GNG5

 

Full name: G protein subunit gamma 5 Alias Symbol: 
Type: protein-coding gene Cytoband: 1p22.3
Entrez ID: 2787 HGNC ID: HGNC:4408 Ensembl Gene: ENSG00000174021 OMIM ID: 600874
Drug and gene relationship at DGIdb
Screen Evidence:

 

GNG5 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNG5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNG5 2787 207157_s_at -0.1800 0.4665
GSE20347 GNG5 2787 207157_s_at -0.6720 0.0001
GSE23400 GNG5 2787 207157_s_at -0.2384 0.0002
GSE26886 GNG5 2787 207157_s_at 0.0294 0.9139
GSE29001 GNG5 2787 207157_s_at -0.4828 0.0158
GSE38129 GNG5 2787 207157_s_at -0.3935 0.0034
GSE45670 GNG5 2787 207157_s_at -0.0294 0.8551
GSE53622 GNG5 2787 53900 -0.0976 0.1586
GSE53624 GNG5 2787 53900 -0.1832 0.0020
GSE63941 GNG5 2787 207157_s_at -0.1430 0.7276
GSE77861 GNG5 2787 207157_s_at -0.6795 0.0011
GSE97050 GNG5 2787 A_23_P148513 0.0881 0.7641
SRP007169 GNG5 2787 RNAseq -1.0106 0.0062
SRP008496 GNG5 2787 RNAseq -0.9241 0.0000
SRP064894 GNG5 2787 RNAseq 0.0644 0.8014
SRP133303 GNG5 2787 RNAseq -0.0823 0.5702
SRP159526 GNG5 2787 RNAseq -0.7701 0.0002
SRP193095 GNG5 2787 RNAseq -0.7095 0.0000
SRP219564 GNG5 2787 RNAseq 0.0559 0.8663
TCGA GNG5 2787 RNAseq -0.0420 0.4019

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by GNG5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNG5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNG5 2787 0 8 22
GSE20123 GNG5 2787 0 8 22
GSE43470 GNG5 2787 2 2 39
GSE46452 GNG5 2787 0 1 58
GSE47630 GNG5 2787 8 5 27
GSE54993 GNG5 2787 0 0 70
GSE54994 GNG5 2787 6 3 44
GSE60625 GNG5 2787 0 0 11
GSE74703 GNG5 2787 1 2 33
GSE74704 GNG5 2787 0 5 15
TCGA GNG5 2787 7 23 66

Total number of gains: 24; Total number of losses: 57; Total Number of normals: 407.  

 

Somatic mutations of GNG5:

 

Generating mutation plots.

 

Highly correlated genes for GNG5:

 

Showing top 20/884 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNG5FBXO100.82079303
GNG5C2orf160.813956303
GNG5HECW20.798941303
GNG5COPE0.789964303
GNG5SVIP0.759259303
GNG5CDC160.753331303
GNG5ZNF2140.752986303
GNG5GYPC0.740835303
GNG5PRELID10.734245303
GNG5TMEM161B0.73152303
GNG5TIMM230.72911303
GNG5OAT0.724387303
GNG5ACVR1B0.722206403
GNG5EPB410.721142403
GNG5CABLES10.716997303
GNG5CGGBP10.715358303
GNG5RALGPS20.714571403
GNG5ZDHHC210.7108303
GNG5TBC1D22B0.701408404
GNG5MRPS310.699682303

For details and further investigation, click here