| Full name: GRB2 related adaptor protein 2 | Alias Symbol: Grf40|GrbX|GRBLG|GADS|Mona | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 9402 | HGNC ID: HGNC:4563 | Ensembl Gene: ENSG00000100351 | OMIM ID: 604518 |
| Drug and gene relationship at DGIdb | |||
GRAP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04660 | T cell receptor signaling pathway |
Expression of GRAP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRAP2 | 9402 | 208406_s_at | -0.0664 | 0.7956 | |
| GSE20347 | GRAP2 | 9402 | 208406_s_at | -0.0582 | 0.4749 | |
| GSE23400 | GRAP2 | 9402 | 208406_s_at | -0.2085 | 0.0000 | |
| GSE26886 | GRAP2 | 9402 | 208406_s_at | 0.0380 | 0.7489 | |
| GSE29001 | GRAP2 | 9402 | 208406_s_at | -0.0739 | 0.5555 | |
| GSE38129 | GRAP2 | 9402 | 208406_s_at | -0.1243 | 0.1028 | |
| GSE45670 | GRAP2 | 9402 | 208406_s_at | -0.0140 | 0.8931 | |
| GSE53622 | GRAP2 | 9402 | 20609 | -0.6857 | 0.0000 | |
| GSE53624 | GRAP2 | 9402 | 20609 | -0.9536 | 0.0000 | |
| GSE63941 | GRAP2 | 9402 | 208406_s_at | 0.1057 | 0.5042 | |
| GSE77861 | GRAP2 | 9402 | 208406_s_at | -0.2643 | 0.0770 | |
| GSE97050 | GRAP2 | 9402 | A_24_P10884 | 0.5647 | 0.2681 | |
| SRP064894 | GRAP2 | 9402 | RNAseq | -0.7296 | 0.0285 | |
| SRP133303 | GRAP2 | 9402 | RNAseq | -0.9739 | 0.0136 | |
| SRP159526 | GRAP2 | 9402 | RNAseq | -0.9084 | 0.2453 | |
| SRP193095 | GRAP2 | 9402 | RNAseq | -0.3844 | 0.0787 | |
| SRP219564 | GRAP2 | 9402 | RNAseq | 0.0813 | 0.8817 | |
| TCGA | GRAP2 | 9402 | RNAseq | -0.1729 | 0.5553 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GRAP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRAP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRAP2 | 9402 | 6 | 5 | 19 | |
| GSE20123 | GRAP2 | 9402 | 6 | 4 | 20 | |
| GSE43470 | GRAP2 | 9402 | 5 | 6 | 32 | |
| GSE46452 | GRAP2 | 9402 | 31 | 2 | 26 | |
| GSE47630 | GRAP2 | 9402 | 9 | 4 | 27 | |
| GSE54993 | GRAP2 | 9402 | 3 | 6 | 61 | |
| GSE54994 | GRAP2 | 9402 | 9 | 8 | 36 | |
| GSE60625 | GRAP2 | 9402 | 5 | 0 | 6 | |
| GSE74703 | GRAP2 | 9402 | 5 | 4 | 27 | |
| GSE74704 | GRAP2 | 9402 | 3 | 2 | 15 | |
| TCGA | GRAP2 | 9402 | 27 | 15 | 54 |
Total number of gains: 109; Total number of losses: 56; Total Number of normals: 323.
Somatic mutations of GRAP2:
Generating mutation plots.
Highly correlated genes for GRAP2:
Showing top 20/617 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRAP2 | ARHGAP15 | 0.813578 | 3 | 0 | 3 |
| GRAP2 | GPR174 | 0.807549 | 3 | 0 | 3 |
| GRAP2 | CLDND2 | 0.794085 | 3 | 0 | 3 |
| GRAP2 | C16orf54 | 0.76934 | 3 | 0 | 3 |
| GRAP2 | FCRL3 | 0.750757 | 3 | 0 | 3 |
| GRAP2 | BTLA | 0.744272 | 3 | 0 | 3 |
| GRAP2 | MRPS18C | 0.720093 | 3 | 0 | 3 |
| GRAP2 | TIFAB | 0.719246 | 3 | 0 | 3 |
| GRAP2 | BNIP3 | 0.714135 | 3 | 0 | 3 |
| GRAP2 | INPP5D | 0.708081 | 5 | 0 | 4 |
| GRAP2 | SLC30A9 | 0.693114 | 3 | 0 | 3 |
| GRAP2 | MYCN | 0.690407 | 4 | 0 | 3 |
| GRAP2 | FLI1 | 0.68999 | 4 | 0 | 4 |
| GRAP2 | KCNA3 | 0.689944 | 6 | 0 | 6 |
| GRAP2 | UBA7 | 0.688228 | 3 | 0 | 3 |
| GRAP2 | ANKRD18A | 0.686291 | 3 | 0 | 3 |
| GRAP2 | TNFAIP8L2 | 0.684025 | 4 | 0 | 4 |
| GRAP2 | ACAP1 | 0.68236 | 5 | 0 | 4 |
| GRAP2 | ASMT | 0.681316 | 3 | 0 | 3 |
| GRAP2 | GIMAP7 | 0.676504 | 4 | 0 | 3 |
For details and further investigation, click here
