| Full name: lysosomal protein transmembrane 4 alpha | Alias Symbol: HUMORF13|KIAA0108|Mtrp|LAPTM4 | ||
| Type: protein-coding gene | Cytoband: 2p24.1 | ||
| Entrez ID: 9741 | HGNC ID: HGNC:6924 | Ensembl Gene: ENSG00000068697 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of LAPTM4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAPTM4A | 9741 | 200673_at | -0.1163 | 0.7709 | |
| GSE20347 | LAPTM4A | 9741 | 200673_at | -0.2778 | 0.0167 | |
| GSE23400 | LAPTM4A | 9741 | 200673_at | -0.1282 | 0.0176 | |
| GSE26886 | LAPTM4A | 9741 | 200673_at | -0.7583 | 0.0000 | |
| GSE29001 | LAPTM4A | 9741 | 200673_at | -0.1375 | 0.6592 | |
| GSE38129 | LAPTM4A | 9741 | 200673_at | -0.2222 | 0.0713 | |
| GSE45670 | LAPTM4A | 9741 | 200673_at | -0.1235 | 0.2468 | |
| GSE53622 | LAPTM4A | 9741 | 57640 | -0.3340 | 0.0000 | |
| GSE53624 | LAPTM4A | 9741 | 57640 | -0.2435 | 0.0000 | |
| GSE63941 | LAPTM4A | 9741 | 200673_at | -1.0533 | 0.0033 | |
| GSE77861 | LAPTM4A | 9741 | 200673_at | -0.1972 | 0.2667 | |
| GSE97050 | LAPTM4A | 9741 | A_23_P90659 | -0.1800 | 0.3522 | |
| SRP007169 | LAPTM4A | 9741 | RNAseq | -1.4889 | 0.0000 | |
| SRP008496 | LAPTM4A | 9741 | RNAseq | -1.1263 | 0.0000 | |
| SRP064894 | LAPTM4A | 9741 | RNAseq | -0.1197 | 0.4178 | |
| SRP133303 | LAPTM4A | 9741 | RNAseq | -0.0365 | 0.8102 | |
| SRP159526 | LAPTM4A | 9741 | RNAseq | 0.0057 | 0.9743 | |
| SRP193095 | LAPTM4A | 9741 | RNAseq | -0.4749 | 0.0012 | |
| SRP219564 | LAPTM4A | 9741 | RNAseq | -0.0911 | 0.7657 | |
| TCGA | LAPTM4A | 9741 | RNAseq | -0.0460 | 0.2249 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by LAPTM4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAPTM4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAPTM4A | 9741 | 9 | 2 | 19 | |
| GSE20123 | LAPTM4A | 9741 | 9 | 2 | 19 | |
| GSE43470 | LAPTM4A | 9741 | 2 | 0 | 41 | |
| GSE46452 | LAPTM4A | 9741 | 3 | 4 | 52 | |
| GSE47630 | LAPTM4A | 9741 | 7 | 0 | 33 | |
| GSE54993 | LAPTM4A | 9741 | 0 | 7 | 63 | |
| GSE54994 | LAPTM4A | 9741 | 11 | 0 | 42 | |
| GSE60625 | LAPTM4A | 9741 | 0 | 3 | 8 | |
| GSE74703 | LAPTM4A | 9741 | 2 | 0 | 34 | |
| GSE74704 | LAPTM4A | 9741 | 8 | 2 | 10 | |
| TCGA | LAPTM4A | 9741 | 37 | 2 | 57 |
Total number of gains: 88; Total number of losses: 22; Total Number of normals: 378.
Somatic mutations of LAPTM4A:
Generating mutation plots.
Highly correlated genes for LAPTM4A:
Showing top 20/703 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAPTM4A | SYTL4 | 0.787672 | 3 | 0 | 3 |
| LAPTM4A | FYTTD1 | 0.783814 | 3 | 0 | 3 |
| LAPTM4A | NDUFA10 | 0.778884 | 5 | 0 | 5 |
| LAPTM4A | BLOC1S2 | 0.767377 | 3 | 0 | 3 |
| LAPTM4A | COPS2 | 0.766926 | 4 | 0 | 4 |
| LAPTM4A | PGK1 | 0.764673 | 3 | 0 | 3 |
| LAPTM4A | C3orf38 | 0.76345 | 3 | 0 | 3 |
| LAPTM4A | MTMR3 | 0.753944 | 4 | 0 | 4 |
| LAPTM4A | MKKS | 0.750413 | 3 | 0 | 3 |
| LAPTM4A | PSMC6 | 0.742209 | 3 | 0 | 3 |
| LAPTM4A | CIB1 | 0.741097 | 3 | 0 | 3 |
| LAPTM4A | SCARB2 | 0.731569 | 3 | 0 | 3 |
| LAPTM4A | AKIRIN1 | 0.727171 | 3 | 0 | 3 |
| LAPTM4A | SLC10A7 | 0.72081 | 3 | 0 | 3 |
| LAPTM4A | PKN2 | 0.719434 | 4 | 0 | 4 |
| LAPTM4A | AK3 | 0.718241 | 4 | 0 | 3 |
| LAPTM4A | ACVR1B | 0.717475 | 3 | 0 | 3 |
| LAPTM4A | MSRB3 | 0.714904 | 3 | 0 | 3 |
| LAPTM4A | LARP4 | 0.714266 | 3 | 0 | 3 |
| LAPTM4A | NGLY1 | 0.709069 | 3 | 0 | 3 |
For details and further investigation, click here
