| Full name: sphingosine-1-phosphate phosphatase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q23.2 | ||
| Entrez ID: 81537 | HGNC ID: HGNC:17720 | Ensembl Gene: ENSG00000126821 | OMIM ID: 612826 |
| Drug and gene relationship at DGIdb | |||
Expression of SGPP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SGPP1 | 81537 | 223391_at | 0.2334 | 0.7954 | |
| GSE20347 | SGPP1 | 81537 | 221268_s_at | 0.2584 | 0.0727 | |
| GSE23400 | SGPP1 | 81537 | 221268_s_at | 0.3588 | 0.0000 | |
| GSE26886 | SGPP1 | 81537 | 223391_at | -0.1628 | 0.6932 | |
| GSE29001 | SGPP1 | 81537 | 221268_s_at | 0.0264 | 0.8298 | |
| GSE38129 | SGPP1 | 81537 | 221268_s_at | 0.3691 | 0.0369 | |
| GSE45670 | SGPP1 | 81537 | 223391_at | 0.0310 | 0.9500 | |
| GSE53622 | SGPP1 | 81537 | 5538 | 0.5383 | 0.0000 | |
| GSE53624 | SGPP1 | 81537 | 5538 | 0.2524 | 0.0609 | |
| GSE63941 | SGPP1 | 81537 | 223391_at | -0.4625 | 0.4867 | |
| GSE77861 | SGPP1 | 81537 | 223391_at | -0.0297 | 0.9656 | |
| GSE97050 | SGPP1 | 81537 | A_23_P347048 | 0.4142 | 0.2151 | |
| SRP007169 | SGPP1 | 81537 | RNAseq | 0.2798 | 0.4730 | |
| SRP008496 | SGPP1 | 81537 | RNAseq | 0.6213 | 0.0464 | |
| SRP064894 | SGPP1 | 81537 | RNAseq | 0.5182 | 0.0384 | |
| SRP133303 | SGPP1 | 81537 | RNAseq | 0.7340 | 0.0012 | |
| SRP159526 | SGPP1 | 81537 | RNAseq | 0.1034 | 0.7637 | |
| SRP193095 | SGPP1 | 81537 | RNAseq | 0.5150 | 0.0101 | |
| SRP219564 | SGPP1 | 81537 | RNAseq | 0.8792 | 0.0358 | |
| TCGA | SGPP1 | 81537 | RNAseq | -0.0316 | 0.7402 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SGPP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SGPP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SGPP1 | 81537 | 7 | 3 | 20 | |
| GSE20123 | SGPP1 | 81537 | 7 | 3 | 20 | |
| GSE43470 | SGPP1 | 81537 | 8 | 2 | 33 | |
| GSE46452 | SGPP1 | 81537 | 16 | 3 | 40 | |
| GSE47630 | SGPP1 | 81537 | 11 | 9 | 20 | |
| GSE54993 | SGPP1 | 81537 | 3 | 9 | 58 | |
| GSE54994 | SGPP1 | 81537 | 18 | 5 | 30 | |
| GSE60625 | SGPP1 | 81537 | 0 | 2 | 9 | |
| GSE74703 | SGPP1 | 81537 | 7 | 2 | 27 | |
| GSE74704 | SGPP1 | 81537 | 3 | 2 | 15 | |
| TCGA | SGPP1 | 81537 | 32 | 15 | 49 |
Total number of gains: 112; Total number of losses: 55; Total Number of normals: 321.
Somatic mutations of SGPP1:
Generating mutation plots.
Highly correlated genes for SGPP1:
Showing top 20/424 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SGPP1 | BDP1 | 0.779665 | 3 | 0 | 3 |
| SGPP1 | GINS4 | 0.743977 | 3 | 0 | 3 |
| SGPP1 | TMEM51 | 0.735007 | 3 | 0 | 3 |
| SGPP1 | SRFBP1 | 0.73369 | 4 | 0 | 4 |
| SGPP1 | GPC1 | 0.719814 | 3 | 0 | 3 |
| SGPP1 | ILKAP | 0.713153 | 3 | 0 | 3 |
| SGPP1 | CD163L1 | 0.707141 | 3 | 0 | 3 |
| SGPP1 | SRA1 | 0.705348 | 4 | 0 | 4 |
| SGPP1 | FLNB | 0.697768 | 4 | 0 | 3 |
| SGPP1 | USP40 | 0.696945 | 3 | 0 | 3 |
| SGPP1 | LRRC8C | 0.689817 | 3 | 0 | 3 |
| SGPP1 | MB21D2 | 0.682653 | 5 | 0 | 4 |
| SGPP1 | ZC3H13 | 0.681117 | 3 | 0 | 3 |
| SGPP1 | ZBTB25 | 0.680022 | 4 | 0 | 4 |
| SGPP1 | SOX7 | 0.679435 | 3 | 0 | 3 |
| SGPP1 | GEMIN5 | 0.679427 | 3 | 0 | 3 |
| SGPP1 | RAP2C | 0.679344 | 4 | 0 | 3 |
| SGPP1 | MTX3 | 0.678973 | 4 | 0 | 3 |
| SGPP1 | ZFYVE16 | 0.677553 | 4 | 0 | 3 |
| SGPP1 | DYNC1LI2 | 0.67481 | 3 | 0 | 3 |
For details and further investigation, click here
