| Full name: poly(ADP-ribose) glycohydrolase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q11.23 | ||
| Entrez ID: 8505 | HGNC ID: HGNC:8605 | Ensembl Gene: ENSG00000227345 | OMIM ID: 603501 |
| Drug and gene relationship at DGIdb | |||
Expression of PARG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARG | 8505 | 205060_at | 0.1485 | 0.8064 | |
| GSE20347 | PARG | 8505 | 205060_at | 0.1166 | 0.2399 | |
| GSE23400 | PARG | 8505 | 205060_at | 0.0943 | 0.0341 | |
| GSE26886 | PARG | 8505 | 205060_at | -0.3058 | 0.0277 | |
| GSE29001 | PARG | 8505 | 205060_at | 0.0312 | 0.8856 | |
| GSE38129 | PARG | 8505 | 205060_at | 0.1750 | 0.0234 | |
| GSE45670 | PARG | 8505 | 205060_at | 0.0572 | 0.6301 | |
| GSE63941 | PARG | 8505 | 205060_at | -0.1073 | 0.8031 | |
| GSE77861 | PARG | 8505 | 205060_at | -0.0256 | 0.9018 | |
| GSE97050 | PARG | 8505 | A_33_P3314212 | 0.0358 | 0.9001 | |
| SRP007169 | PARG | 8505 | RNAseq | 0.2909 | 0.4877 | |
| SRP008496 | PARG | 8505 | RNAseq | 1.0625 | 0.0098 | |
| SRP064894 | PARG | 8505 | RNAseq | -0.1014 | 0.5170 | |
| SRP133303 | PARG | 8505 | RNAseq | 0.1883 | 0.0412 | |
| SRP159526 | PARG | 8505 | RNAseq | -0.0606 | 0.8198 | |
| SRP193095 | PARG | 8505 | RNAseq | -0.1459 | 0.0490 | |
| SRP219564 | PARG | 8505 | RNAseq | -0.1813 | 0.4074 | |
| TCGA | PARG | 8505 | RNAseq | 0.0351 | 0.5234 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PARG expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PARG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARG | 8505 | 2 | 5 | 23 | |
| GSE20123 | PARG | 8505 | 2 | 5 | 23 | |
| GSE43470 | PARG | 8505 | 2 | 6 | 35 | |
| GSE46452 | PARG | 8505 | 0 | 13 | 46 | |
| GSE47630 | PARG | 8505 | 4 | 12 | 24 | |
| GSE54993 | PARG | 8505 | 9 | 0 | 61 | |
| GSE54994 | PARG | 8505 | 2 | 10 | 41 | |
| GSE60625 | PARG | 8505 | 0 | 0 | 11 | |
| GSE74703 | PARG | 8505 | 2 | 3 | 31 | |
| GSE74704 | PARG | 8505 | 1 | 4 | 15 | |
| TCGA | PARG | 8505 | 13 | 22 | 61 |
Total number of gains: 37; Total number of losses: 80; Total Number of normals: 371.
Somatic mutations of PARG:
Generating mutation plots.
Highly correlated genes for PARG:
Showing top 20/365 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARG | RPP38 | 0.860167 | 3 | 0 | 3 |
| PARG | LPCAT3 | 0.832366 | 3 | 0 | 3 |
| PARG | UBE2L3 | 0.805678 | 3 | 0 | 3 |
| PARG | ZFX | 0.805641 | 3 | 0 | 3 |
| PARG | CMTM6 | 0.802054 | 3 | 0 | 3 |
| PARG | SLC25A40 | 0.800384 | 3 | 0 | 3 |
| PARG | ZNF518A | 0.798976 | 3 | 0 | 3 |
| PARG | ZBTB1 | 0.791681 | 3 | 0 | 3 |
| PARG | MRPL51 | 0.784447 | 3 | 0 | 3 |
| PARG | ZNF616 | 0.775367 | 3 | 0 | 3 |
| PARG | PPM1A | 0.762321 | 3 | 0 | 3 |
| PARG | ZNF480 | 0.761965 | 3 | 0 | 3 |
| PARG | ACSS2 | 0.760756 | 3 | 0 | 3 |
| PARG | UNC5CL | 0.759767 | 3 | 0 | 3 |
| PARG | WDFY1 | 0.757822 | 3 | 0 | 3 |
| PARG | POLA1 | 0.756863 | 4 | 0 | 4 |
| PARG | KBTBD4 | 0.746863 | 3 | 0 | 3 |
| PARG | CWF19L1 | 0.738052 | 3 | 0 | 3 |
| PARG | TRMT61B | 0.736683 | 3 | 0 | 3 |
| PARG | EPS15 | 0.736469 | 3 | 0 | 3 |
For details and further investigation, click here
