 | GNL3 | 26354 | A_23_P41025 | -0.0243 | 0.9731 | |
| SRP007169 | GNL3 | 26354 | RNAseq | -1.0466 | 0.0005 | |
| SRP008496 | GNL3 | 26354 | RNAseq | -0.9081 | 0.0000 | |
| SRP064894 | GNL3 | 26354 | RNAseq | -0.6532 | 0.0001 | |
| SRP133303 | GNL3 | 26354 | RNAseq | -0.2823 | 0.1640 | |
| SRP159526 | GNL3 | 26354 | RNAseq | -0.6062 | 0.0302 | |
| SRP193095 | GNL3 | 26354 | RNAseq | -0.7654 | 0.0000 | |
| SRP219564 | GNL3 | 26354 | RNAseq | -0.3541 | 0.5239 | |
| TCGA | GNL3 | 26354 | RNAseq | 0.0097 | 0.8461 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GNL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNL3 | 26354 | 0 | 18 | 12 | |
| GSE20123 | GNL3 | 26354 | 0 | 19 | 11 | |
| GSE43470 | GNL3 | 26354 | 0 | 18 | 25 | |
| GSE46452 | GNL3 | 26354 | 2 | 17 | 40 | |
| GSE47630 | GNL3 | 26354 | 1 | 24 | 15 | |
| GSE54993 | GNL3 | 26354 | 6 | 2 | 62 | |
| GSE54994 | GNL3 | 26354 | 0 | 33 | 20 | |
| GSE60625 | GNL3 | 26354 | 5 | 0 | 6 | |
| GSE74703 | GNL3 | 26354 | 0 | 14 | 22 | |
| GSE74704 | GNL3 | 26354 | 0 | 12 | 8 | |
| TCGA | GNL3 | 26354 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 235; Total Number of normals: 239.
Somatic mutations of GNL3:
Generating mutation plots.
Highly correlated genes for GNL3:
Showing top 20/754 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNL3 | SLC25A40 | 0.797925 | 3 | 0 | 3 |
| GNL3 | HCCS | 0.792096 | 3 | 0 | 3 |
| GNL3 | WDR77 | 0.775871 | 3 | 0 | 3 |
| GNL3 | XPO4 | 0.773184 | 3 | 0 | 3 |
| GNL3 | AP1M2 | 0.759337 | 3 | 0 | 3 |
| GNL3 | BDH2 | 0.754976 | 3 | 0 | 3 |
| GNL3 | RFNG | 0.753746 | 3 | 0 | 3 |
| GNL3 | ARHGEF6 | 0.751866 | 3 | 0 | 3 |
| GNL3 | TNFSF15 | 0.750393 | 3 | 0 | 3 |
| GNL3 | ZCCHC8 | 0.747036 | 3 | 0 | 3 |
| GNL3 | ACVR1B | 0.746414 | 4 | 0 | 3 |
| GNL3 | ZNF436 | 0.744425 | 5 | 0 | 5 |
| GNL3 | ZFP37 | 0.743839 | 3 | 0 | 3 |
| GNL3 | GYPC | 0.732773 | 3 | 0 | 3 |
| GNL3 | RPGR | 0.729486 | 3 | 0 | 3 |
| GNL3 | ANKRD13C | 0.723752 | 3 | 0 | 3 |
| GNL3 | HMGCS1 | 0.718333 | 4 | 0 | 4 |
| GNL3 | ZNF304 | 0.716586 | 5 | 0 | 5 |
| GNL3 | CA13 | 0.714824 | 3 | 0 | 3 |
| GNL3 | ZNF528 | 0.712292 | 3 | 0 | 3 |
For details and further investigation, click here
