| Full name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | Alias Symbol: KIAA1099|GGAP1 | ||
| Type: protein-coding gene | Cytoband: 2q37.2 | ||
| Entrez ID: 116987 | HGNC ID: HGNC:16922 | Ensembl Gene: ENSG00000157985 | OMIM ID: 608651 |
| Drug and gene relationship at DGIdb | |||
Expression of AGAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGAP1 | 116987 | 204066_s_at | -0.5632 | 0.4709 | |
| GSE20347 | AGAP1 | 116987 | 204066_s_at | 0.1572 | 0.4571 | |
| GSE23400 | AGAP1 | 116987 | 204066_s_at | 0.1029 | 0.0877 | |
| GSE26886 | AGAP1 | 116987 | 204066_s_at | 0.0811 | 0.8168 | |
| GSE29001 | AGAP1 | 116987 | 204066_s_at | 0.1716 | 0.6887 | |
| GSE38129 | AGAP1 | 116987 | 204066_s_at | -0.0776 | 0.7725 | |
| GSE45670 | AGAP1 | 116987 | 228240_at | -0.3394 | 0.0614 | |
| GSE53622 | AGAP1 | 116987 | 107785 | -0.0577 | 0.5067 | |
| GSE53624 | AGAP1 | 116987 | 107785 | 0.1250 | 0.1311 | |
| GSE63941 | AGAP1 | 116987 | 204066_s_at | -0.6584 | 0.1572 | |
| GSE77861 | AGAP1 | 116987 | 204066_s_at | 0.4140 | 0.0882 | |
| GSE97050 | AGAP1 | 116987 | A_33_P3317305 | -0.2247 | 0.5676 | |
| SRP007169 | AGAP1 | 116987 | RNAseq | 1.7342 | 0.0009 | |
| SRP008496 | AGAP1 | 116987 | RNAseq | 1.1803 | 0.0046 | |
| SRP064894 | AGAP1 | 116987 | RNAseq | -0.2329 | 0.1621 | |
| SRP133303 | AGAP1 | 116987 | RNAseq | 0.0473 | 0.7978 | |
| SRP159526 | AGAP1 | 116987 | RNAseq | 0.4455 | 0.1744 | |
| SRP193095 | AGAP1 | 116987 | RNAseq | 0.4106 | 0.0065 | |
| SRP219564 | AGAP1 | 116987 | RNAseq | -0.1528 | 0.7819 | |
| TCGA | AGAP1 | 116987 | RNAseq | -0.2827 | 0.0002 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by AGAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AGAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGAP1 | 116987 | 1 | 11 | 18 | |
| GSE20123 | AGAP1 | 116987 | 1 | 11 | 18 | |
| GSE43470 | AGAP1 | 116987 | 1 | 9 | 33 | |
| GSE46452 | AGAP1 | 116987 | 0 | 5 | 54 | |
| GSE47630 | AGAP1 | 116987 | 4 | 5 | 31 | |
| GSE54993 | AGAP1 | 116987 | 3 | 2 | 65 | |
| GSE54994 | AGAP1 | 116987 | 7 | 11 | 35 | |
| GSE60625 | AGAP1 | 116987 | 0 | 3 | 8 | |
| GSE74703 | AGAP1 | 116987 | 1 | 7 | 28 | |
| GSE74704 | AGAP1 | 116987 | 1 | 5 | 14 | |
| TCGA | AGAP1 | 116987 | 11 | 32 | 53 |
Total number of gains: 30; Total number of losses: 101; Total Number of normals: 357.
Somatic mutations of AGAP1:
Generating mutation plots.
Highly correlated genes for AGAP1:
Showing top 20/424 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGAP1 | FAM76B | 0.824881 | 3 | 0 | 3 |
| AGAP1 | CRKL | 0.745164 | 3 | 0 | 3 |
| AGAP1 | USP37 | 0.743533 | 3 | 0 | 3 |
| AGAP1 | MSI2 | 0.726069 | 3 | 0 | 3 |
| AGAP1 | TMEM205 | 0.722515 | 4 | 0 | 3 |
| AGAP1 | ERI3 | 0.720801 | 3 | 0 | 3 |
| AGAP1 | APH1B | 0.719754 | 3 | 0 | 3 |
| AGAP1 | CYTH3 | 0.706634 | 3 | 0 | 3 |
| AGAP1 | PPIE | 0.705564 | 5 | 0 | 5 |
| AGAP1 | C1QTNF7 | 0.704366 | 3 | 0 | 3 |
| AGAP1 | KHDRBS1 | 0.700444 | 4 | 0 | 3 |
| AGAP1 | ZXDA | 0.697757 | 4 | 0 | 4 |
| AGAP1 | MEAF6 | 0.693244 | 4 | 0 | 3 |
| AGAP1 | EFCAB7 | 0.691129 | 4 | 0 | 3 |
| AGAP1 | THOC2 | 0.690906 | 3 | 0 | 3 |
| AGAP1 | MAML1 | 0.688516 | 3 | 0 | 3 |
| AGAP1 | GABRA3 | 0.687098 | 3 | 0 | 3 |
| AGAP1 | PDE8A | 0.687093 | 3 | 0 | 3 |
| AGAP1 | ZNF740 | 0.686987 | 3 | 0 | 3 |
| AGAP1 | POLR3GL | 0.683432 | 3 | 0 | 3 |
For details and further investigation, click here
