ADCY2

 

Full name: adenylate cyclase 2 Alias Symbol: HBAC2|KIAA1060|AC2
Type: protein-coding gene Cytoband: 5p15.31
Entrez ID: 108 HGNC ID: HGNC:233 Ensembl Gene: ENSG00000078295 OMIM ID: 103071
Drug and gene relationship at DGIdb

 

ADCY2 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05032Morphine addiction
hsa05166HTLV-I infection

 

Expression of ADCY2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADCY2 108 213217_at -0.9678 0.1601
GSE20347 ADCY2 108 213217_at 0.0425 0.7661
GSE23400 ADCY2 108 213217_at -0.1019 0.1622
GSE26886 ADCY2 108 213217_at 0.2753 0.3468
GSE29001 ADCY2 108 213217_at 0.0027 0.9920
GSE38129 ADCY2 108 213217_at -0.3286 0.1989
GSE45670 ADCY2 108 213217_at -0.4905 0.0712
GSE53622 ADCY2 108 82744 0.9490 0.0000
GSE53624 ADCY2 108 82744 0.9359 0.0000
GSE63941 ADCY2 108 213217_at -0.5314 0.0007
GSE77861 ADCY2 108 213217_at 0.0479 0.7532
SRP064894 ADCY2 108 RNAseq 0.4746 0.2626
SRP133303 ADCY2 108 RNAseq -0.0856 0.8236
SRP159526 ADCY2 108 RNAseq 0.8361 0.2276
SRP193095 ADCY2 108 RNAseq 0.2471 0.2895
SRP219564 ADCY2 108 RNAseq 0.9855 0.3821
TCGA ADCY2 108 RNAseq -0.8268 0.0619

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ADCY2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADCY2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADCY2 108 12 0 18
GSE20123 ADCY2 108 12 0 18
GSE43470 ADCY2 108 16 0 27
GSE46452 ADCY2 108 6 22 31
GSE47630 ADCY2 108 6 11 23
GSE54993 ADCY2 108 5 5 60
GSE54994 ADCY2 108 30 1 22
GSE60625 ADCY2 108 0 0 11
GSE74703 ADCY2 108 12 0 24
GSE74704 ADCY2 108 11 0 9
TCGA ADCY2 108 57 4 35

Total number of gains: 167; Total number of losses: 43; Total Number of normals: 278.  

 

Somatic mutations of ADCY2:

 

Generating mutation plots.

 

Highly correlated genes for ADCY2:

 

Showing top 20/268 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADCY2ALDH1B10.739806505
ADCY2KCNN30.689783404
ADCY2FLNA0.685642505
ADCY2ELAVL40.676115303
ADCY2GNAZ0.674676806
ADCY2EMCN0.671705403
ADCY2DGKG0.669058404
ADCY2EPHA70.668837303
ADCY2CNGA30.667983706
ADCY2SH3GL20.667913707
ADCY2NT5DC30.666573404
ADCY2SNAP910.666138605
ADCY2CELF60.665651303
ADCY2ITPKB0.664753404
ADCY2HRC0.663223303
ADCY2PEG30.662507504
ADCY2CCDC1360.662482403
ADCY2MXRA70.660967404
ADCY2MPDZ0.660933604
ADCY2TCEAL20.65601706

For details and further investigation, click here