| Full name: EPH receptor A7 | Alias Symbol: Hek11 | ||
| Type: protein-coding gene | Cytoband: 6q16.1 | ||
| Entrez ID: 2045 | HGNC ID: HGNC:3390 | Ensembl Gene: ENSG00000135333 | OMIM ID: 602190 |
| Drug and gene relationship at DGIdb | |||
EPHA7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EPHA7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHA7 | 2045 | 229288_at | -0.6847 | 0.8543 | |
| GSE20347 | EPHA7 | 2045 | 206852_at | 0.2026 | 0.2030 | |
| GSE23400 | EPHA7 | 2045 | 206852_at | -0.0948 | 0.2924 | |
| GSE26886 | EPHA7 | 2045 | 229288_at | 0.6283 | 0.0206 | |
| GSE29001 | EPHA7 | 2045 | 206852_at | -0.0442 | 0.7510 | |
| GSE38129 | EPHA7 | 2045 | 206852_at | -0.0532 | 0.7932 | |
| GSE45670 | EPHA7 | 2045 | 229288_at | -0.5284 | 0.5692 | |
| GSE53622 | EPHA7 | 2045 | 817 | -0.2114 | 0.6439 | |
| GSE53624 | EPHA7 | 2045 | 817 | 0.6856 | 0.0012 | |
| GSE63941 | EPHA7 | 2045 | 229288_at | 0.0204 | 0.9746 | |
| GSE77861 | EPHA7 | 2045 | 229288_at | 1.2937 | 0.1505 | |
| GSE97050 | EPHA7 | 2045 | A_23_P7835 | -1.8432 | 0.1363 | |
| SRP007169 | EPHA7 | 2045 | RNAseq | 5.5369 | 0.0000 | |
| SRP133303 | EPHA7 | 2045 | RNAseq | 1.3571 | 0.1882 | |
| SRP159526 | EPHA7 | 2045 | RNAseq | 3.4435 | 0.0000 | |
| TCGA | EPHA7 | 2045 | RNAseq | -0.3753 | 0.4167 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by EPHA7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHA7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHA7 | 2045 | 1 | 6 | 23 | |
| GSE20123 | EPHA7 | 2045 | 1 | 5 | 24 | |
| GSE43470 | EPHA7 | 2045 | 2 | 3 | 38 | |
| GSE46452 | EPHA7 | 2045 | 2 | 11 | 46 | |
| GSE47630 | EPHA7 | 2045 | 8 | 6 | 26 | |
| GSE54993 | EPHA7 | 2045 | 3 | 2 | 65 | |
| GSE54994 | EPHA7 | 2045 | 8 | 8 | 37 | |
| GSE60625 | EPHA7 | 2045 | 0 | 1 | 10 | |
| GSE74703 | EPHA7 | 2045 | 2 | 3 | 31 | |
| GSE74704 | EPHA7 | 2045 | 0 | 2 | 18 | |
| TCGA | EPHA7 | 2045 | 5 | 25 | 66 |
Total number of gains: 32; Total number of losses: 72; Total Number of normals: 384.
Somatic mutations of EPHA7:
Generating mutation plots.
Highly correlated genes for EPHA7:
Showing top 20/579 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHA7 | ILDR2 | 0.766836 | 3 | 0 | 3 |
| EPHA7 | FABP7 | 0.763526 | 3 | 0 | 3 |
| EPHA7 | ARHGEF25 | 0.758436 | 3 | 0 | 3 |
| EPHA7 | DNAJB5 | 0.757909 | 4 | 0 | 4 |
| EPHA7 | CSN3 | 0.755539 | 3 | 0 | 3 |
| EPHA7 | HAND2 | 0.755396 | 5 | 0 | 5 |
| EPHA7 | ANO5 | 0.755146 | 3 | 0 | 3 |
| EPHA7 | LRCH2 | 0.753171 | 3 | 0 | 3 |
| EPHA7 | ADARB1 | 0.75013 | 5 | 0 | 5 |
| EPHA7 | PLCL1 | 0.748589 | 6 | 0 | 6 |
| EPHA7 | SLC35F1 | 0.736197 | 3 | 0 | 3 |
| EPHA7 | PPP1R12A | 0.733641 | 5 | 0 | 5 |
| EPHA7 | DCLK2 | 0.732947 | 4 | 0 | 4 |
| EPHA7 | FAM124A | 0.723559 | 3 | 0 | 3 |
| EPHA7 | SLIT2 | 0.722367 | 6 | 0 | 6 |
| EPHA7 | INMT | 0.721298 | 4 | 0 | 4 |
| EPHA7 | KANK2 | 0.715044 | 5 | 0 | 5 |
| EPHA7 | MAP1LC3A | 0.710497 | 3 | 0 | 3 |
| EPHA7 | PARD3B | 0.709524 | 3 | 0 | 3 |
| EPHA7 | PTCHD1 | 0.70846 | 3 | 0 | 3 |
For details and further investigation, click here
