| Full name: chloride voltage-gated channel 7 | Alias Symbol: CLC-7|OPTA2|CLC7|ClC-7|PPP1R63 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 1186 | HGNC ID: HGNC:2025 | Ensembl Gene: ENSG00000103249 | OMIM ID: 602727 |
| Drug and gene relationship at DGIdb | |||
Expression of CLCN7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLCN7 | 1186 | 38069_at | 0.7329 | 0.0316 | |
| GSE20347 | CLCN7 | 1186 | 38069_at | 0.3906 | 0.0001 | |
| GSE23400 | CLCN7 | 1186 | 209235_at | 0.0620 | 0.0281 | |
| GSE26886 | CLCN7 | 1186 | 38069_at | 0.1759 | 0.1188 | |
| GSE29001 | CLCN7 | 1186 | 209235_at | 0.0282 | 0.8665 | |
| GSE38129 | CLCN7 | 1186 | 38069_at | 0.3124 | 0.0006 | |
| GSE45670 | CLCN7 | 1186 | 38069_at | 0.4294 | 0.0001 | |
| GSE63941 | CLCN7 | 1186 | 38069_at | -0.6114 | 0.0068 | |
| GSE77861 | CLCN7 | 1186 | 38069_at | 0.2596 | 0.0203 | |
| GSE97050 | CLCN7 | 1186 | A_23_P129334 | 0.2741 | 0.4966 | |
| SRP007169 | CLCN7 | 1186 | RNAseq | 1.5099 | 0.0034 | |
| SRP008496 | CLCN7 | 1186 | RNAseq | 1.0896 | 0.0043 | |
| SRP064894 | CLCN7 | 1186 | RNAseq | 0.9917 | 0.0000 | |
| SRP133303 | CLCN7 | 1186 | RNAseq | 0.8065 | 0.0000 | |
| SRP159526 | CLCN7 | 1186 | RNAseq | 0.4907 | 0.0018 | |
| SRP193095 | CLCN7 | 1186 | RNAseq | 0.8933 | 0.0000 | |
| SRP219564 | CLCN7 | 1186 | RNAseq | 0.9363 | 0.0248 | |
| TCGA | CLCN7 | 1186 | RNAseq | 0.0030 | 0.9472 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CLCN7 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CLCN7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLCN7 | 1186 | 5 | 5 | 20 | |
| GSE20123 | CLCN7 | 1186 | 5 | 4 | 21 | |
| GSE43470 | CLCN7 | 1186 | 4 | 7 | 32 | |
| GSE46452 | CLCN7 | 1186 | 38 | 1 | 20 | |
| GSE47630 | CLCN7 | 1186 | 13 | 6 | 21 | |
| GSE54993 | CLCN7 | 1186 | 3 | 5 | 62 | |
| GSE54994 | CLCN7 | 1186 | 5 | 9 | 39 | |
| GSE60625 | CLCN7 | 1186 | 4 | 0 | 7 | |
| GSE74703 | CLCN7 | 1186 | 4 | 5 | 27 | |
| GSE74704 | CLCN7 | 1186 | 3 | 2 | 15 | |
| TCGA | CLCN7 | 1186 | 19 | 14 | 63 |
Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.
Somatic mutations of CLCN7:
Generating mutation plots.
Highly correlated genes for CLCN7:
Showing top 20/820 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLCN7 | PSMG3 | 0.773987 | 4 | 0 | 4 |
| CLCN7 | TSEN15 | 0.77369 | 3 | 0 | 3 |
| CLCN7 | PPP1R37 | 0.772247 | 3 | 0 | 3 |
| CLCN7 | RIOK1 | 0.772167 | 4 | 0 | 3 |
| CLCN7 | QSOX2 | 0.771804 | 4 | 0 | 4 |
| CLCN7 | RPL7L1 | 0.769988 | 3 | 0 | 3 |
| CLCN7 | TCL1B | 0.769813 | 3 | 0 | 3 |
| CLCN7 | USP42 | 0.768606 | 3 | 0 | 3 |
| CLCN7 | ALG1 | 0.764377 | 4 | 0 | 4 |
| CLCN7 | SMCR8 | 0.762829 | 3 | 0 | 3 |
| CLCN7 | IL18BP | 0.750975 | 3 | 0 | 3 |
| CLCN7 | LRRC58 | 0.748023 | 4 | 0 | 4 |
| CLCN7 | CLPTM1L | 0.744479 | 4 | 0 | 4 |
| CLCN7 | DDX55 | 0.743442 | 4 | 0 | 4 |
| CLCN7 | CHML | 0.743011 | 3 | 0 | 3 |
| CLCN7 | DNAJB11 | 0.742562 | 4 | 0 | 4 |
| CLCN7 | UTP23 | 0.741747 | 3 | 0 | 3 |
| CLCN7 | BCL9 | 0.737484 | 3 | 0 | 3 |
| CLCN7 | MRPL47 | 0.733816 | 4 | 0 | 4 |
| CLCN7 | RCBTB1 | 0.733785 | 3 | 0 | 3 |
For details and further investigation, click here
