ADCY6

 

Full name: adenylate cyclase 6 Alias Symbol: AC6
Type: protein-coding gene Cytoband: 12q13.12
Entrez ID: 112 HGNC ID: HGNC:237 Ensembl Gene: ENSG00000174233 OMIM ID: 600294
Drug and gene relationship at DGIdb

 

ADCY6 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04742Taste transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05032Morphine addiction
hsa05166HTLV-I infection

 

Expression of ADCY6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADCY6 112 209195_s_at -0.2841 0.4570
GSE20347 ADCY6 112 209195_s_at -0.3404 0.0006
GSE23400 ADCY6 112 209195_s_at -0.2735 0.0000
GSE26886 ADCY6 112 209195_s_at -0.7068 0.0000
GSE29001 ADCY6 112 209195_s_at -0.3406 0.0233
GSE38129 ADCY6 112 209195_s_at -0.4043 0.0001
GSE45670 ADCY6 112 209195_s_at -0.3075 0.0587
GSE53622 ADCY6 112 114047 -1.7176 0.0000
GSE53624 ADCY6 112 114047 -1.2361 0.0000
GSE63941 ADCY6 112 209195_s_at -0.4402 0.3116
GSE77861 ADCY6 112 209195_s_at -0.3066 0.0204
GSE97050 ADCY6 112 A_23_P501547 -0.4221 0.2069
SRP007169 ADCY6 112 RNAseq -1.5273 0.0036
SRP008496 ADCY6 112 RNAseq -1.1305 0.0026
SRP064894 ADCY6 112 RNAseq -0.4896 0.0113
SRP133303 ADCY6 112 RNAseq -0.9505 0.0000
SRP159526 ADCY6 112 RNAseq -0.7247 0.0175
SRP193095 ADCY6 112 RNAseq -0.4287 0.0697
SRP219564 ADCY6 112 RNAseq -0.8027 0.0395
TCGA ADCY6 112 RNAseq -0.6641 0.0000

Upregulated datasets: 0; Downregulated datasets: 4.  

 

Survival by ADCY6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADCY6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADCY6 112 5 1 24
GSE20123 ADCY6 112 5 1 24
GSE43470 ADCY6 112 4 1 38
GSE46452 ADCY6 112 8 1 50
GSE47630 ADCY6 112 11 2 27
GSE54993 ADCY6 112 0 5 65
GSE54994 ADCY6 112 6 1 46
GSE60625 ADCY6 112 0 0 11
GSE74703 ADCY6 112 4 1 31
GSE74704 ADCY6 112 3 1 16
TCGA ADCY6 112 16 12 68

Total number of gains: 62; Total number of losses: 26; Total Number of normals: 400.  

 

Somatic mutations of ADCY6:

 

Generating mutation plots.

 

Highly correlated genes for ADCY6:

 

Showing top 20/1378 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADCY6RBPMS20.797571404
ADCY6MYOCD0.759878505
ADCY6CLEC3B0.753117303
ADCY6PRKAG20.748746303
ADCY6SMO0.738971303
ADCY6LONRF20.734884505
ADCY6C2orf880.728031303
ADCY6EIF4E30.722836707
ADCY6NEXN0.719022404
ADCY6ZNF7840.710374403
ADCY6PPM1K0.709236808
ADCY6SORCS10.704619404
ADCY6PI4KA0.702528303
ADCY6MEOX20.700775403
ADCY6VMAC0.698629303
ADCY6PPM1L0.692479605
ADCY6ZMAT10.689623706
ADCY6ZNF5830.689341404
ADCY6ZNF6150.689093505
ADCY6MIR100HG0.685501303

For details and further investigation, click here