| Full name: phosphatidylinositol 4-kinase alpha | Alias Symbol: PI4K-ALPHA|pi4K230 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 5297 | HGNC ID: HGNC:8983 | Ensembl Gene: ENSG00000241973 | OMIM ID: 600286 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PI4KA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PI4KA | 5297 | 207081_s_at | 0.0790 | 0.9113 | |
| GSE20347 | PI4KA | 5297 | 207081_s_at | 0.1045 | 0.4056 | |
| GSE23400 | PI4KA | 5297 | 207081_s_at | 0.1374 | 0.1347 | |
| GSE26886 | PI4KA | 5297 | 207081_s_at | 0.2681 | 0.2378 | |
| GSE29001 | PI4KA | 5297 | 207081_s_at | 0.1524 | 0.6702 | |
| GSE38129 | PI4KA | 5297 | 207081_s_at | 0.0051 | 0.9784 | |
| GSE45670 | PI4KA | 5297 | 207081_s_at | 0.0945 | 0.7392 | |
| GSE53622 | PI4KA | 5297 | 61826 | 0.0986 | 0.1274 | |
| GSE53624 | PI4KA | 5297 | 61826 | 0.0868 | 0.2232 | |
| GSE63941 | PI4KA | 5297 | 207081_s_at | -0.4134 | 0.5539 | |
| GSE77861 | PI4KA | 5297 | 207081_s_at | 0.7417 | 0.0533 | |
| GSE97050 | PI4KA | A_21_P0012340 | -0.0415 | 0.8956 | ||
| SRP007169 | PI4KA | 5297 | RNAseq | 0.4392 | 0.3043 | |
| SRP008496 | PI4KA | 5297 | RNAseq | 0.1715 | 0.4595 | |
| SRP064894 | PI4KA | 5297 | RNAseq | 0.3400 | 0.0186 | |
| SRP133303 | PI4KA | 5297 | RNAseq | 0.0236 | 0.8305 | |
| SRP159526 | PI4KA | 5297 | RNAseq | 0.1731 | 0.3632 | |
| SRP193095 | PI4KA | 5297 | RNAseq | 0.2666 | 0.0156 | |
| SRP219564 | PI4KA | 5297 | RNAseq | 0.2720 | 0.2670 | |
| TCGA | PI4KA | 5297 | RNAseq | -0.1602 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PI4KA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PI4KA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PI4KA | 5297 | 6 | 7 | 17 | |
| GSE20123 | PI4KA | 5297 | 6 | 7 | 17 | |
| GSE43470 | PI4KA | 5297 | 4 | 7 | 32 | |
| GSE46452 | PI4KA | 5297 | 33 | 1 | 25 | |
| GSE47630 | PI4KA | 5297 | 8 | 5 | 27 | |
| GSE54993 | PI4KA | 5297 | 3 | 6 | 61 | |
| GSE54994 | PI4KA | 5297 | 11 | 7 | 35 | |
| GSE60625 | PI4KA | 5297 | 5 | 0 | 6 | |
| GSE74703 | PI4KA | 5297 | 4 | 5 | 27 | |
| GSE74704 | PI4KA | 5297 | 3 | 4 | 13 | |
| TCGA | PI4KA | 5297 | 27 | 17 | 52 |
Total number of gains: 110; Total number of losses: 66; Total Number of normals: 312.
Somatic mutations of PI4KA:
Generating mutation plots.
Highly correlated genes for PI4KA:
Showing top 20/544 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PI4KA | KCTD13 | 0.795577 | 3 | 0 | 3 |
| PI4KA | MEPCE | 0.757228 | 3 | 0 | 3 |
| PI4KA | C20orf194 | 0.741124 | 3 | 0 | 3 |
| PI4KA | DEDD | 0.737814 | 3 | 0 | 3 |
| PI4KA | AHCTF1 | 0.721885 | 3 | 0 | 3 |
| PI4KA | R3HDM2 | 0.721257 | 3 | 0 | 3 |
| PI4KA | RNASE1 | 0.711604 | 3 | 0 | 3 |
| PI4KA | ZNF266 | 0.7036 | 3 | 0 | 3 |
| PI4KA | ADCY6 | 0.702528 | 3 | 0 | 3 |
| PI4KA | RILPL1 | 0.698605 | 4 | 0 | 3 |
| PI4KA | MFAP5 | 0.698564 | 3 | 0 | 3 |
| PI4KA | TNFRSF1A | 0.696291 | 3 | 0 | 3 |
| PI4KA | POMGNT1 | 0.694632 | 3 | 0 | 3 |
| PI4KA | SHANK3 | 0.691865 | 3 | 0 | 3 |
| PI4KA | HABP4 | 0.691272 | 3 | 0 | 3 |
| PI4KA | ADAM23 | 0.690752 | 4 | 0 | 3 |
| PI4KA | CBX5 | 0.685735 | 3 | 0 | 3 |
| PI4KA | GORAB | 0.683391 | 3 | 0 | 3 |
| PI4KA | STAT5A | 0.682155 | 3 | 0 | 3 |
| PI4KA | IWS1 | 0.681468 | 4 | 0 | 4 |
For details and further investigation, click here
