| Full name: gap junction protein alpha 3 | Alias Symbol: CX46 | ||
| Type: protein-coding gene | Cytoband: 13q12.11 | ||
| Entrez ID: 2700 | HGNC ID: HGNC:4277 | Ensembl Gene: ENSG00000121743 | OMIM ID: 121015 |
| Drug and gene relationship at DGIdb | |||
Expression of GJA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJA3 | 2700 | 239572_at | 0.5216 | 0.8039 | |
| GSE20347 | GJA3 | 2700 | 208590_x_at | -0.1190 | 0.0834 | |
| GSE23400 | GJA3 | 2700 | 208590_x_at | -0.2010 | 0.0000 | |
| GSE26886 | GJA3 | 2700 | 208590_x_at | 0.1251 | 0.3294 | |
| GSE29001 | GJA3 | 2700 | 208590_x_at | -0.2140 | 0.0365 | |
| GSE38129 | GJA3 | 2700 | 208590_x_at | -0.1518 | 0.0224 | |
| GSE45670 | GJA3 | 2700 | 239572_at | 1.5493 | 0.0061 | |
| GSE53622 | GJA3 | 2700 | 75242 | 1.1023 | 0.0001 | |
| GSE53624 | GJA3 | 2700 | 75242 | 0.9573 | 0.0000 | |
| GSE63941 | GJA3 | 2700 | 239572_at | -2.7351 | 0.0129 | |
| GSE77861 | GJA3 | 2700 | 208590_x_at | -0.2141 | 0.1353 | |
| GSE97050 | GJA3 | 2700 | A_32_P205241 | 0.3722 | 0.2819 | |
| SRP133303 | GJA3 | 2700 | RNAseq | 2.0661 | 0.0002 | |
| SRP159526 | GJA3 | 2700 | RNAseq | 0.8458 | 0.1602 | |
| TCGA | GJA3 | 2700 | RNAseq | 2.0900 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by GJA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GJA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJA3 | 2700 | 1 | 16 | 13 | |
| GSE20123 | GJA3 | 2700 | 1 | 15 | 14 | |
| GSE43470 | GJA3 | 2700 | 1 | 13 | 29 | |
| GSE46452 | GJA3 | 2700 | 0 | 33 | 26 | |
| GSE47630 | GJA3 | 2700 | 3 | 26 | 11 | |
| GSE54993 | GJA3 | 2700 | 11 | 2 | 57 | |
| GSE54994 | GJA3 | 2700 | 1 | 13 | 39 | |
| GSE60625 | GJA3 | 2700 | 0 | 3 | 8 | |
| GSE74703 | GJA3 | 2700 | 1 | 10 | 25 | |
| GSE74704 | GJA3 | 2700 | 0 | 13 | 7 | |
| TCGA | GJA3 | 2700 | 6 | 43 | 47 |
Total number of gains: 25; Total number of losses: 187; Total Number of normals: 276.
Somatic mutations of GJA3:
Generating mutation plots.
Highly correlated genes for GJA3:
Showing top 20/353 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJA3 | GLTPD2 | 0.803152 | 3 | 0 | 3 |
| GJA3 | ABCG4 | 0.758699 | 4 | 0 | 4 |
| GJA3 | RNF17 | 0.733617 | 3 | 0 | 3 |
| GJA3 | POU6F2 | 0.733585 | 3 | 0 | 3 |
| GJA3 | ATP12A | 0.729774 | 3 | 0 | 3 |
| GJA3 | AQP2 | 0.718151 | 4 | 0 | 4 |
| GJA3 | MMP25 | 0.713098 | 3 | 0 | 3 |
| GJA3 | WFDC5 | 0.706522 | 4 | 0 | 4 |
| GJA3 | AMER3 | 0.704666 | 3 | 0 | 3 |
| GJA3 | CELF4 | 0.691991 | 3 | 0 | 3 |
| GJA3 | DLGAP3 | 0.689045 | 3 | 0 | 3 |
| GJA3 | LIM2 | 0.687927 | 4 | 0 | 4 |
| GJA3 | VGF | 0.684521 | 4 | 0 | 3 |
| GJA3 | SLC22A13 | 0.681961 | 5 | 0 | 5 |
| GJA3 | PAX7 | 0.678401 | 3 | 0 | 3 |
| GJA3 | IMPG2 | 0.672812 | 3 | 0 | 3 |
| GJA3 | NKAIN1 | 0.668017 | 3 | 0 | 3 |
| GJA3 | AICDA | 0.667789 | 3 | 0 | 3 |
| GJA3 | KLK14 | 0.667428 | 6 | 0 | 5 |
| GJA3 | CDSN | 0.665328 | 3 | 0 | 3 |
For details and further investigation, click here
