ATP2B2

 

Full name: ATPase plasma membrane Ca2+ transporting 2 Alias Symbol: PMCA2
Type: protein-coding gene Cytoband: 3p25.3
Entrez ID: 491 HGNC ID: HGNC:815 Ensembl Gene: ENSG00000157087 OMIM ID: 108733
Drug and gene relationship at DGIdb

 

ATP2B2 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes

 

Expression of ATP2B2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ATP2B2 491 204685_s_at 0.2595 0.5452
GSE20347 ATP2B2 491 204685_s_at 0.0477 0.4744
GSE23400 ATP2B2 491 204685_s_at -0.1267 0.0037
GSE26886 ATP2B2 491 234714_x_at 0.1781 0.1735
GSE29001 ATP2B2 491 204685_s_at -0.0306 0.9328
GSE38129 ATP2B2 491 204685_s_at -0.1061 0.1530
GSE45670 ATP2B2 491 234714_x_at -0.0973 0.3219
GSE53622 ATP2B2 491 75332 -0.1059 0.1977
GSE53624 ATP2B2 491 75332 0.0977 0.4532
GSE63941 ATP2B2 491 234714_x_at 0.1191 0.4193
GSE77861 ATP2B2 491 234714_x_at -0.0422 0.7718
GSE97050 ATP2B2 491 A_23_P18152 -0.1348 0.6994
SRP133303 ATP2B2 491 RNAseq -0.9114 0.0621
SRP159526 ATP2B2 491 RNAseq -1.9402 0.0112
TCGA ATP2B2 491 RNAseq -1.1254 0.0496

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by ATP2B2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ATP2B2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ATP2B2 491 1 18 11
GSE20123 ATP2B2 491 1 18 11
GSE43470 ATP2B2 491 1 20 22
GSE46452 ATP2B2 491 2 17 40
GSE47630 ATP2B2 491 2 23 15
GSE54993 ATP2B2 491 6 1 63
GSE54994 ATP2B2 491 3 31 19
GSE60625 ATP2B2 491 5 0 6
GSE74703 ATP2B2 491 1 16 19
GSE74704 ATP2B2 491 1 10 9
TCGA ATP2B2 491 4 67 25

Total number of gains: 27; Total number of losses: 221; Total Number of normals: 240.  

 

Somatic mutations of ATP2B2:

 

Generating mutation plots.

 

Highly correlated genes for ATP2B2:

 

Showing top 20/783 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ATP2B2SALL30.83811303
ATP2B2UFSP10.826548303
ATP2B2SPACA30.820593404
ATP2B2PHGR10.777566303
ATP2B2STX1B0.766347303
ATP2B2FBN30.755054303
ATP2B2SHISA80.750588403
ATP2B2PRAP10.738042303
ATP2B2CTSE0.735204303
ATP2B2ARL5C0.734471303
ATP2B2ZBBX0.729936303
ATP2B2GRID20.729474303
ATP2B2PSMB110.726053303
ATP2B2ATP8A20.725509404
ATP2B2DEFB1280.724934303
ATP2B2RIMS40.724271404
ATP2B2OTUD50.723631303
ATP2B2RASL10B0.723036404
ATP2B2MRGPRE0.71404303
ATP2B2MAMSTR0.705375403

For details and further investigation, click here