CRKL

 

Full name: CRK like proto-oncogene, adaptor protein Alias Symbol: 
Type: protein-coding gene Cytoband: 22q11.21
Entrez ID: 1399 HGNC ID: HGNC:2363 Ensembl Gene: ENSG00000099942 OMIM ID: 602007
Drug and gene relationship at DGIdb
Screen Evidence:

 

CRKL involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04015Rap1 signaling pathway
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa04666Fc gamma R-mediated phagocytosis
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05220Chronic myeloid leukemia

 

Expression of CRKL:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CRKL 1399 212180_at 0.6850 0.0856
GSE20347 CRKL 1399 212180_at 0.2330 0.1707
GSE23400 CRKL 1399 212180_at 0.5282 0.0000
GSE26886 CRKL 1399 212180_at -0.2558 0.0988
GSE29001 CRKL 1399 212180_at 0.2860 0.1918
GSE38129 CRKL 1399 212180_at 0.5258 0.0008
GSE45670 CRKL 1399 212180_at 0.6260 0.0148
GSE53622 CRKL 1399 164068 0.4944 0.0000
GSE53624 CRKL 1399 92033 0.5028 0.0000
GSE63941 CRKL 1399 212180_at 0.3096 0.5173
GSE77861 CRKL 1399 212180_at 0.8917 0.0027
GSE97050 CRKL 1399 A_24_P935009 0.1377 0.5662
SRP007169 CRKL 1399 RNAseq 0.3523 0.2266
SRP008496 CRKL 1399 RNAseq 0.6446 0.0142
SRP064894 CRKL 1399 RNAseq 0.4459 0.0476
SRP133303 CRKL 1399 RNAseq 0.3888 0.0291
SRP159526 CRKL 1399 RNAseq 0.2374 0.3221
SRP193095 CRKL 1399 RNAseq 0.3562 0.0084
SRP219564 CRKL 1399 RNAseq 0.5050 0.1949
TCGA CRKL 1399 RNAseq 0.1913 0.0002

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CRKL expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CRKL:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CRKL 1399 6 7 17
GSE20123 CRKL 1399 6 7 17
GSE43470 CRKL 1399 4 7 32
GSE46452 CRKL 1399 33 1 25
GSE47630 CRKL 1399 8 5 27
GSE54993 CRKL 1399 3 6 61
GSE54994 CRKL 1399 11 7 35
GSE60625 CRKL 1399 5 0 6
GSE74703 CRKL 1399 4 5 27
GSE74704 CRKL 1399 3 4 13
TCGA CRKL 1399 27 17 52

Total number of gains: 110; Total number of losses: 66; Total Number of normals: 312.  

 

Somatic mutations of CRKL:

 

Generating mutation plots.

 

Highly correlated genes for CRKL:

 

Showing top 20/1109 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CRKLCOMMD20.782219404
CRKLTHAP50.767802303
CRKLKHNYN0.766885303
CRKLZHX20.765059303
CRKLFAM32A0.76485404
CRKLALKBH60.761019303
CRKLSENP10.760429303
CRKLZCCHC30.758845303
CRKLGATAD10.755808303
CRKLDNAJC190.750772303
CRKLAGAP10.745164303
CRKLRNF1150.736299303
CRKLRNF400.73574303
CRKLLRRC410.734936303
CRKLHPS30.731605403
CRKLPRDM150.731452303
CRKLRCBTB10.729891303
CRKLKLHL50.729294403
CRKLTMEM1170.727822303
CRKLLRRC580.725884404

For details and further investigation, click here