| Full name: SPRY domain containing 4 | Alias Symbol: DKFZp686N0877 | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 283377 | HGNC ID: HGNC:27468 | Ensembl Gene: ENSG00000176422 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of SPRYD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPRYD4 | 283377 | 225616_at | -0.3630 | 0.3140 | |
| GSE26886 | SPRYD4 | 283377 | 225616_at | -0.7418 | 0.0034 | |
| GSE45670 | SPRYD4 | 283377 | 225616_at | 0.0867 | 0.5757 | |
| GSE53622 | SPRYD4 | 283377 | 42686 | -0.3817 | 0.0016 | |
| GSE53624 | SPRYD4 | 283377 | 42686 | 0.0538 | 0.5354 | |
| GSE63941 | SPRYD4 | 283377 | 225616_at | 1.4303 | 0.0004 | |
| GSE77861 | SPRYD4 | 283377 | 225616_at | -0.3581 | 0.0401 | |
| GSE97050 | SPRYD4 | 283377 | A_23_P411612 | 0.0021 | 0.9939 | |
| SRP007169 | SPRYD4 | 283377 | RNAseq | -0.4816 | 0.3058 | |
| SRP008496 | SPRYD4 | 283377 | RNAseq | -0.4195 | 0.1296 | |
| SRP064894 | SPRYD4 | 283377 | RNAseq | -0.2512 | 0.0736 | |
| SRP133303 | SPRYD4 | 283377 | RNAseq | -0.1686 | 0.2798 | |
| SRP159526 | SPRYD4 | 283377 | RNAseq | -0.4127 | 0.0492 | |
| SRP193095 | SPRYD4 | 283377 | RNAseq | -0.2351 | 0.0119 | |
| SRP219564 | SPRYD4 | 283377 | RNAseq | -0.4251 | 0.2512 | |
| TCGA | SPRYD4 | 283377 | RNAseq | 0.1130 | 0.0944 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SPRYD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPRYD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPRYD4 | 283377 | 7 | 2 | 21 | |
| GSE20123 | SPRYD4 | 283377 | 7 | 1 | 22 | |
| GSE43470 | SPRYD4 | 283377 | 3 | 0 | 40 | |
| GSE46452 | SPRYD4 | 283377 | 8 | 1 | 50 | |
| GSE47630 | SPRYD4 | 283377 | 10 | 2 | 28 | |
| GSE54993 | SPRYD4 | 283377 | 0 | 5 | 65 | |
| GSE54994 | SPRYD4 | 283377 | 4 | 1 | 48 | |
| GSE60625 | SPRYD4 | 283377 | 0 | 0 | 11 | |
| GSE74703 | SPRYD4 | 283377 | 3 | 0 | 33 | |
| GSE74704 | SPRYD4 | 283377 | 4 | 1 | 15 | |
| TCGA | SPRYD4 | 283377 | 14 | 10 | 72 |
Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.
Somatic mutations of SPRYD4:
Generating mutation plots.
Highly correlated genes for SPRYD4:
Showing top 20/807 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPRYD4 | POLE3 | 0.827588 | 3 | 0 | 3 |
| SPRYD4 | RASAL2 | 0.810618 | 3 | 0 | 3 |
| SPRYD4 | QRICH1 | 0.783349 | 4 | 0 | 4 |
| SPRYD4 | UGP2 | 0.767223 | 3 | 0 | 3 |
| SPRYD4 | C1orf56 | 0.762554 | 3 | 0 | 3 |
| SPRYD4 | SLC35D2 | 0.761101 | 3 | 0 | 3 |
| SPRYD4 | MEAF6 | 0.759194 | 3 | 0 | 3 |
| SPRYD4 | RUFY1 | 0.752729 | 4 | 0 | 3 |
| SPRYD4 | RPS14 | 0.752517 | 3 | 0 | 3 |
| SPRYD4 | MCCC2 | 0.749739 | 3 | 0 | 3 |
| SPRYD4 | TRAPPC1 | 0.748112 | 3 | 0 | 3 |
| SPRYD4 | TP53RK | 0.74805 | 3 | 0 | 3 |
| SPRYD4 | DENND4C | 0.747799 | 3 | 0 | 3 |
| SPRYD4 | ZNF747 | 0.746396 | 3 | 0 | 3 |
| SPRYD4 | NCOA1 | 0.743514 | 3 | 0 | 3 |
| SPRYD4 | LEPROT | 0.741526 | 3 | 0 | 3 |
| SPRYD4 | YPEL3 | 0.74094 | 3 | 0 | 3 |
| SPRYD4 | PDCD6IP | 0.739857 | 4 | 0 | 4 |
| SPRYD4 | MBNL3 | 0.735971 | 4 | 0 | 3 |
| SPRYD4 | COPZ1 | 0.735881 | 6 | 0 | 6 |
For details and further investigation, click here
