| Full name: potassium calcium-activated channel subfamily N member 3 | Alias Symbol: KCa2.3|hSK3|SKCA3 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 3782 | HGNC ID: HGNC:6292 | Ensembl Gene: ENSG00000143603 | OMIM ID: 602983 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNN3 | 3782 | 205902_at | -0.3751 | 0.6349 | |
| GSE20347 | KCNN3 | 3782 | 205902_at | 0.3487 | 0.0633 | |
| GSE23400 | KCNN3 | 3782 | 205902_at | -0.3318 | 0.0000 | |
| GSE26886 | KCNN3 | 3782 | 205902_at | 0.2239 | 0.2216 | |
| GSE29001 | KCNN3 | 3782 | 205902_at | 0.0105 | 0.9806 | |
| GSE38129 | KCNN3 | 3782 | 205902_at | -0.4675 | 0.1357 | |
| GSE45670 | KCNN3 | 3782 | 205903_s_at | 0.0015 | 0.9948 | |
| GSE53622 | KCNN3 | 3782 | 46182 | -0.2662 | 0.1707 | |
| GSE53624 | KCNN3 | 3782 | 46182 | 0.3340 | 0.0144 | |
| GSE63941 | KCNN3 | 3782 | 231103_at | -0.1150 | 0.4528 | |
| GSE77861 | KCNN3 | 3782 | 231103_at | -0.0743 | 0.5077 | |
| GSE97050 | KCNN3 | 3782 | A_23_P126167 | -0.5900 | 0.3704 | |
| SRP007169 | KCNN3 | 3782 | RNAseq | 1.0272 | 0.1086 | |
| SRP064894 | KCNN3 | 3782 | RNAseq | -0.4329 | 0.1147 | |
| SRP133303 | KCNN3 | 3782 | RNAseq | -0.9370 | 0.0010 | |
| SRP159526 | KCNN3 | 3782 | RNAseq | -0.1820 | 0.7808 | |
| SRP193095 | KCNN3 | 3782 | RNAseq | 0.3877 | 0.1494 | |
| TCGA | KCNN3 | 3782 | RNAseq | -0.3951 | 0.0753 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KCNN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNN3 | 3782 | 14 | 0 | 16 | |
| GSE20123 | KCNN3 | 3782 | 14 | 0 | 16 | |
| GSE43470 | KCNN3 | 3782 | 6 | 2 | 35 | |
| GSE46452 | KCNN3 | 3782 | 2 | 1 | 56 | |
| GSE47630 | KCNN3 | 3782 | 14 | 0 | 26 | |
| GSE54993 | KCNN3 | 3782 | 0 | 4 | 66 | |
| GSE54994 | KCNN3 | 3782 | 16 | 0 | 37 | |
| GSE60625 | KCNN3 | 3782 | 0 | 0 | 11 | |
| GSE74703 | KCNN3 | 3782 | 6 | 1 | 29 | |
| GSE74704 | KCNN3 | 3782 | 7 | 0 | 13 | |
| TCGA | KCNN3 | 3782 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 10; Total Number of normals: 361.
Somatic mutations of KCNN3:
Generating mutation plots.
Highly correlated genes for KCNN3:
Showing top 20/673 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNN3 | RBM24 | 0.794295 | 3 | 0 | 3 |
| KCNN3 | JAZF1 | 0.77396 | 3 | 0 | 3 |
| KCNN3 | PGR | 0.770337 | 3 | 0 | 3 |
| KCNN3 | PCDH9 | 0.751917 | 5 | 0 | 5 |
| KCNN3 | MYOC | 0.720386 | 5 | 0 | 4 |
| KCNN3 | PDZD4 | 0.718349 | 4 | 0 | 3 |
| KCNN3 | SH3BGR | 0.716697 | 5 | 0 | 4 |
| KCNN3 | CBX7 | 0.713471 | 6 | 0 | 6 |
| KCNN3 | ZNF449 | 0.712231 | 3 | 0 | 3 |
| KCNN3 | IQUB | 0.711135 | 3 | 0 | 3 |
| KCNN3 | PRKAR2B | 0.709691 | 5 | 0 | 5 |
| KCNN3 | CCDC69 | 0.706549 | 5 | 0 | 4 |
| KCNN3 | FGL2 | 0.700352 | 5 | 0 | 5 |
| KCNN3 | THRA | 0.700142 | 4 | 0 | 3 |
| KCNN3 | PEBP4 | 0.699815 | 4 | 0 | 3 |
| KCNN3 | GPRASP1 | 0.699594 | 5 | 0 | 4 |
| KCNN3 | C1orf21 | 0.697131 | 3 | 0 | 3 |
| KCNN3 | TRAK2 | 0.696744 | 5 | 0 | 4 |
| KCNN3 | PITPNM2 | 0.695748 | 3 | 0 | 3 |
| KCNN3 | ATP1A2 | 0.695329 | 4 | 0 | 4 |
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