PRKAG2

 

Full name: protein kinase AMP-activated non-catalytic subunit gamma 2 Alias Symbol: AAKG|AAKG2|H91620p|WPWS|CMH6
Type: protein-coding gene Cytoband: 7q36.1
Entrez ID: 51422 HGNC ID: HGNC:9386 Ensembl Gene: ENSG00000106617 OMIM ID: 602743
Drug and gene relationship at DGIdb
Screen Evidence:

 

PRKAG2 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04710Circadian rhythm
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)

 

Expression of PRKAG2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKAG2 51422 233748_x_at -0.6679 0.3115
GSE20347 PRKAG2 51422 218292_s_at 0.0654 0.5484
GSE23400 PRKAG2 51422 218292_s_at -0.0436 0.3850
GSE26886 PRKAG2 51422 231224_x_at 0.0999 0.2818
GSE29001 PRKAG2 51422 218292_s_at -0.3549 0.0138
GSE38129 PRKAG2 51422 218292_s_at -0.1670 0.2794
GSE45670 PRKAG2 51422 222582_at -0.7031 0.0052
GSE53622 PRKAG2 51422 74146 -0.4846 0.0000
GSE53624 PRKAG2 51422 63835 -0.2101 0.0031
GSE63941 PRKAG2 51422 233748_x_at -1.0238 0.0229
GSE77861 PRKAG2 51422 222582_at 0.1725 0.2931
GSE97050 PRKAG2 51422 A_23_P314760 -0.2010 0.6431
SRP007169 PRKAG2 51422 RNAseq 1.3768 0.0074
SRP008496 PRKAG2 51422 RNAseq 0.7644 0.0233
SRP064894 PRKAG2 51422 RNAseq -0.4111 0.0450
SRP133303 PRKAG2 51422 RNAseq -0.1029 0.5947
SRP159526 PRKAG2 51422 RNAseq -0.2001 0.5698
SRP193095 PRKAG2 51422 RNAseq 0.0472 0.7942
SRP219564 PRKAG2 51422 RNAseq 0.0663 0.9133
TCGA PRKAG2 51422 RNAseq -0.4316 0.0000

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by PRKAG2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKAG2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKAG2 51422 2 4 24
GSE20123 PRKAG2 51422 2 4 24
GSE43470 PRKAG2 51422 2 5 36
GSE46452 PRKAG2 51422 7 2 50
GSE47630 PRKAG2 51422 6 9 25
GSE54993 PRKAG2 51422 3 3 64
GSE54994 PRKAG2 51422 5 8 40
GSE60625 PRKAG2 51422 0 0 11
GSE74703 PRKAG2 51422 2 4 30
GSE74704 PRKAG2 51422 1 4 15
TCGA PRKAG2 51422 27 26 43

Total number of gains: 57; Total number of losses: 69; Total Number of normals: 362.  

 

Somatic mutations of PRKAG2:

 

Generating mutation plots.

 

Highly correlated genes for PRKAG2:

 

Showing top 20/632 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKAG2EID30.805635303
PRKAG2ADCY60.748746303
PRKAG2PNKD0.726293303
PRKAG2CCDC1360.723518303
PRKAG2MYCT10.722992303
PRKAG2SYNC0.722402505
PRKAG2ING40.718417303
PRKAG2UBXN100.717913303
PRKAG2ZBTB260.715673303
PRKAG2IGSF100.713635303
PRKAG2RHEB0.707772606
PRKAG2RNF1300.701427303
PRKAG2CCDC1210.700364303
PRKAG2FIBIN0.700001404
PRKAG2CHIC10.699983303
PRKAG2N6AMT10.696572404
PRKAG2DNALI10.694735605
PRKAG2ECSCR0.694544303
PRKAG2PODN0.693849403
PRKAG2NEK70.69335303

For details and further investigation, click here