| Full name: delta like canonical Notch ligand 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q27 | ||
| Entrez ID: 28514 | HGNC ID: HGNC:2908 | Ensembl Gene: ENSG00000198719 | OMIM ID: 606582 |
| Drug and gene relationship at DGIdb | |||
DLL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of DLL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLL1 | 28514 | 224215_s_at | -1.1620 | 0.1625 | |
| GSE26886 | DLL1 | 28514 | 224215_s_at | 0.4631 | 0.2445 | |
| GSE45670 | DLL1 | 28514 | 224215_s_at | -0.5444 | 0.1426 | |
| GSE63941 | DLL1 | 28514 | 224215_s_at | 1.3296 | 0.2634 | |
| GSE77861 | DLL1 | 28514 | 224215_s_at | -1.0037 | 0.0057 | |
| GSE97050 | DLL1 | 28514 | A_23_P167920 | 0.1572 | 0.7344 | |
| SRP007169 | DLL1 | 28514 | RNAseq | -0.9088 | 0.1600 | |
| SRP008496 | DLL1 | 28514 | RNAseq | -0.8867 | 0.0441 | |
| SRP064894 | DLL1 | 28514 | RNAseq | -0.4808 | 0.1339 | |
| SRP133303 | DLL1 | 28514 | RNAseq | -0.6340 | 0.0248 | |
| SRP159526 | DLL1 | 28514 | RNAseq | -1.1182 | 0.0000 | |
| SRP193095 | DLL1 | 28514 | RNAseq | 0.0152 | 0.9447 | |
| SRP219564 | DLL1 | 28514 | RNAseq | -1.2917 | 0.0333 | |
| TCGA | DLL1 | 28514 | RNAseq | 0.1924 | 0.1028 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by DLL1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DLL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLL1 | 28514 | 4 | 6 | 20 | |
| GSE20123 | DLL1 | 28514 | 4 | 6 | 20 | |
| GSE43470 | DLL1 | 28514 | 2 | 0 | 41 | |
| GSE46452 | DLL1 | 28514 | 3 | 10 | 46 | |
| GSE47630 | DLL1 | 28514 | 7 | 7 | 26 | |
| GSE54993 | DLL1 | 28514 | 4 | 3 | 63 | |
| GSE54994 | DLL1 | 28514 | 10 | 8 | 35 | |
| GSE60625 | DLL1 | 28514 | 1 | 1 | 9 | |
| GSE74703 | DLL1 | 28514 | 2 | 0 | 34 | |
| GSE74704 | DLL1 | 28514 | 2 | 3 | 15 | |
| TCGA | DLL1 | 28514 | 14 | 20 | 62 |
Total number of gains: 53; Total number of losses: 64; Total Number of normals: 371.
Somatic mutations of DLL1:
Generating mutation plots.
Highly correlated genes for DLL1:
Showing top 20/169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLL1 | LPAR6 | 0.78709 | 3 | 0 | 3 |
| DLL1 | SLC22A15 | 0.784493 | 3 | 0 | 3 |
| DLL1 | SLC16A6 | 0.756786 | 3 | 0 | 3 |
| DLL1 | SLC30A4 | 0.755279 | 3 | 0 | 3 |
| DLL1 | ZSWIM6 | 0.750092 | 3 | 0 | 3 |
| DLL1 | NLRP1 | 0.738206 | 3 | 0 | 3 |
| DLL1 | CPA4 | 0.729801 | 3 | 0 | 3 |
| DLL1 | ACVR1B | 0.725183 | 3 | 0 | 3 |
| DLL1 | CDC16 | 0.723189 | 3 | 0 | 3 |
| DLL1 | SETD4 | 0.721443 | 3 | 0 | 3 |
| DLL1 | PGM1 | 0.720008 | 3 | 0 | 3 |
| DLL1 | NHLH2 | 0.71921 | 3 | 0 | 3 |
| DLL1 | FAM114A2 | 0.718191 | 3 | 0 | 3 |
| DLL1 | COBLL1 | 0.714829 | 3 | 0 | 3 |
| DLL1 | FAM174A | 0.714061 | 3 | 0 | 3 |
| DLL1 | FBXL17 | 0.713162 | 3 | 0 | 3 |
| DLL1 | CHMP2B | 0.712006 | 3 | 0 | 3 |
| DLL1 | RFK | 0.704496 | 3 | 0 | 3 |
| DLL1 | CIDEB | 0.701361 | 3 | 0 | 3 |
| DLL1 | INPP1 | 0.700424 | 3 | 0 | 3 |
For details and further investigation, click here
