| Full name: caspase 9 | Alias Symbol: MCH6|ICE-LAP6|APAF-3|PPP1R56 | ||
| Type: protein-coding gene | Cytoband: 1p36.21 | ||
| Entrez ID: 842 | HGNC ID: HGNC:1511 | Ensembl Gene: ENSG00000132906 | OMIM ID: 602234 |
| Drug and gene relationship at DGIdb | |||
CASP9 involved pathways:
Expression of CASP9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASP9 | 842 | 203984_s_at | -0.0672 | 0.8634 | |
| GSE20347 | CASP9 | 842 | 203984_s_at | -0.3417 | 0.0138 | |
| GSE23400 | CASP9 | 842 | 210775_x_at | -0.1772 | 0.0000 | |
| GSE26886 | CASP9 | 842 | 203984_s_at | -0.2453 | 0.1803 | |
| GSE29001 | CASP9 | 842 | 203984_s_at | -0.4028 | 0.0929 | |
| GSE38129 | CASP9 | 842 | 203984_s_at | -0.3386 | 0.0104 | |
| GSE45670 | CASP9 | 842 | 203984_s_at | 0.0191 | 0.9293 | |
| GSE53622 | CASP9 | 842 | 58518 | -0.3649 | 0.0000 | |
| GSE53624 | CASP9 | 842 | 58518 | -0.4364 | 0.0000 | |
| GSE63941 | CASP9 | 842 | 203984_s_at | -0.3371 | 0.2917 | |
| GSE77861 | CASP9 | 842 | 203984_s_at | -0.4179 | 0.0377 | |
| GSE97050 | CASP9 | 842 | A_23_P97309 | -0.1269 | 0.6629 | |
| SRP007169 | CASP9 | 842 | RNAseq | -1.7197 | 0.0000 | |
| SRP008496 | CASP9 | 842 | RNAseq | -1.4812 | 0.0000 | |
| SRP064894 | CASP9 | 842 | RNAseq | -0.5014 | 0.0065 | |
| SRP133303 | CASP9 | 842 | RNAseq | -0.1871 | 0.1593 | |
| SRP159526 | CASP9 | 842 | RNAseq | -0.4732 | 0.0250 | |
| SRP193095 | CASP9 | 842 | RNAseq | -0.3068 | 0.0218 | |
| SRP219564 | CASP9 | 842 | RNAseq | -0.0645 | 0.8743 | |
| TCGA | CASP9 | 842 | RNAseq | -0.1890 | 0.0093 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CASP9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASP9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASP9 | 842 | 1 | 5 | 24 | |
| GSE20123 | CASP9 | 842 | 1 | 4 | 25 | |
| GSE43470 | CASP9 | 842 | 1 | 8 | 34 | |
| GSE46452 | CASP9 | 842 | 7 | 1 | 51 | |
| GSE47630 | CASP9 | 842 | 8 | 3 | 29 | |
| GSE54993 | CASP9 | 842 | 3 | 1 | 66 | |
| GSE54994 | CASP9 | 842 | 10 | 4 | 39 | |
| GSE60625 | CASP9 | 842 | 0 | 0 | 11 | |
| GSE74703 | CASP9 | 842 | 1 | 5 | 30 | |
| GSE74704 | CASP9 | 842 | 1 | 0 | 19 | |
| TCGA | CASP9 | 842 | 11 | 23 | 62 |
Total number of gains: 44; Total number of losses: 54; Total Number of normals: 390.
Somatic mutations of CASP9:
Generating mutation plots.
Highly correlated genes for CASP9:
Showing top 20/384 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASP9 | SLC44A4 | 0.805171 | 3 | 0 | 3 |
| CASP9 | HIC2 | 0.795604 | 3 | 0 | 3 |
| CASP9 | ZNF578 | 0.794519 | 3 | 0 | 3 |
| CASP9 | LYRM1 | 0.757809 | 3 | 0 | 3 |
| CASP9 | ABHD6 | 0.746122 | 3 | 0 | 3 |
| CASP9 | UXT | 0.734822 | 3 | 0 | 3 |
| CASP9 | ACVR1B | 0.731736 | 4 | 0 | 4 |
| CASP9 | ZNF627 | 0.725668 | 3 | 0 | 3 |
| CASP9 | NFXL1 | 0.724885 | 3 | 0 | 3 |
| CASP9 | ZNF436 | 0.711928 | 4 | 0 | 3 |
| CASP9 | SCMH1 | 0.710744 | 3 | 0 | 3 |
| CASP9 | MAN2B2 | 0.70263 | 4 | 0 | 4 |
| CASP9 | ADCK1 | 0.695988 | 3 | 0 | 3 |
| CASP9 | ZNF41 | 0.69587 | 3 | 0 | 3 |
| CASP9 | ZNF143 | 0.693492 | 3 | 0 | 3 |
| CASP9 | ZNF717 | 0.693151 | 5 | 0 | 5 |
| CASP9 | CHCHD1 | 0.679449 | 4 | 0 | 3 |
| CASP9 | BBIP1 | 0.677241 | 3 | 0 | 3 |
| CASP9 | TXLNG | 0.67522 | 4 | 0 | 3 |
| CASP9 | TBL1X | 0.673579 | 3 | 0 | 3 |
For details and further investigation, click here
