| Full name: SH3 domain containing GRB2 like 2, endophilin A1 | Alias Symbol: SH3P4|SH3D2A|CNSA2|EEN-B1 | ||
| Type: protein-coding gene | Cytoband: 9p22.2 | ||
| Entrez ID: 6456 | HGNC ID: HGNC:10831 | Ensembl Gene: ENSG00000107295 | OMIM ID: 604465 |
| Drug and gene relationship at DGIdb | |||
Expression of SH3GL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3GL2 | 6456 | 205751_at | -0.7413 | 0.6366 | |
| GSE20347 | SH3GL2 | 6456 | 205751_at | -0.0629 | 0.5191 | |
| GSE23400 | SH3GL2 | 6456 | 205751_at | -0.1178 | 0.0237 | |
| GSE26886 | SH3GL2 | 6456 | 205751_at | 0.7299 | 0.0985 | |
| GSE29001 | SH3GL2 | 6456 | 205751_at | -0.0077 | 0.9841 | |
| GSE38129 | SH3GL2 | 6456 | 205751_at | -0.5117 | 0.1698 | |
| GSE45670 | SH3GL2 | 6456 | 205751_at | -0.4703 | 0.3084 | |
| GSE53622 | SH3GL2 | 6456 | 51410 | -0.8517 | 0.0156 | |
| GSE53624 | SH3GL2 | 6456 | 51410 | -0.5882 | 0.0152 | |
| GSE63941 | SH3GL2 | 6456 | 205751_at | 0.5514 | 0.4663 | |
| GSE77861 | SH3GL2 | 6456 | 205751_at | -0.0366 | 0.6991 | |
| GSE97050 | SH3GL2 | 6456 | A_23_P169351 | -0.5232 | 0.2131 | |
| TCGA | SH3GL2 | 6456 | RNAseq | -3.0568 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SH3GL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH3GL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3GL2 | 6456 | 2 | 16 | 12 | |
| GSE20123 | SH3GL2 | 6456 | 2 | 16 | 12 | |
| GSE43470 | SH3GL2 | 6456 | 4 | 11 | 28 | |
| GSE46452 | SH3GL2 | 6456 | 2 | 23 | 34 | |
| GSE47630 | SH3GL2 | 6456 | 3 | 27 | 10 | |
| GSE54993 | SH3GL2 | 6456 | 6 | 2 | 62 | |
| GSE54994 | SH3GL2 | 6456 | 10 | 16 | 27 | |
| GSE60625 | SH3GL2 | 6456 | 0 | 0 | 11 | |
| GSE74703 | SH3GL2 | 6456 | 4 | 8 | 24 | |
| GSE74704 | SH3GL2 | 6456 | 0 | 13 | 7 | |
| TCGA | SH3GL2 | 6456 | 14 | 51 | 31 |
Total number of gains: 47; Total number of losses: 183; Total Number of normals: 258.
Somatic mutations of SH3GL2:
Generating mutation plots.
Highly correlated genes for SH3GL2:
Showing top 20/676 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3GL2 | SLC35F1 | 0.785215 | 5 | 0 | 5 |
| SH3GL2 | PGR | 0.75959 | 5 | 0 | 5 |
| SH3GL2 | WSCD2 | 0.75898 | 4 | 0 | 3 |
| SH3GL2 | ITIH6 | 0.74387 | 3 | 0 | 3 |
| SH3GL2 | BRINP3 | 0.736858 | 7 | 0 | 7 |
| SH3GL2 | VIP | 0.734991 | 7 | 0 | 7 |
| SH3GL2 | ZNF609 | 0.734081 | 3 | 0 | 3 |
| SH3GL2 | ANO6 | 0.732194 | 3 | 0 | 3 |
| SH3GL2 | KIF5C | 0.731355 | 9 | 0 | 9 |
| SH3GL2 | CAMK2G | 0.729114 | 5 | 0 | 5 |
| SH3GL2 | LRCH2 | 0.728806 | 6 | 0 | 5 |
| SH3GL2 | PCDH9 | 0.727247 | 7 | 0 | 6 |
| SH3GL2 | ANO5 | 0.725736 | 5 | 0 | 5 |
| SH3GL2 | DPH3 | 0.725147 | 3 | 0 | 3 |
| SH3GL2 | SYT4 | 0.723596 | 4 | 0 | 4 |
| SH3GL2 | SYNC | 0.721846 | 5 | 0 | 5 |
| SH3GL2 | MYEF2 | 0.721315 | 4 | 0 | 3 |
| SH3GL2 | DPP10 | 0.720146 | 4 | 0 | 4 |
| SH3GL2 | SMTN | 0.718842 | 5 | 0 | 4 |
| SH3GL2 | PDGFRL | 0.718825 | 4 | 0 | 4 |
For details and further investigation, click here
