| Full name: actin filament associated protein 1 like 1 | Alias Symbol: FLJ36748 | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 134265 | HGNC ID: HGNC:26714 | Ensembl Gene: ENSG00000157510 | OMIM ID: 614410 |
| Drug and gene relationship at DGIdb | |||
Expression of AFAP1L1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AFAP1L1 | 134265 | 226955_at | 0.6522 | 0.6125 | |
| GSE26886 | AFAP1L1 | 134265 | 1555542_at | -0.0441 | 0.7721 | |
| GSE45670 | AFAP1L1 | 134265 | 226955_at | 0.7336 | 0.0556 | |
| GSE53622 | AFAP1L1 | 134265 | 39871 | 0.7701 | 0.0000 | |
| GSE53624 | AFAP1L1 | 134265 | 39871 | 1.0233 | 0.0000 | |
| GSE63941 | AFAP1L1 | 134265 | 226955_at | 0.3863 | 0.6609 | |
| GSE77861 | AFAP1L1 | 134265 | 1555542_at | -0.0613 | 0.6139 | |
| GSE97050 | AFAP1L1 | 134265 | A_32_P167239 | 0.3948 | 0.2839 | |
| SRP007169 | AFAP1L1 | 134265 | RNAseq | 1.0830 | 0.0778 | |
| SRP008496 | AFAP1L1 | 134265 | RNAseq | 1.2571 | 0.0175 | |
| SRP064894 | AFAP1L1 | 134265 | RNAseq | 1.1414 | 0.0000 | |
| SRP133303 | AFAP1L1 | 134265 | RNAseq | 0.7675 | 0.0275 | |
| SRP159526 | AFAP1L1 | 134265 | RNAseq | 0.3506 | 0.2718 | |
| SRP193095 | AFAP1L1 | 134265 | RNAseq | 1.2300 | 0.0000 | |
| SRP219564 | AFAP1L1 | 134265 | RNAseq | 1.1126 | 0.0589 | |
| TCGA | AFAP1L1 | 134265 | RNAseq | 0.2265 | 0.0631 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by AFAP1L1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AFAP1L1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AFAP1L1 | 134265 | 1 | 12 | 17 | |
| GSE20123 | AFAP1L1 | 134265 | 1 | 12 | 17 | |
| GSE43470 | AFAP1L1 | 134265 | 2 | 10 | 31 | |
| GSE46452 | AFAP1L1 | 134265 | 0 | 27 | 32 | |
| GSE47630 | AFAP1L1 | 134265 | 0 | 20 | 20 | |
| GSE54993 | AFAP1L1 | 134265 | 9 | 1 | 60 | |
| GSE54994 | AFAP1L1 | 134265 | 2 | 15 | 36 | |
| GSE60625 | AFAP1L1 | 134265 | 0 | 0 | 11 | |
| GSE74703 | AFAP1L1 | 134265 | 2 | 7 | 27 | |
| GSE74704 | AFAP1L1 | 134265 | 1 | 7 | 12 | |
| TCGA | AFAP1L1 | 134265 | 7 | 37 | 52 |
Total number of gains: 25; Total number of losses: 148; Total Number of normals: 315.
Somatic mutations of AFAP1L1:
Generating mutation plots.
Highly correlated genes for AFAP1L1:
Showing top 20/428 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AFAP1L1 | THSD1 | 0.743284 | 3 | 0 | 3 |
| AFAP1L1 | LRRC8C | 0.719279 | 3 | 0 | 3 |
| AFAP1L1 | VAPA | 0.707385 | 3 | 0 | 3 |
| AFAP1L1 | C6orf141 | 0.698533 | 4 | 0 | 3 |
| AFAP1L1 | IKBIP | 0.697058 | 5 | 0 | 5 |
| AFAP1L1 | MYO5A | 0.691902 | 5 | 0 | 5 |
| AFAP1L1 | STK17A | 0.681648 | 3 | 0 | 3 |
| AFAP1L1 | ACP1 | 0.681488 | 3 | 0 | 3 |
| AFAP1L1 | MB21D2 | 0.674622 | 5 | 0 | 5 |
| AFAP1L1 | USP14 | 0.670571 | 3 | 0 | 3 |
| AFAP1L1 | STAMBP | 0.669474 | 3 | 0 | 3 |
| AFAP1L1 | DCBLD1 | 0.668097 | 5 | 0 | 5 |
| AFAP1L1 | RAB32 | 0.667038 | 5 | 0 | 5 |
| AFAP1L1 | SLC39A1 | 0.664494 | 3 | 0 | 3 |
| AFAP1L1 | SGPP1 | 0.661121 | 5 | 0 | 4 |
| AFAP1L1 | PRSS23 | 0.658697 | 5 | 0 | 5 |
| AFAP1L1 | SEC23A | 0.656479 | 5 | 0 | 5 |
| AFAP1L1 | RAB31 | 0.65509 | 6 | 0 | 6 |
| AFAP1L1 | TMEM19 | 0.65493 | 3 | 0 | 3 |
| AFAP1L1 | PPP1R18 | 0.652021 | 4 | 0 | 3 |
For details and further investigation, click here
