| Full name: activin A receptor type 2B | Alias Symbol: ActR-IIB | ||
| Type: protein-coding gene | Cytoband: 3p22.2 | ||
| Entrez ID: 93 | HGNC ID: HGNC:174 | Ensembl Gene: ENSG00000114739 | OMIM ID: 602730 |
| Drug and gene relationship at DGIdb | |||
ACVR2B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of ACVR2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACVR2B | 93 | 236126_at | 0.3462 | 0.4436 | |
| GSE20347 | ACVR2B | 93 | 220028_at | 0.2273 | 0.0041 | |
| GSE23400 | ACVR2B | 93 | 220028_at | -0.0417 | 0.2889 | |
| GSE26886 | ACVR2B | 93 | 236126_at | 1.0797 | 0.0000 | |
| GSE29001 | ACVR2B | 93 | 220028_at | -0.0299 | 0.9074 | |
| GSE38129 | ACVR2B | 93 | 220028_at | 0.1842 | 0.0645 | |
| GSE45670 | ACVR2B | 93 | 236126_at | 0.1045 | 0.6612 | |
| GSE53622 | ACVR2B | 93 | 63302 | 0.1242 | 0.2873 | |
| GSE53624 | ACVR2B | 93 | 63302 | 0.2744 | 0.0011 | |
| GSE63941 | ACVR2B | 93 | 236126_at | 1.1306 | 0.0321 | |
| GSE77861 | ACVR2B | 93 | 236126_at | 0.1244 | 0.3038 | |
| GSE97050 | ACVR2B | 93 | A_32_P134209 | 0.0314 | 0.8926 | |
| SRP007169 | ACVR2B | 93 | RNAseq | 1.7356 | 0.0018 | |
| SRP008496 | ACVR2B | 93 | RNAseq | 1.3625 | 0.0012 | |
| SRP064894 | ACVR2B | 93 | RNAseq | 0.3487 | 0.0637 | |
| SRP133303 | ACVR2B | 93 | RNAseq | -0.1311 | 0.3885 | |
| SRP159526 | ACVR2B | 93 | RNAseq | 0.4964 | 0.1217 | |
| SRP193095 | ACVR2B | 93 | RNAseq | 0.2718 | 0.0634 | |
| SRP219564 | ACVR2B | 93 | RNAseq | 0.3512 | 0.4785 | |
| TCGA | ACVR2B | 93 | RNAseq | -0.1748 | 0.0327 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ACVR2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACVR2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACVR2B | 93 | 0 | 19 | 11 | |
| GSE20123 | ACVR2B | 93 | 0 | 19 | 11 | |
| GSE43470 | ACVR2B | 93 | 0 | 20 | 23 | |
| GSE46452 | ACVR2B | 93 | 2 | 17 | 40 | |
| GSE47630 | ACVR2B | 93 | 1 | 25 | 14 | |
| GSE54993 | ACVR2B | 93 | 6 | 3 | 61 | |
| GSE54994 | ACVR2B | 93 | 0 | 34 | 19 | |
| GSE60625 | ACVR2B | 93 | 5 | 0 | 6 | |
| GSE74703 | ACVR2B | 93 | 0 | 16 | 20 | |
| GSE74704 | ACVR2B | 93 | 0 | 13 | 7 | |
| TCGA | ACVR2B | 93 | 1 | 71 | 24 |
Total number of gains: 15; Total number of losses: 237; Total Number of normals: 236.
Somatic mutations of ACVR2B:
Generating mutation plots.
Highly correlated genes for ACVR2B:
Showing top 20/265 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACVR2B | PNMA6A | 0.794226 | 3 | 0 | 3 |
| ACVR2B | ASMTL | 0.772534 | 3 | 0 | 3 |
| ACVR2B | CPAMD8 | 0.754736 | 3 | 0 | 3 |
| ACVR2B | ARL8A | 0.739156 | 3 | 0 | 3 |
| ACVR2B | PMEPA1 | 0.726907 | 3 | 0 | 3 |
| ACVR2B | RELB | 0.720273 | 4 | 0 | 4 |
| ACVR2B | HSD17B14 | 0.711751 | 3 | 0 | 3 |
| ACVR2B | CNOT3 | 0.709481 | 3 | 0 | 3 |
| ACVR2B | LIME1 | 0.693546 | 3 | 0 | 3 |
| ACVR2B | NCR3 | 0.691346 | 3 | 0 | 3 |
| ACVR2B | DMP1 | 0.687726 | 3 | 0 | 3 |
| ACVR2B | ATP2B2 | 0.687665 | 5 | 0 | 4 |
| ACVR2B | PKLR | 0.686551 | 3 | 0 | 3 |
| ACVR2B | GPR180 | 0.686135 | 4 | 0 | 4 |
| ACVR2B | SYCE1L | 0.685118 | 4 | 0 | 3 |
| ACVR2B | ZMYND15 | 0.683541 | 4 | 0 | 4 |
| ACVR2B | ZNF511 | 0.679288 | 3 | 0 | 3 |
| ACVR2B | ORM1 | 0.678152 | 3 | 0 | 3 |
| ACVR2B | TOX2 | 0.67672 | 3 | 0 | 3 |
| ACVR2B | ZC3H10 | 0.674045 | 3 | 0 | 3 |
For details and further investigation, click here
