| Full name: DiGeorge syndrome critical region gene 2 | Alias Symbol: KIAA0163|LAN|IDD|DGS-C|SEZ-12 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 9993 | HGNC ID: HGNC:2845 | Ensembl Gene: ENSG00000070413 | OMIM ID: 600594 |
| Drug and gene relationship at DGIdb | |||
Expression of DGCR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DGCR2 | 9993 | 214198_s_at | 0.4456 | 0.1651 | |
| GSE20347 | DGCR2 | 9993 | 214198_s_at | -0.0959 | 0.4372 | |
| GSE23400 | DGCR2 | 9993 | 214198_s_at | 0.1036 | 0.1814 | |
| GSE26886 | DGCR2 | 9993 | 214198_s_at | 0.5337 | 0.0066 | |
| GSE29001 | DGCR2 | 9993 | 214198_s_at | -0.0035 | 0.9913 | |
| GSE38129 | DGCR2 | 9993 | 214198_s_at | 0.0672 | 0.6244 | |
| GSE45670 | DGCR2 | 9993 | 214198_s_at | 0.2151 | 0.0951 | |
| GSE53622 | DGCR2 | 9993 | 50306 | -0.4196 | 0.0000 | |
| GSE53624 | DGCR2 | 9993 | 50306 | -0.1947 | 0.0006 | |
| GSE63941 | DGCR2 | 9993 | 214198_s_at | -0.2294 | 0.7374 | |
| GSE77861 | DGCR2 | 9993 | 214198_s_at | 0.1651 | 0.2531 | |
| GSE97050 | DGCR2 | 9993 | A_24_P125881 | -0.5429 | 0.1344 | |
| SRP007169 | DGCR2 | 9993 | RNAseq | -0.5097 | 0.1282 | |
| SRP008496 | DGCR2 | 9993 | RNAseq | -0.5237 | 0.0083 | |
| SRP064894 | DGCR2 | 9993 | RNAseq | 0.3586 | 0.0597 | |
| SRP133303 | DGCR2 | 9993 | RNAseq | -0.1224 | 0.3914 | |
| SRP159526 | DGCR2 | 9993 | RNAseq | -0.0125 | 0.9541 | |
| SRP193095 | DGCR2 | 9993 | RNAseq | -0.0679 | 0.5303 | |
| SRP219564 | DGCR2 | 9993 | RNAseq | 0.0899 | 0.6687 | |
| TCGA | DGCR2 | 9993 | RNAseq | -0.0052 | 0.9031 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DGCR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DGCR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DGCR2 | 9993 | 4 | 8 | 18 | |
| GSE20123 | DGCR2 | 9993 | 4 | 8 | 18 | |
| GSE43470 | DGCR2 | 9993 | 5 | 7 | 31 | |
| GSE46452 | DGCR2 | 9993 | 33 | 1 | 25 | |
| GSE47630 | DGCR2 | 9993 | 8 | 5 | 27 | |
| GSE54993 | DGCR2 | 9993 | 3 | 6 | 61 | |
| GSE54994 | DGCR2 | 9993 | 12 | 7 | 34 | |
| GSE60625 | DGCR2 | 9993 | 5 | 0 | 6 | |
| GSE74703 | DGCR2 | 9993 | 5 | 5 | 26 | |
| GSE74704 | DGCR2 | 9993 | 2 | 5 | 13 | |
| TCGA | DGCR2 | 9993 | 27 | 17 | 52 |
Total number of gains: 108; Total number of losses: 69; Total Number of normals: 311.
Somatic mutations of DGCR2:
Generating mutation plots.
Highly correlated genes for DGCR2:
Showing top 20/390 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DGCR2 | NCAPG | 0.836169 | 3 | 0 | 3 |
| DGCR2 | FASTKD1 | 0.814776 | 3 | 0 | 3 |
| DGCR2 | GMEB2 | 0.813909 | 4 | 0 | 4 |
| DGCR2 | RICTOR | 0.802734 | 3 | 0 | 3 |
| DGCR2 | PSMB1 | 0.781962 | 4 | 0 | 4 |
| DGCR2 | HNRNPUL1 | 0.780914 | 3 | 0 | 3 |
| DGCR2 | ZBTB33 | 0.780571 | 3 | 0 | 3 |
| DGCR2 | CSNK1G2 | 0.775571 | 4 | 0 | 4 |
| DGCR2 | SERPINF2 | 0.770972 | 3 | 0 | 3 |
| DGCR2 | EEF1D | 0.768869 | 4 | 0 | 4 |
| DGCR2 | CDC42SE2 | 0.760481 | 3 | 0 | 3 |
| DGCR2 | PLCG1 | 0.76043 | 3 | 0 | 3 |
| DGCR2 | DDX27 | 0.748764 | 3 | 0 | 3 |
| DGCR2 | ARHGEF11 | 0.746048 | 3 | 0 | 3 |
| DGCR2 | DCAF7 | 0.744395 | 3 | 0 | 3 |
| DGCR2 | ASXL1 | 0.740627 | 3 | 0 | 3 |
| DGCR2 | NCSTN | 0.729263 | 5 | 0 | 4 |
| DGCR2 | KDM4B | 0.72912 | 5 | 0 | 5 |
| DGCR2 | PLSCR1 | 0.728193 | 3 | 0 | 3 |
| DGCR2 | OCIAD2 | 0.728106 | 3 | 0 | 3 |
For details and further investigation, click here
