| Full name: protein phosphatase 1 regulatory inhibitor subunit 11 | Alias Symbol: HCGV|Tctex5|HCG-V|CFAP255 | ||
| Type: protein-coding gene | Cytoband: 6p22.1 | ||
| Entrez ID: 6992 | HGNC ID: HGNC:9285 | Ensembl Gene: ENSG00000204619 | OMIM ID: 606670 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPP1R11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R11 | 6992 | 201500_s_at | -0.2520 | 0.5851 | |
| GSE20347 | PPP1R11 | 6992 | 201500_s_at | -0.3824 | 0.0033 | |
| GSE23400 | PPP1R11 | 6992 | 201500_s_at | -0.1190 | 0.0069 | |
| GSE26886 | PPP1R11 | 6992 | 201500_s_at | -0.1196 | 0.6930 | |
| GSE29001 | PPP1R11 | 6992 | 201500_s_at | -0.2352 | 0.2099 | |
| GSE38129 | PPP1R11 | 6992 | 201500_s_at | -0.3253 | 0.0019 | |
| GSE45670 | PPP1R11 | 6992 | 201500_s_at | 0.1265 | 0.3802 | |
| GSE53622 | PPP1R11 | 6992 | 166602 | -0.0761 | 0.1516 | |
| GSE53624 | PPP1R11 | 6992 | 166602 | -0.6911 | 0.0000 | |
| GSE63941 | PPP1R11 | 6992 | 201500_s_at | 0.1208 | 0.7528 | |
| GSE77861 | PPP1R11 | 6992 | 201500_s_at | -0.3659 | 0.1313 | |
| GSE97050 | PPP1R11 | 6992 | A_33_P3474328 | -0.0228 | 0.9351 | |
| SRP007169 | PPP1R11 | 6992 | RNAseq | -0.9063 | 0.0078 | |
| SRP008496 | PPP1R11 | 6992 | RNAseq | -0.8858 | 0.0001 | |
| SRP064894 | PPP1R11 | 6992 | RNAseq | -0.0131 | 0.9293 | |
| SRP133303 | PPP1R11 | 6992 | RNAseq | -0.0435 | 0.7278 | |
| SRP159526 | PPP1R11 | 6992 | RNAseq | -0.2750 | 0.1911 | |
| SRP193095 | PPP1R11 | 6992 | RNAseq | -0.2582 | 0.0544 | |
| SRP219564 | PPP1R11 | 6992 | RNAseq | -0.0913 | 0.7579 | |
| TCGA | PPP1R11 | 6992 | RNAseq | -0.0592 | 0.2084 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP1R11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R11 | 6992 | 3 | 1 | 26 | |
| GSE20123 | PPP1R11 | 6992 | 3 | 1 | 26 | |
| GSE43470 | PPP1R11 | 6992 | 5 | 0 | 38 | |
| GSE46452 | PPP1R11 | 6992 | 1 | 10 | 48 | |
| GSE47630 | PPP1R11 | 6992 | 7 | 3 | 30 | |
| GSE54993 | PPP1R11 | 6992 | 2 | 1 | 67 | |
| GSE54994 | PPP1R11 | 6992 | 11 | 4 | 38 | |
| GSE60625 | PPP1R11 | 6992 | 0 | 1 | 10 | |
| GSE74703 | PPP1R11 | 6992 | 5 | 0 | 31 | |
| GSE74704 | PPP1R11 | 6992 | 1 | 0 | 19 | |
| TCGA | PPP1R11 | 6992 | 16 | 17 | 63 |
Total number of gains: 54; Total number of losses: 38; Total Number of normals: 396.
Somatic mutations of PPP1R11:
Generating mutation plots.
Highly correlated genes for PPP1R11:
Showing top 20/366 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R11 | ABHD14B | 0.82051 | 3 | 0 | 3 |
| PPP1R11 | TMCO4 | 0.808918 | 3 | 0 | 3 |
| PPP1R11 | PBX2 | 0.808462 | 3 | 0 | 3 |
| PPP1R11 | ZNF829 | 0.798938 | 3 | 0 | 3 |
| PPP1R11 | EIF2D | 0.778561 | 4 | 0 | 4 |
| PPP1R11 | MPND | 0.763967 | 3 | 0 | 3 |
| PPP1R11 | TMEM219 | 0.755269 | 3 | 0 | 3 |
| PPP1R11 | RPL18 | 0.749692 | 3 | 0 | 3 |
| PPP1R11 | KIAA2026 | 0.745928 | 3 | 0 | 3 |
| PPP1R11 | ABCG2 | 0.742279 | 3 | 0 | 3 |
| PPP1R11 | HDHD2 | 0.738674 | 3 | 0 | 3 |
| PPP1R11 | TAF9B | 0.734819 | 3 | 0 | 3 |
| PPP1R11 | C17orf97 | 0.731825 | 3 | 0 | 3 |
| PPP1R11 | ARFIP1 | 0.726949 | 3 | 0 | 3 |
| PPP1R11 | ZNF256 | 0.726069 | 3 | 0 | 3 |
| PPP1R11 | ACVR1B | 0.72593 | 3 | 0 | 3 |
| PPP1R11 | PGGT1B | 0.725343 | 3 | 0 | 3 |
| PPP1R11 | ALKBH7 | 0.724032 | 3 | 0 | 3 |
| PPP1R11 | MBNL3 | 0.717464 | 4 | 0 | 4 |
| PPP1R11 | TMEM120A | 0.711626 | 3 | 0 | 3 |
For details and further investigation, click here
