| Full name: hydroxysteroid 17-beta dehydrogenase 14 | Alias Symbol: retSDR3|SDR47C1 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 51171 | HGNC ID: HGNC:23238 | Ensembl Gene: ENSG00000087076 | OMIM ID: 612832 |
| Drug and gene relationship at DGIdb | |||
Expression of HSD17B14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B14 | 51171 | 228713_s_at | 0.0743 | 0.7721 | |
| GSE20347 | HSD17B14 | 51171 | 219113_x_at | 0.1586 | 0.0437 | |
| GSE23400 | HSD17B14 | 51171 | 219113_x_at | -0.0581 | 0.2336 | |
| GSE26886 | HSD17B14 | 51171 | 228713_s_at | 0.8220 | 0.0000 | |
| GSE29001 | HSD17B14 | 51171 | 219113_x_at | 0.1912 | 0.3262 | |
| GSE38129 | HSD17B14 | 51171 | 219113_x_at | 0.1885 | 0.0384 | |
| GSE45670 | HSD17B14 | 51171 | 219113_x_at | 0.0012 | 0.9942 | |
| GSE53622 | HSD17B14 | 51171 | 24556 | 0.1777 | 0.0102 | |
| GSE53624 | HSD17B14 | 51171 | 24556 | -0.0503 | 0.5418 | |
| GSE63941 | HSD17B14 | 51171 | 228713_s_at | 0.2034 | 0.6614 | |
| GSE77861 | HSD17B14 | 51171 | 219113_x_at | 0.1205 | 0.2612 | |
| GSE97050 | HSD17B14 | 51171 | A_23_P78762 | -0.0370 | 0.8735 | |
| SRP007169 | HSD17B14 | 51171 | RNAseq | 4.4280 | 0.0002 | |
| SRP064894 | HSD17B14 | 51171 | RNAseq | 0.2381 | 0.5243 | |
| SRP133303 | HSD17B14 | 51171 | RNAseq | 0.3083 | 0.2775 | |
| SRP159526 | HSD17B14 | 51171 | RNAseq | 0.4155 | 0.2313 | |
| SRP219564 | HSD17B14 | 51171 | RNAseq | 0.2433 | 0.6198 | |
| TCGA | HSD17B14 | 51171 | RNAseq | 0.1350 | 0.4971 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HSD17B14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B14 | 51171 | 4 | 4 | 22 | |
| GSE20123 | HSD17B14 | 51171 | 4 | 3 | 23 | |
| GSE43470 | HSD17B14 | 51171 | 4 | 10 | 29 | |
| GSE46452 | HSD17B14 | 51171 | 45 | 1 | 13 | |
| GSE47630 | HSD17B14 | 51171 | 9 | 6 | 25 | |
| GSE54993 | HSD17B14 | 51171 | 17 | 4 | 49 | |
| GSE54994 | HSD17B14 | 51171 | 4 | 14 | 35 | |
| GSE60625 | HSD17B14 | 51171 | 9 | 0 | 2 | |
| GSE74703 | HSD17B14 | 51171 | 4 | 7 | 25 | |
| GSE74704 | HSD17B14 | 51171 | 4 | 1 | 15 | |
| TCGA | HSD17B14 | 51171 | 14 | 18 | 64 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of HSD17B14:
Generating mutation plots.
Highly correlated genes for HSD17B14:
Showing top 20/266 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B14 | SHISA4 | 0.783742 | 3 | 0 | 3 |
| HSD17B14 | SHARPIN | 0.765431 | 4 | 0 | 4 |
| HSD17B14 | SHANK1 | 0.754445 | 3 | 0 | 3 |
| HSD17B14 | DCAF15 | 0.754214 | 3 | 0 | 3 |
| HSD17B14 | CYP11B1 | 0.753885 | 3 | 0 | 3 |
| HSD17B14 | NAT14 | 0.741229 | 3 | 0 | 3 |
| HSD17B14 | C19orf53 | 0.739319 | 3 | 0 | 3 |
| HSD17B14 | KAZALD1 | 0.732803 | 3 | 0 | 3 |
| HSD17B14 | NACAD | 0.732642 | 3 | 0 | 3 |
| HSD17B14 | SPATA2L | 0.730853 | 4 | 0 | 3 |
| HSD17B14 | PDE6C | 0.729466 | 3 | 0 | 3 |
| HSD17B14 | VAV2 | 0.721247 | 4 | 0 | 3 |
| HSD17B14 | B3GALT1 | 0.718772 | 3 | 0 | 3 |
| HSD17B14 | CEMP1 | 0.717016 | 3 | 0 | 3 |
| HSD17B14 | NPM2 | 0.7152 | 3 | 0 | 3 |
| HSD17B14 | ZNF205 | 0.713933 | 4 | 0 | 4 |
| HSD17B14 | MUC2 | 0.713908 | 3 | 0 | 3 |
| HSD17B14 | SDK1 | 0.711887 | 3 | 0 | 3 |
| HSD17B14 | ACVR2B | 0.711751 | 3 | 0 | 3 |
| HSD17B14 | CHD5 | 0.708307 | 3 | 0 | 3 |
For details and further investigation, click here
